Search Results - "Vajdi, Amir"

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer by Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A

“…Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been…”
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Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1 by Chen, Hsiao-Yun, Durmaz, Yavuz T., Li, Yixiang, Sabet, Amin H., Vajdi, Amir, Denize, Thomas, Walton, Emily, Laimon, Yasmin Nabil, Doench, John G., Mahadevan, Navin R., Losman, Julie-Aurore, Barbie, David A., Tolstorukov, Michael Y., Rudin, Charles M., Sen, Triparna, Signoretti, Sabina, Oser, Matthew G.

“…Some small cell lung cancers (SCLCs) are highly sensitive to inhibitors of the histone demethylase LSD1. LSD1 inhibitors are thought to induce their…”
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Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment by Szabo, Peter M., Vajdi, Amir, Kumar, Namit, Tolstorukov, Michael Y., Chen, Benjamin J., Edwards, Robin, Ligon, Keith L., Chasalow, Scott D., Chow, Kin-Hoe, Shetty, Aniket, Bolisetty, Mohan, Holloway, James L., Golhar, Ryan, Kidd, Brian A., Hull, Philip Ansumana, Houser, Jeff, Vlach, Logan, Siemers, Nathan O., Saha, Saurabh

“…Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these…”
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The Extracellular Milieu of Toxoplasma's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming by Primo, Vincent A, Rezvani, Yasaman, Farrell, Andrew, Murphy, Connor Q, Lou, Jingjing, Vajdi, Amir, Marth, Gabor T, Zarringhalam, Kourosh, Gubbels, Marc-Jan

“…Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for over 1,500 generations with the goal of mapping host-independent in vitro…”
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The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells by Noyes, Christopher, Kitajima, Shunsuke, Li, Fengkai, Suita, Yusuke, Miriyala, Saradha, Isaac, Shakson, Ahsan, Nagib, Knelson, Erik, Vajdi, Amir, Tani, Tetsuo, Thai, Tran C., Xu, Derek, Murai, Junko, Tapinos, Nikos, Takahashi, Chiaki, Barbie, David A., Yajima, Mamiko

“…Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that…”
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Patch-DCA: improved protein interface prediction by utilizing structural information and clustering DCA scores by Vajdi, Amir, Zarringhalam, Kourosh, Haspel, Nurit

“…Abstract Motivation Over the past decade, there have been impressive advances in determining the 3D structures of protein complexes. However, there are still…”
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway by Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

“…Eradicating tumor dormancy that develops following epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small…”
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Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity by Mahadevan, Navin R, Knelson, Erik H, Wolff, Jacquelyn O, Vajdi, Amir, Saigí, Maria, Campisi, Marco, Hong, Deli, Thai, Tran C, Piel, Brandon, Han, Saemi, Reinhold, Bruce B, Duke-Cohan, Jonathan S, Poitras, Michael J, Taus, Luke J, Lizotte, Patrick H, Portell, Andrew, Quadros, Victor, Santucci, Alison D, Murayama, Takahiko, Cañadas, Israel, Kitajima, Shunsuke, Akitsu, Aoi, Fridrikh, Maya, Watanabe, Hideo, Reardon, Brendan, Gokhale, Prafulla C, Paweletz, Cloud P, Awad, Mark M, Van Allen, Eliezer M, Lako, Ana, Wang, Xi-Tao, Chen, Benjamin, Hong, Fangxin, Sholl, Lynette M, Tolstorukov, Michael Y, Pfaff, Kathleen, Jänne, Pasi A, Gjini, Evisa, Edwards, Robin, Rodig, Scott, Reinherz, Ellis L, Oser, Matthew G, Barbie, David A

“…Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity,…”
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Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Chemotherapy in Advanced Urothelial Carcinoma by Fléchon, Aude, Morales-Barrera, Rafael, Powles, Thomas, Alva, Ajjai, Özgüroğlu, Mustafa, Csöszi, Tibor, Loriot, Yohann, Rodriguez-Vida, Alejo, Géczi, Lajos, Cheng, Susanna Y, Fradet, Yves, Oudard, Stéphane, Vulsteke, Christof, Gunduz, Seyda, Mamtani, Ronac, Yu, Evan Y, Montesa Pino, Alvaro, Anido, Urbano, Sendur, Mehmet A N, Gravis, Gwenaelle, Révész, János, Kostorov, Vladimir, Huillard, Olivier, Ma, Junshui, Rajasagi, Mohini, Vajdi, Amir, Lunceford, Jared, Cristescu, Razvan, Imai, Kentaro, Homet Moreno, Blanca, Matsubara, Nobuaki

“…The three-arm, phase III KEYNOTE-361 study did not meet its dual primary endpoints of progression-free survival (PFS) or overall survival (OS) with first-line…”
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Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade by Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V, Lizotte, Patrick H, Mahadevan, Navin R, Greene, Jonathan R, Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J, Thai, Tran C, Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J, Kirschmeier, Paul T, Liu, David, Giannakis, Marios, Jenkins, Russell W, Gokhale, Prafulla C, Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D, Hammerman, Peter S, Miret, Juan J, Paweletz, Cloud P, Barbie, David A

“…Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar…”
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Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer by Hong, Deli, Knelson, Erik H, Li, Yixiang, Durmaz, Yavuz T, Gao, Wenhua, Walton, Emily, Vajdi, Amir, Thai, Tran, Sticco-Ivins, Maura, Sabet, Amin H, Jones, Kristen L, Schinzel, Anna C, Bronson, Rod T, Nguyen, Quang-De, Tolstorukov, Michael Y, Vivero, Marina, Signoretti, Sabina, Barbie, David A, Oser, Matthew G

