Search Results - "Vagne, Constance"
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MITF -High and MITF -Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma
Published in Clinical cancer research (15-11-2017)“…Understanding tumor heterogeneity is an important challenge in current cancer research. Transcription and epigenetic profiling of cultured melanoma cells have…”
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Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells
Published in Molecular metabolism (Germany) (01-09-2021)“…GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation…”
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Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
Published in Molecular metabolism (Germany) (01-11-2019)“…Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy…”
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High-dimensional single-cell analysis of human natural killer cell heterogeneity
Published in Nature immunology (01-08-2024)“…Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged…”
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Reciprocal sign epistasis and truncation selection: When is recombination favorable in a pre-breeding program with a selfing species?
Published in Journal of theoretical biology (07-12-2015)“…Since the dawn of agriculture, humans have applied artificial selection on traits of interest, regardless of their genetic architecture. Yet, still today, most…”
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Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant
Published in Cell reports. Medicine (18-10-2022)“…Harnessing innate immunity is emerging as a promising therapeutic approach in cancer. We report here the design of tetraspecific molecules engaging natural…”
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MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra and inter-tumoral heterogeneity of primary melanoma
Published in Clinical cancer research (2017)“…PURPOSE: Understanding tumour heterogeneity is an important challenge in current cancer research. Transcription and epigenetic profiling of cultured melanoma…”
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Journal Article