Search Results - "Vaeaenaenen, H K"

Bone turnover markers and prediction of fracture: A prospective follow‐up study of 1040 elderly women for a mean of 9 years by Ivaska, Kaisa K, Gerdhem, Paul, Väänänen, H Kalervo, Åkesson, Kristina, Obrant, Karl J

“…Osteoporosis is characterized by compromised bone mass and strength, predisposing to an increased risk of fracture. Increased bone metabolism has been…”
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Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption by Michael, Husheem, Härkönen, Pirkko L, Väänänen, H Kalervo, Hentunen, Teuvo A

“…Using human peripheral blood CD14+ osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological…”
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Biochemical Markers of Bone Metabolism and Prediction of Fracture in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Alatalo, Sari L, Halleen, Jussi M, Hellman, Jukka, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Åkesson, Kristina, Obrant, Karl J

“…We studied the ability of various markers of bone turnover to predict fracture in 1040 randomly recruited 75‐year‐old women. A total of 178 of the women…”
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Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts by Heino, Terhi J, Hentunen, Teuvo A, Väänänen, H.Kalervo

“…Osteocytes are the most abundant cells in bone and there is increasing evidence that they control bone remodeling via direct cell-to-cell contacts and by…”
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Release of Intact and Fragmented Osteocalcin Molecules from Bone Matrix during Bone Resorption in Vitro by Ivaska, Kaisa K, Hentunen, Teuvo A, Vääräniemi, Jukka, Ylipahkala, Hannele, Pettersson, Kim, Väänänen, H Kalervo

“…Osteocalcin detected from serum samples is considered a specific marker of osteoblast activity and bone formation rate. However, osteocalcin embedded in bone…”
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Bone Marrow Cell Differentiation Induced by Mechanically Damaged Osteocytes in 3D Gel‐Embedded Culture by Kurata, Kosaku, Heino, Terhi J, Higaki, Hidehiko, Väänänen, H Kalervo

“…Osteocytes are suggested to have a crucial role in the initial resorptive phase of bone turnover after microdamage. To study the role of osteocytes in targeted…”
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Tartrate‐Resistant Acid Phosphatase 5b: A Novel Serum Marker of Bone Resorption by Halleen, Jussi M., Alatalo, Sari L., Suominen, Harri, Cheng, Sulin, Janckila, Anthony J., Väänänen, H. Kalervo

“…Human serum contains two forms of tartrate‐resistant acid phosphatase (TRAP), 5a and 5b. Of these, 5a contains sialic acid and 5b does not. We show here that…”
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Associations Between Homocysteine, Bone Turnover, BMD, Mortality, and Fracture Risk in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Obrant, Karl J, Åkesson, Kristina

“…Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from the OPRA study, high homocysteine…”
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The Effect of Oral Glucose Tolerance Test on Serum Osteocalcin and Bone Turnover Markers in Young Adults by Paldánius, P. M., Ivaska, K. K., Hovi, P., Andersson, S., Väänänen, H. K., Kajantie, E., Mäkitie, O.

“…Osteocalcin (OC) is an osteoblast-derived protein implicated in the regulation of glucose tolerance and energy metabolism. This endocrine function has been…”
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Serum TRACP 5b Is a Useful Marker for Monitoring Alendronate Treatment: Comparison With Other Markers of Bone Turnover by Nenonen, Arja, Cheng, Sulin, Ivaska, Kaisa K, Alatalo, Sari L, Lehtimäki, Terho, Schmidt‐Gayk, Heinrich, Uusi‐Rasi, Kirsti, Heinonen, Ari, Kannus, Pekka, Sievänen, Harri, Vuori, Ilkka, Väänänen, H Kalervo, Halleen, Jussi M

“…We studied clinical performance of serum TRACP 5b and other bone turnover markers, including S‐CTX, U‐DPD, S‐PINP, S‐BALP, and S‐OC, for monitoring alendronate…”
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Intracellular Machinery for Matrix Degradation in Bone‐Resorbing Osteoclasts by Vääräniemi, Jukka, Halleen, Jussi M, Kaarlonen, Katja, Ylipahkala, Hannele, Alatalo, Sari L, Andersson, Göran, Kaija, Helena, Vihko, Pirkko, Väänänen, H Kalervo

“…In osteoclasts, TRACP co‐localized with cathepsin K in transcytotic vesicles and was activated by cathepsin K in vitro, suggesting that TRACP may degrade…”
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Effect of impact exercise on bone metabolism by Vainionpää, A, Korpelainen, R, Väänänen, H. K, Haapalahti, J, Jämsä, T, Leppäluoto, J

“…Summary Regular impact exercise in premenopausal women caused positive osteogenic effects associated to low basal serum parathormone (PTH) but had no effects…”
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Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro by Michael, H, Härkönen, P L, Kangas, L, Väänänen, H K, Hentunen, T A

“…Background and purpose: Several selective oestrogen receptor modulators (SERMs) with oestrogen agonist effects in bone cells and without increased risk of…”
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Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro by Mulari, M T K, Qu, Q, Härkönen, P L, Väänänen, H K

“…Bone remodeling involves old bone resorption by osteoclasts and new bone formation by osteoblasts. However, the precise cellular mechanisms underlying these…”
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Removal of Osteoclast Bone Resorption Products by Transcytosis by Salo, Jari, Lehenkari, Petri, Mulari, Mika, Metsikkö, Kalervo, Väänänen, H. Kalervo

“…Osteoclasts are multinucleated cells responsible for bone resorption. During the resorption cycle, osteoclasts undergo dramatic changes in their polarity, and…”
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Urinary osteocalcin and serum pro-C-type natriuretic peptide predict linear catch-up growth in infants by Kilpeläinen, Leena, Ivaska, Kaisa K, Kuiri-Hänninen, Tanja, Väänänen, H Kalervo, Rehfeld, Jens F, Goetze, Jens P, Sankilampi, Ulla, Dunkel, Leo

“…Preterm (PT) infants are at risk of growth failure despite advanced early care and nutrition. In addition to poor weight gain, slow postnatal linear growth…”
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Strong Prediction of Fractures Among Older Adults by the Ratio of Carboxylated to Total Serum Osteocalcin by Luukinen, H., Käkönen, S.‐M., Pettersson, K., Koski, K., Laippala, P., Lövgren, T., Kivelä, S.‐L., Väänänen, H. K.

“…We examined serum total osteocalcin (TOC), carboxylated osteocalcin (COC), and their ratio (COC/TOC) by one‐step two‐site immunofluorescent assays in 87% (n =…”
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Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis by Gu, G, Hentunen, T A, Nars, M, Härkönen, P L, Väänänen, H K

“…Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in…”
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Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase by Halleen, Jussi M., Räisänen, Seija, Salo, Jari J., Reddy, Sakamuri V., Roodman, G. David, Hentunen, Teuvo A., Lehenkari, Petri P., Kaija, Helena, Vihko, Pirkko, Väänänen, H. Kalervo

“…Tartrate-resistant acid phosphatase (TRAP) is highly expressed in bone-resorbing osteoclasts and activated macrophages. It has been suggested that a…”
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Carbonic anhydrase III protects cells from hydrogen peroxide‐induced apoptosis by Räisänen, Seija R., Lehenkari, Petri, Tasanen, Merja, Rahkila, Paavo, Härkönen, Pirkko L., Kalervo Väänänen, H.

“…ABSTRACT Carbonic anhydrase III (CA III; EC 4.2.1.1) is a cytoplasmic enzyme that exhibits a relatively low carbon dioxide hydratase activity. It is expressed…”
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