Search Results - "Vaillancourt, Valerie"

Discovery and development of veterinary antiparasitic drugs: past, present and future by Woods, Debra J, Vaillancourt, Valerie A, Wendt, John A, Meeus, Patrick F

“…Despite investment in programs to manage the development of resistance to existing agents, this continues to drive the need for discovery of novel…”
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2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases by Schnute, Mark E., Anderson, David J., Brideau, Roger J., Ciske, Fred L., Collier, Sarah A., Cudahy, Michele M., Eggen, MariJean, Genin, Michael J., Hopkins, Todd A., Judge, Thomas M., Kim, Euibong J., Knechtel, Mary L., Nair, Sajiv K., Nieman, James A., Oien, Nancee L., Scott, Allen, Tanis, Steven P., Vaillancourt, Valerie A., Wathen, Michael W., Wieber, Janet L.

“…A potent series of broad-spectrum antivirals against human herpesviruses has been identified which inhibit HCMV, HSV-1, EBV, and VZV polymerases. A novel…”
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Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses by Brideau, Roger J., Knechtel, Mary L., Huang, Audris, Vaillancourt, Valerie A., Vera, Ellen E., Oien, Nancee L., Hopkins, Todd A., Wieber, Janet L., Wilkinson, Karen F., Rush, Bob D., Schwende, Francis J., Wathen, Michael W.

“…We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly…”
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Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid:  Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent by Larsen, Scott D, Connell, Mark A, Cudahy, Michele M, Evans, Bruce R, May, Paul D, Meglasson, Martin D, O'Sullivan, Theresa J, Schostarez, Heinrich J, Sih, John C, Stevens, F. Craig, Tanis, Steven P, Tegley, Christopher M, Tucker, John A, Vaillancourt, Valerie A, Vidmar, Thomas J, Watt, William, Yu, Jen H

“…3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin sensitivity and to promote weight loss selectively from adipose tissue…”
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Inhibition of clinical isolates of human cytomegalovirus and varicella zoster virus by PNU-183792, a 4-oxo-dihydroquinoline by Knechtel, Mary L., Huang, Audris, Vaillancourt, Valerie A., Brideau, Roger J.

“…The susceptibility of human cytomegalovirus (CMV) and varicella zoster virus (VZV) clinical isolates to PNU‐183792, a 4‐oxo‐dihydroquinoline, was examined. The…”
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Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid by Vaillancourt, Valerie A, Larsen, Scott D, Tanis, Steven P, Burr, Jeffery E, Connell, Mark A, Cudahy, Michele M, Evans, Bruce R, Fisher, Peter V, May, Paul D, Meglasson, Martin D, Robinson, Deborah D, Stevens, F. Craig, Tucker, John A, Vidmar, Thomas J, Yu, Jen H

“…3-Guanidinopropionic acid (1) has been demonstrated both to improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal…”
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Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase by Vaillancourt, Valerie A, Cudahy, Michele M, Staley, Sandra A, Brideau, Roger J, Conrad, Steven J, Knechtel, Mary L, Oien, Nancee L, Wieber, Janet L, Yagi, Yoshihiko, Wathen, Michael W

“…ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and…”
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Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs by Curtis, Michael P., Vaillancourt, Valerie, Goodwin, Richard M., Chubb, Nathan A.L., Howson, William, McTier, Tom L., Pullins, Aleah, Zinser, Erich W., Meeus, Patrick F.M., Woods, Debra J., Hedges, Laura, Stuk, Tim, Price, Jeffrey E., Koch, Jason D., Menon, Sanjay R.

“…[Display omitted] Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for…”
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Synthesis and absolute configuration of the antiparasitic furanosesquiterpenes (-)-furodysin and (-)-furodysinin. Camphor as a six-membered ring chiral pool template by Vaillancourt, Valerie, Agharahimi, Mohamad R, Sundram, Uma N, Richou, Olivier, Faulkner, D. John, Albizati, Kim F

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Synthesis and absolute configuration of (-)-furodysinin. New transformations of camphor derivatives by Richou, Olivier, Vaillancourt, Valerie, Faulkner, D. John, Albizati, Kim F

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Synthesis and absolute configuration of (+)-hapalindole Q by Vaillancourt, Valerie, Albizati, Kim F

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A one-step method for the .alpha.-arylation of camphor. Synthesis of (-)-cannabidiol and (-)-cannabidiol dimethyl ether by Vaillancourt, Valerie, Albizati, Kim F

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New uses of camphor in synthesis: Camphor as a six-membered ring chiral pool substrate by Vaillancourt, Valerie Ann

“…Through fragmentation of the C1-C7 bond, camphor has been shown to be a versatile six-membered ring chiral pool substrate. This methodology was demonstrated by…”
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