Search Results - "Vaitheesvaran, Bhavapriya"

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors by Haeusler, Rebecca A., Hartil, Kirsten, Vaitheesvaran, Bhavapriya, Arrieta-Cruz, Isabel, Knight, Colette M., Cook, Joshua R., Kammoun, Helene L., Febbraio, Mark A., Gutierrez-Juarez, Roger, Kurland, Irwin J., Accili, Domenico

“…Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former…”
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SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase by Laurent, Gaëlle, German, Natalie J., Saha, Asish K., de Boer, Vincent C.J., Davies, Michael, Koves, Timothy R., Dephoure, Noah, Fischer, Frank, Boanca, Gina, Vaitheesvaran, Bhavapriya, Lovitch, Scott B., Sharpe, Arlene H., Kurland, Irwin J., Steegborn, Clemens, Gygi, Steven P., Muoio, Deborah M., Ruderman, Neil B., Haigis, Marcia C.

“…Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich conditions increase lipogenesis, whereas nutrient deprivation…”
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Loss of the RNA polymerase III repressor MAF1 confers obesity resistance by Bonhoure, Nicolas, Byrnes, Ashlee, Moir, Robyn D, Hodroj, Wassim, Preitner, Frédéric, Praz, Viviane, Marcelin, Genevieve, Chua, Jr, Streamson C, Martinez-Lopez, Nuria, Singh, Rajat, Moullan, Norman, Auwerx, Johan, Willemin, Gilles, Shah, Hardik, Hartil, Kirsten, Vaitheesvaran, Bhavapriya, Kurland, Irwin, Hernandez, Nouria, Willis, Ian M

“…MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient…”
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Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury by Ó Broin, Pilib, PhD, Vaitheesvaran, Bhavapriya, PhD, Saha, Subhrajit, PhD, Hartil, Kirsten, PhD, Chen, Emily I., PhD, Goldman, Devorah, PhD, Fleming, William Harv, MD, PhD, Kurland, Irwin J., MD, PhD, Guha, Chandan, MBBS, PhD, Golden, Aaron, PhD

“…Purpose Assessing whole-body radiation injury and absorbed dose is essential for remediation efforts following accidental or deliberate exposure in medical,…”
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Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1 by Zhao, Xiaoping, Feng, Daorong, Wang, Qun, Abdulla, Arian, Xie, Xiao-Jun, Zhou, Jie, Sun, Yan, Yang, Ellen S, Liu, Lu-Ping, Vaitheesvaran, Bhavapriya, Bridges, Lauren, Kurland, Irwin J, Strich, Randy, Ni, Jian-Quan, Wang, Chenguang, Ericsson, Johan, Pessin, Jeffrey E, Ji, Jun-Yuan, Yang, Fajun

“…Altered lipid metabolism underlies several major human diseases, including obesity and type 2 diabetes. However, lipid metabolism pathophysiology remains…”
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NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism by Tontonoz, Peter, Pei, Liming, Waki, Hironori, Vaitheesvaran, Bhavapriya, Wilpitz, Damien C, Kurland, Irwin J

“…Hepatic glucose production is crucial for glucose homeostasis, and its dysregulation contributes to the pathogenesis of diabetes. Here, we show that members of…”
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The Fasted/Fed Mouse Metabolic Acetylome: N6-Acetylation Differences Suggest Acetylation Coordinates Organ-Specific Fuel Switching by Yang, Li, Vaitheesvaran, Bhavapriya, Hartil, Kirsten, Robinson, Alan J, Hoopmann, Michael R, Eng, Jimmy K, Kurland, Irwin J, Bruce, James E

“…The elucidation of extra-nuclear lysine acetylation has been of growing interest, as the cosubstrate for acetylation, acetyl CoA, is at a key metabolic…”
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Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins[S] by Miao, Ji, Haas, Joel T., Manthena, Praveen, Wang, Yanning, Zhao, Enpeng, Vaitheesvaran, Bhavapriya, Kurland, Irwin J., Biddinger, Sudha B.

“…The liver plays a central role in metabolism and mediating insulin action. To dissect the effects of insulin on the liver in vivo, we have studied liver…”
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Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice by HAIHONG ZONG, WANG, Cheng-Chun, VAITHEESVARAN, Bhavapriya, KURLAND, Irwin J, WANJIN HONG, PESSIN, Jeffrey E

“…Previous studies have demonstrated that the VAMP8 protein plays a complex role in the control of granule secretion, transport vesicle trafficking,…”
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Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation by Vaitheesvaran, Bhavapriya, Yang, Li, Hartil, Kirsten, Glaser, Sherrye, Yazulla, Stephen, Bruce, James E, Kurland, Irwin J

