Search Results - "Vaidya, Anup"
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Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation
Published in Journal of virology (15-10-2019)“…Epstein-Barr virus (EBV) maintains a life-long infection due to the ability to alternate between latent and lytic modes of replication. Lytic reactivation…”
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2
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation
Published in Frontiers in immunology (15-11-2019)“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
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3
Nucleosome conformation dictates the histone code
Published in eLife (06-02-2024)“…Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized 'codes' that…”
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Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
Published in Epigenetics & chromatin (24-01-2020)“…Plant homeodomain (PHD) fingers are central "readers" of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by…”
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
Published in eLife (19-05-2023)“…In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to…”
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Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch
Published in Nucleic acids research (09-09-2024)“…Abstract Monoubiquitination of histones H2B-K120 (H2BK120ub) and H2A-K119 (H2AK119ub) play opposing roles in regulating transcription and chromatin compaction…”
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A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer
Published in Genes & development (01-12-2021)“…Mutations in the chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in expression are linked to cancer…”
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Methylomic correlates of autophagy activity in cystic fibrosis
Published in Journal of cystic fibrosis (01-07-2019)“…Autophagy is a highly regulated, biological process that provides energy during periods of stress and starvation. This conserved process also acts as a defense…”
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3090 – KDM4A/C SUSTAIN AN ONCOGENIC PROGRAM BY EPIGENETIC REWIRING OF ONCOGENIC AND LINEAGE ENHANCERS
Published in Experimental hematology (01-08-2020)“…Many prior studies have focused on the role of mutations in epigenetic factors in cancer (e.g., EZH2, CREBBP, EP300, KMT2C, KMT2D) but drugs targeting these…”
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Abstract 7027: Direct multi-omics for the masses: Linking DNA methylation to chromatin targets via TEM-seq
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract DNA methylation (DNAme) is an epigenetic mark that includes the modification of cytosine resides (5mC) within CpG islands. In addition to well…”
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Abstract 7026: Multi-omic genomic mapping with long read sequencing
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Gene transcription is regulated by the complex interplay between histone post-translational modifications (PTMs), chromatin associated proteins…”
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Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Published in Science advances (09-08-2023)“…Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex…”
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Elucidating the role of ARKL1 in regulating Epstein-Barr virus (EBV) iinfection
Published 01-01-2016“…ARKL1 and Arkadia were previously identified as proteins that bind to the CK2β KSSR motif. Since the Epstein-Barr virus (EBV) protein Epstein-Barr nuclear…”
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Dissertation -
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Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015: Yogyakarta, Indonesia. 4-6 June 2015
Published in BMC proceedings (13-04-2016)“…A1 Hope and despair in the current treatment of nasopharyngeal cancer IB Tan I1 NPC international incidence and risk factors Ellen T Chang I2 Familial…”
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