Search Results - "Vail, David"
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1
Prospects for a Rim County Renaissance: Pandemic as Economic Opportunity
Published in Maine policy review (30-12-2021)Get full text
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Veterinary Cooperative Oncology Group—Common Terminology Criteria for Adverse Events (VCOG‐CTCAE v2) following investigational therapy in dogs and cats
Published in Veterinary & comparative oncology (01-06-2021)“…The updated VCOG‐CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 and published within…”
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Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting
Published in PloS one (12-08-2021)“…Murine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary tumor in situ vaccination combined with targeted…”
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Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
Published in Science translational medicine (14-07-2021)“…Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help prime and propagate antitumor immunity. We hypothesized that delivering…”
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5
Computed Tomography Imaging of Solid Tumors Using a Liposomal-Iodine Contrast Agent in Companion Dogs with Naturally Occurring Cancer
Published in PloS one (31-03-2016)“…Companion dogs with naturally occurring cancer serve as an important large animal model in translational research because they share strong similarities with…”
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Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL)
Published in PloS one (04-09-2013)“…We present the first comparison of global transcriptional changes in canine and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the…”
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A comparison of 12‐ and 19‐week CHOP protocols using non‐randomized, contemporaneous controls
Published in Veterinary & comparative oncology (01-09-2019)“…This study is a concurrent comparison of two versions of CHOP protocols, a 19‐week CHOP and a comparatively overall dose‐intense 12‐week CHOP. The 12‐week…”
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Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial
Published in Veterinary & comparative oncology (01-09-2024)“…ABSTRACT MAPK has been reported as a key oncogenic pathway for canine histiocytic sarcoma, which can be pharmacologically targeted with trametinib, a small…”
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Invited Essay: Field Notes: Exploring the STEM-Humanities History of Nebraska's Agriculture: Expanded Remarks for the 2018 Warner Lecture
Published in Great Plains research (01-09-2019)Get full text
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Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology
Published in Science translational medicine (03-02-2016)Get more information
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Development of a next-generation sequencing protocol for the canine T cell receptor beta chain repertoire
Published in Veterinary immunology and immunopathology (01-02-2024)“…Profiling the T cell receptor (TCR) repertoire using next-generation sequencing has become common in both human and translational research. Companion dogs with…”
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Short survival time following palliative‐intent hypofractionated radiotherapy for non‐resectable canine thyroid carcinoma: A retrospective analysis of 20 dogs
Published in Veterinary radiology & ultrasound (01-01-2019)“…Radiotherapy is the treatment of choice for non‐resectable canine thyroid carcinoma. High tumor response rates and median survival times of 2 years or longer…”
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Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs
Published in PloS one (08-06-2010)“…Signaling through the mTOR pathway contributes to growth, progression and chemoresistance of several cancers. Accordingly, inhibitors have been developed as…”
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Advanced Cancer Imaging Applied in the Comparative Setting
Published in Frontiers in oncology (07-02-2020)“…The potential for companion (pet) species with spontaneously arising tumors to act as surrogates for preclinical development of advanced cancer imaging…”
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Farming across Borders: A Transnational History of the North American West ed. by Sterling Evans (review)
Published in Great plains quarterly (2019)Get full text
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Farming by Rail: Demonstration Trains and the Rise of Mobile Agricultural Science in the Great Plains
Published in Great plains quarterly (01-04-2018)“…In the early 1900s, railroad companies throughout the Great Plains worked with agricultural extension personnel and land-grant colleges to design demonstration…”
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Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients
Published in Clinical cancer research (15-09-2009)“…On June 20, 2008, a meeting entitled “Translation of new cancer treatments from canine to human cancer patients,” sponsored by the National Cancer Institute in…”
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Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
Published in Journal of veterinary internal medicine (01-03-2021)“…Background Most dogs with sinonasal tumors (SNT) treated with radiation therapy (RT) died because of local disease progression. Hypothesis/Objectives Our…”
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Administration of intratumoral GD2-directed interleukin-2 immunocytokine and local radiation therapy to activate immune rejection of spontaneous canine melanoma
Published in Melanoma research (01-08-2024)“…Canine malignant melanoma provides a clinically relevant, large animal parallel patient population to study the GD2-reactive hu14.18-IL-2 immunocytokine as it…”
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Concurrent use of rabacfosadine and L‐asparaginase for relapsed or refractory multicentric lymphoma in dogs
Published in Journal of veterinary internal medicine (01-03-2020)“…Background Rabacfosadine (RAB), a novel antineoplastic agent conditionally licensed for the treatment of lymphoma in dogs, is efficacious in both naïve and…”
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