“…FAAH (fatty acid amide hydrolase), primarily expressed in the liver, hydrolyzes the endocannabinoids fatty acid ethanolamides (FAA). Human FAAH gene mutations…”
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Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice by Yang, Yingjuan, Tarabra, Elena, Yang, Gong-She, Vaitheesvaran, Bhavapriya, Palacios, Gustavo, Kurland, Irwin J, Pessin, Jeffrey E, Bastie, Claire C

“…Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also…”
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Amelogenin Interacts with Cytokeratin-5 in Ameloblasts during Enamel Growth by Ravindranath, Rajeswari M.H., Basilrose, Rajam M., Ravindranath, Naren H., Vaitheesvaran, Bhavapriya

“…The enamel protein amelogenin binds to GlcNAc (Ravindranath, R. M. H., Moradian-Oldak, R., and Fincham, A.G. (1999) J. Biol. Chem. 274, 2464–2471) and to the…”
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SIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA decarboxylase by Laurent, Gaëlle, German, Natalie J, Saha, Asish K, de Boer, Vincent CJ, Fischer, Frank, Boanca, Gina, Dephoure, Noah, Vaitheesvaran, Bhavapriya, Davies, Michael, Gygi, Steven P, Muoio, Deborah M, Kurland, Irwin J, Steegborn, Clemens, Ruderman, Neil B, Haigis, Marcia C

“…Doc number: P30…”
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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α by Zhong, Lei, D'Urso, Agustina, Toiber, Debra, Sebastian, Carlos, Henry, Ryan E., Vadysirisack, Douangsone D., Guimaraes, Alexander, Marinelli, Brett, Wikstrom, Jakob D., Nir, Tomer, Clish, Clary B., Vaitheesvaran, Bhavapriya, Iliopoulos, Othon, Kurland, Irwin, Dor, Yuval, Weissleder, Ralph, Shirihai, Orian S., Ellisen, Leif W., Espinosa, Joaquin M., Mostoslavsky, Raul

“…SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span…”
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The Critical Role of MAF1 in Repression of RNA Polymerase III Impacts Metabolic Efficiency in Mice by Willis, Ian M, Bonhoure, Nicolas, Moir, Robyn D, Byrnes, Ashlee, Hodroj, Wassim, Praz, Viviane, Preitner, Frederic, Marcelin, Genevieve, Chua, Streamson, Martinez‐Lopez, Nuria, Singh, Rajat, Auwerx, Johan, Willemin, Gilles, Shah, Hardik, Hartil, Kirsten, Vaitheesvaran, Bhavapriya, Kurland, Irwin, Hernandez, Nouria

“…Abstract only MAF1 functions to promote metabolic economy by repressing RNA polymerase (pol) III transcription of highly abundant cellular RNAs, most notably…”
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Advantages of dynamic “closed loop” stable isotope flux phenotyping over static “open loop” clamps in detecting silent genetic and dietary phenotypes by Vaitheesvaran, Bhavapriya, Chueh, Fu-Yu, Xu, Jun, Trujillo, Chuck, Saad, M. F, Lee, W. N. P, McGuinness, Owen P, Kurland, Irwin J

“…In vivo insulin sensitivity can be assessed using “open loop” clamp or “closed loop” methods. Open loop clamp methods are static, and fix plasma glucose…”
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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1a by Zhong, Lei, D'Urso, Agustina, Toiber, Debra, Sebastian, Carlos, Henry, Ryan E, Vadysirisack, Douangsone D, Guimaraes, Alexander, Marinelli, Brett, Wikstrom, Jakob D, Nir, Tomer, Clish, Clary B, Vaitheesvaran, Bhavapriya, Iliopoulos, Othon, Kurland, Irwin, Dor, Yuval, Weissleder, Ralph, Shirihai, Orian S, Ellisen, Leif W, Espinosa, Joaquin M, Mostoslavsky, Raul

“…SIRT6 is a member of a highly conserved family of NAD super(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span…”
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Integrated Control Of Hepatic Lipogenesis Vs. Glucose Production Requires FoxO Transcription Factors by Haeusler, Rebecca A., Hartil, Kirsten, Vaitheesvaran, Bhavapriya, Arrieta–Cruz, Isabel, Knight, Colette M., Cook, Joshua R., Kammoun, Helene L., Febbraio, Mark A., Gutierrez–Juarez, Roger, Kurland, Irwin J., Accili, Domenico

“…Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former…”
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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha by Zhong, Lei, D'Urso, Agustina, Toiber, Debra, Sebastian, Carlos, Henry, Ryan E, Vadysirisack, Douangsone D, Guimaraes, Alexander, Marinelli, Brett, Wikstrom, Jakob D, Nir, Tomer, Clish, Clary B, Vaitheesvaran, Bhavapriya, Iliopoulos, Othon, Kurland, Irwin, Dor, Yuval, Weissleder, Ralph, Shirihai, Orian S, Ellisen, Leif W, Espinosa, Joaquin M, Mostoslavsky, Raul

“…SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span…”
Get full text