Search Results - "Vajdy, M."

Microparticles for intranasal immunization by Vajdy, Michael, O’Hagan, Derek T.

“…Of the several routes available for mucosal immunization, the nasal route is particularly attractive because of ease of administration and the induction of…”
Get full text

Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate by Srivastava, Indresh K, Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, Martin, Loic, Vita, Claudio, Zhu, Ping, Roux, Kenneth H, Vojtech, Lucia, C Montefiori, David, Donnelly, John, Ulmer, Jeffrey B, Barnett, Susan W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Generation and maintenance of mucosal memory B cell responses? by Vajdy, M

“…The mucosal immune system comprises B cells that can mount potent antibody responses against a variety of mucosal pathogens. Mucosal B cell responses can play…”
Get more information

Role of Immunoglobulin A in Protection against Reovirus Entry into Murine Peyer's Patches by Silvey, K J, Hutchings, A B, Vajdy, M, Petzke, M M, Neutra, M R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Impaired mucosal immune responses in interleukin 4-targeted mice by Vajdy, M, Kosco-Vilbois, M H, Kopf, M, Köhler, G, Lycke, N

“…Interleukin 4-targeted (IL-4-/-) mice are defective in T helper (Th)2 cytokine production as determined after nematode infection. As Th2 cells appear to be…”
Get full text

Genetically detoxified mutants of heat‐labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T‐cell responses against HIV‐1 gag‐p55 by Neidleman, J. A., Vajdy, M., Ugozzoli, M., Ott, G., O'hagan, D.

“…Summary There is an urgent need for prophylactic and therapeutic vaccines against human immunodeficiency virus (HIV). Mucosal immunization strategies have…”
Get full text

Long-term Protection in Hamsters against Human Parainfluenza Virus Type 3 Following Mucosal or Combinations of Mucosal and Systemic Immunizations with Chimeric Alphavirus-based Replicon Particles by Greer, C.E, Zhou, F, Goodsell, A, Legg, H.S, Tang, Z, zur Megede, J, Uematsu, Y, Polo, J.M, Vajdy, M

“…No licensed vaccines are available to protect against parainfluenza virus type 3 (PIV3), a significant health risk for infants. In search of a safe vaccine, we…”
Get full text

Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant by VAJDY, M, LYCKE, N

“…In the present study we investigated immunological memory at the cellular level following oral immunization using cholera toxin (CT) as the mucosal adjuvant…”
Get full text

Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization by VAJDY, M, LYCKE, N. Y

“…This study was conducted to investigate whether cholera toxin (CT), used as a mucosal adjuvant, would promote the development in mice of immunological memory…”
Get full text

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance by KJERRULF, M., GRDIC, D., EKMAN, L., SCHÖN, K., VAJDY, M., LYCKE, N. Y.

“…Interferon‐γ (IFN‐γ) receptor knock‐out (IFN‐γR−/−) mice were used to analyse the role of IFN‐γ in mucosal immune responses following oral immunization. We…”
Get full text

Mucosal memory B cells retain the ability to produce IgM antibodies 2 years after oral immunization by Vajdy, M, Lycke, N

“…In recent studies we have demonstrated that immunological B- and T-cell memory may be stimulated effectively by oral immunization, simply by admixing protein…”
Get full text

Induction of optimal immune responses against human immunodeficiency virus at mucosal portals of entry by Vajdy, M

“…Mucosal surfaces comprise the largest surface area of the human body and are the first line of defense against many pathogens. In fact, over 90% of common…”
Get more information

Presence of antigen-specific long-term memory cells in systemic lymphoid tissues as well as locally in the gut lamina propria following oral immunization with cholera toxin adjuvant by Vajdy, M, Lycke, N

Get more information

Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope by Barnett, Susan W, Srivastava, Indresh K, Kan, Elaine, Zhou, Fengmin, Goodsell, Amanda, Cristillo, Anthony D, Ferrai, Maria Grazia, Weiss, Deborah E, Letvin, Norman L, Montefiori, David, Pal, Ranajit, Vajdy, Michael

“…Worldwide, the majority of human immunodeficiency virus (HIV) infections occur by heterosexual transmission. Thus, the development of a vaccine that can…”
Get full text

Mucosal adjuvants and delivery systems for protein-, DNA- and RNA-based vaccines by Vajdy, Michael, Srivastava, Indresh, Polo, John, Donnelly, John, O'Hagan, Derek, Singh, Manmohan

“…Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination offers several benefits over parenteral routes of vaccination,…”
Get full text

An Alphavirus Replicon Particle Chimera Derived from Venezuelan Equine Encephalitis and Sindbis Viruses Is a Potent Gene-Based Vaccine Delivery Vector by Perri, Silvia, Greer, Catherine E, Thudium, Kent, Doe, Barbara, Legg, Harold, Liu, Hong, Romero, Raul E, Tang, Zequn, Bin, Qian, Dubensky, Jr, Thomas W, Vajdy, Michael, Otten, Gillis R, Polo, John M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity by Singh, Manmohan, Vajdy, Michael, Gardner, Jason, Briones, Maylene, O’Hagan, Derek

“…There is an urgent need to develop vaccines against transmission of HIV through the vaginal and rectal mucosa. In the present study we tested the ability of…”
Get full text

A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza by Vajdy, Michael, Baudner, Barbara, Del Giudice, Giuseppe, O’Hagan, Derek

“…Abstract Influenza infections are a major cause of mortality and morbidity worldwide. Therefore, there is a need to establish vaccines and immunization…”
Get full text

Effects of a Th1- versus a Th2-biased immune response in protection against Helicobacter pylori challenge in mice by Taylor, Jennifer M., Ziman, Melanie E., Canfield, Don R., Vajdy, Michael, Solnick, Jay V.

“…The roles that T helper type 1 (Th1) and T helper type 2 (Th2) Helicobacter pylori-specific immune responses play in protection from H. pylori challenge are…”
Get full text

Human Immunodeficiency Virus Type 1 Gag–Specific Vaginal Immunity and Protection after Local Immunizations with Sindbis Virus–Based Replicon Particles by Vajdy, Michael, Gardner, Jason, Neidleman, Jason, Cuadra, Lina, Greer, Catherine, Perri, Silvia, O’Hagan, Derek, Polo, John M.

“…The majority of human immunodeficiency virus (HIV) infections occur through vaginal and rectal transmission. In seeking a safe, nonreplicating gene-delivery…”
Get full text