Search Results - "Vahedi, Shahrooz"

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency by Vahedi, Shahrooz, Chufan, Eduardo E., Ambudkar, Suresh V.

“…[Display omitted] P-glycoprotein (P-gp), an ATP-dependent efflux pump, is linked to the development of multidrug resistance in cancer cells. However, the…”
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Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1) by Sajid, Andaleeb, Raju, Natarajan, Lusvarghi, Sabrina, Vahedi, Shahrooz, Swenson, Rolf E, Ambudkar, Suresh V

“…Fluorescent conjugates of drugs can be used to study cellular functions and pharmacology. These compounds interact with proteins as substrates or inhibitors,…”
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Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses by Iqbal, Jawed, Ansari, Mairaj Ahmed, Kumar, Binod, Dutta, Dipanjan, Roy, Arunava, Chikoti, Leela, Pisano, Gina, Dutta, Sujoy, Vahedi, Shahrooz, Veettil, Mohanan Valiya, Chandran, Bala

“…IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune…”
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Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein by Vahedi, Shahrooz, Lusvarghi, Sabrina, Pluchino, Kristen, Shafrir, Yinon, Durell, Stewart R., Gottesman, Michael M., Ambudkar, Suresh V.

“…P-glycoprotein (P-gp), an ATP-dependent efflux pump, is associated with the development of multidrug resistance in cancer cells. Antibody-mediated blockade of…”
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Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter by Robey, Robert W., Robinson, Andrea N., Ali-Rahmani, Fatima, Huff, Lyn M., Lusvarghi, Sabrina, Vahedi, Shahrooz, Hotz, Jordan M., Warner, Andrew C., Butcher, Donna, Matta, Jennifer, Edmondson, Elijah F., Lee, Tobie D., Roth, Jacob S., Lee, Olivia W., Shen, Min, Tanner, Kandice, Hall, Matthew D., Ambudkar, Suresh V., Gottesman, Michael M.

“…Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1 ) and ABCG2 (encoded by ABCG2…”
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Human ATP-binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines by Wu, Chung-Pu, Hsieh, Ya-Ju, Murakami, Megumi, Vahedi, Shahrooz, Hsiao, Sung-Han, Yeh, Ni, Chou, An-Wei, Li, Yan-Qing, Wu, Yu-Shan, Yu, Jau-Song, Ambudkar, Suresh V.

“…[Display omitted] Ricolinostat is the first orally available, selective inhibitor of histone deacetylase 6 (HDAC6), currently under evaluation in clinical…”
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Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons by Vahedi, Shahrooz, Rajabian, Mehrnoosh, Misaghian, Arman, Grbec, Daniel, Simon, Horst H, Alavian, Kambiz N

“…Parkinson's disease is the second most common neurodegenerative disorder. The pathological hallmark of the disease is degeneration of midbrain dopaminergic…”
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Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease by Baker-Nigh, Alaina, Vahedi, Shahrooz, Davis, Elena Goetz, Weintraub, Sandra, Bigio, Eileen H, Klein, William L, Geula, Changiz

“…The mechanisms that contribute to selective vulnerability of the magnocellular basal forebrain cholinergic neurons in neurodegenerative diseases, such as…”
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Abstract 5217: Mechanism of polyspecificity of P-glycoprotein: Substitution of fifteen residues in the drug-binding pocket with tyrosine reveals a negative correlation between substrate size and transport by Vahedi, Shahrooz, Chufan, Eduardo, Ambudkar, Suresh V.

“…Abstract P-glycoprotein (P-gp) belongs to the superfamily of ATP-binding cassette (ABC) transporters. This energy-dependent cell surface transporter can pump…”
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Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1) by Murakami, Megumi, Sajid, Andaleeb, Lusvarghi, Sabrina, Durell, Stewart R., Abel, Biebele, Vahedi, Shahrooz, Golin, John, Ambudkar, Suresh V.

“…Human P-glycoprotein (P-gp) or ABCB1 is overexpressed in many cancers and has been implicated in altering the bioavailability of chemotherapeutic drugs due to…”
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Synthesis and characterization of BODIPY‐FL‐cyclosporine A as a substrate for both human and mouse multidrug resistance‐linked P‐glycoprotein by Sajid, Andaleeb, Natarajan, Raju, Lusvarghi, Sabrina, Vahedi, Shahrooz, Swenson, Rolf, Ambudkar, Suresh V

“…Generation of fluorescent conjugates of small molecules and existing drugs has facilitated their use in addressing cellular functions and pharmacological…”
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Asymmetric TDP pathology in primary progressive aphasia with right hemisphere language dominance by Kim, Garam, Vahedi, Shahrooz, Gefen, Tamar, Weintraub, Sandra, Bigio, Eileen H, Mesulam, Marek-Marsel, Geula, Changiz

“…OBJECTIVETo quantitatively examine the regional densities and hemispheric distribution of the 43-kDa transactive response DNA-binding protein (TDP-43)…”
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Abstract 4895: Human ATP-binding cassette proteins ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines by Hsiao, Sung-Han, Vahedi, Shahrooz, Ambudkar, Suresh V., Wu, Chung-Pu

“…Abstract Histone deacetylase 6 (HDAC6), localized primarily in the cytoplasm, is responsible for the deacetylation of non-histone substrates such as α-tubulin…”
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Abstract 3041: Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation by Vahedi, Shahrooz, Chueh, Fu-Yu, Yu, Chao-Lan

“…Abstract The purpose of our study is to determine whether and how lymphocyte-specific protein tyrosine kinase (Lck) may exhibit novel functions in cancer cell…”
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Lymphocyte-specific protein tyrosine kinase in mitochondria to repress oxidative phosphorylation by Vahedi, Shahrooz, Chueh, Fu-Yu, Chandran, Bala, Yu, Chao-Lan

“…Many cancer cells exhibit reduced mitochondrial respiration as part of metabolic reprogramming to support tumor growth. Mitochondrial localization of several…”
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Evidence for the Interaction of A 3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1) by Abel, Biebele, Tosh, Dilip K, Durell, Stewart R, Murakami, Megumi, Vahedi, Shahrooz, Jacobson, Kenneth A, Ambudkar, Suresh V

“…P-glycoprotein (P-gp) is a multidrug transporter that is expressed on the luminal surface of epithelial cells in the kidney, intestine, bile-canalicular…”
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Abstract 2702: Therapeutic potentials of STAT5 inhibitors in overcoming bortezomib resistance in human T-cell leukemia by Chueh, Fu-Yu, Vahedi, Shahrooz, Chueh, Fu-Shin, Yu, Chao-Lan

“…Abstract The purpose of our study is to define the mechanism of bortezomib resistance in cancer therapy and to identify novel approaches in overcoming the…”
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Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation by Vahedi, Shahrooz, Chueh, Fu-Yu, Chandran, Bala, Yu, Chao-Lan

“…Many cancer cells exhibit reduced mitochondrial respiration as part of metabolic reprogramming to support tumor growth. Mitochondrial localization of several…”
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Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-[beta] Responses by Iqbal, Jawed, Ansari, Mairaj Ahmed, Kumar, Binod, Dutta, Dipanjan, Roy, Arunava, Chikoti, Leela, Pisano, Gina, Dutta, Sujoy, Vahedi, Shahrooz, Veettil, Mohanan Valiya, Chandran, Bala

“…IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune…”
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Non-canonical Lck signaling in leukemic T-cell lines by Vahedi, Shahrooz

“…Protein tyrosine kinases (PTK) are large families of enzymes which have been implicated in a variety of biological processes. PTKs are traditionally known as…”
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