“…Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of…”
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Abstract 1012: Determinants of immune evasion in MET driven lung cancer by Saigi, Maria, Yoshida, Ryohei, Knelson, Erik H, Mahadevan, Navin R, Vajdi, Amir, Cañadas, Israel, Thai, Tran C, Awad, Mark M., Sánchez-Céspedes, Montse, Barbie, David A

“…Abstract PURPOSE: The 5' ectonucleotidase (NT5E) encodes for the CD73 membrane protein that converts the extracellular AMP into adenosine (Ado), an…”
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Exploratory biomarker analysis of the phase 3 KEYNOTE-604 study of pembrolizumab plus etoposide for extensive-stage SCLC by Rudin, Charles M., Kim, Hye Ryun, Navarro, Alejandro, Gottfried, Maya, Peters, Solange, Csoszi, Tibor, Cheema, Parneet Kaur, Rodriguez-Abreu, Delvys, Wollner, Mira, Yang, James Chih-Hsin, Mazieres, Julien, Kato, Terufumi, Kalemkerian, Gregory Peter, Dettman, Elisha, Edmondson, Mackenzie, Vajdi, Amir, Loboda, Andrey, El-Osta, Hazem Edmond, Zhao, Bin, Awad, Mark M.

“…8503 Background: In the phase 3 KEYNOTE-604 study of extensive-stage small-cell lung cancer (ES-SCLC; NCT03066778), first-line pembrolizumab (pembro) plus…”
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Association of TMB and PD-L1 with efficacy of first-line pembrolizumab (pembro) or pembro + chemotherapy (chemo) versus chemo in patients (pts) with advanced urothelial carcinoma (UC) from KEYNOTE-361 by Morales-Barrera, Rafael, Powles, Thomas, Ozguroglu, Mustafa, Csoszi, Tibor, Loriot, Yohann, Flechon, Aude, Matsubara, Nobuaki, Rodriguez-Vida, Alejo, Geczi, Lajos, Cheng, Susanna Y., Fradet, Yves, Oudard, Stephane, Gunduz, Seyda, Ma, Junshui, Rajasagi, Mohini, Vajdi, Amir, Cristescu, Razvan, Imai, Kentaro, Homet Moreno, Blanca, Alva, Ajjai Shivaram

“…Abstract only 540 Background: The 3-arm, open-label, phase 3 KEYNOTE-361 study (NCT02853305) evaluated first-line pembro ± chemo vs chemo in advanced UC…”
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Association between biomarkers and clinical outcomes of lenvatinib + pembrolizumab in advanced renal cell carcinoma (RCC): Results from Study 111/KEYNOTE-146 by Lee, Chung-Han, Rasco, Drew W., Rao, Arpit, Taylor, Matthew H., Hsieh, James J, Pinto, Alvaro, Vogelzang, Nicholas J., Cao, Z. Alexander, Suttner, Leah, Loboda, Andrey, Vajdi, Amir, Predoiu, Raluca Andreia, Nebozhyn, Michael, Lunceford, Jared, Perini, Rodolfo F., Matsui, Junji, Minoshima, Yukinori, Dutcus, Corina E., Dutta, Lea, Motzer, Robert J.

“…Abstract only 375 Background: In the Study 111/KEYNOTE-146 trial (NCT02501096; N=147), lenvatinib (lenva) + pembrolizumab (pembro) showed encouraging antitumor…”
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The Extracellular Milieu of Toxoplasma 's Lytic Cycle Drives Lab Adaptation, Primarily by Transcriptional Reprogramming by Primo, Jr, Vincent A, Rezvani, Yasaman, Farrell, Andrew, Murphy, Connor Q, Lou, Jingjing, Vajdi, Amir, Marth, Gabor T, Zarringhalam, Kourosh, Gubbels, Marc-Jan

“…Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for over 1,500 generations with the goal of mapping host-independent virulence…”
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Effect of STK11 mutations on efficacy of PD-1 inhibition in non-small cell lung cancer (NSCLC) and dependence on KRAS mutation status by Ricciuti, Biagio, Arbour, Kathryn Cecilia, Lin, Jessica Jiyeong, Vokes, Natalie, Vajdi Hoojghan, Amir, Li, Yvonne Y., Cherniack, Andrew D., Recondo, Gonzalo, Lamberti, Giuseppe, Venkatraman, Deepti, Rizvi, Hira, Egger, Jacklynn V., Plodkowski, Andrew J., Khosrowjerdi, Sara, Digumarthy, Subba R, Nishino, Mizuki, Sholl, Lynette M., Gainor, Justin F., Hellmann, Matthew David, Awad, Mark M.

“…Abstract only e15113 Background: STK11 mutations ( STK11m) have been associated with resistance to ICI in KRAS-mutant ( KRASm) NSCLC. Whether STK11m status…”
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Detecting chromosomal structural variation using jaccard distance and parallel architecture by Mohebbi, Hamidreza, Vajdi, Amir, Haspel, Nurit, Simovici, Dan

“…Understanding the nature of many diseases, including cancer, requires locating somatically acquired rearrangements corresponding to large-scale chromosomal…”
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A new DP algorithm for comparing gene expression data using geometric similarity by Vajdi, Amir, Haspel, Nurit, Banaee, Hadi

“…Microarray gene expression data comes as a time series, where the expression level of a gene is recorded at specific time points. Comparing the time series…”
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A new DP algorithm for comparing gene expression data using geometric similarity by Vajdi, Amir, Haspel, Nurit, Banaee, Hadi

“…Microarray gene expression data comes as a time series, where the expression level of a gene is recorded at specific time points. Comparing the time series…”
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