Search Results - "Vadukoot, Anish"

Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists by Tolentino, Kirsten T., Mashinson, Viktoriya, Vadukoot, Anish K., Hopkins, Corey R.

“…[Display omitted] The dopamine receptor 4 (D4R) is highly expressed in both motor, associative and limbic subdivisions of the cortico-basal ganglia network…”
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Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics by Aretz, Christopher D, Vadukoot, Anish K, Hopkins, Corey R

“…The renal outer medullary potassium (ROMK) channel is a member of the inwardly rectifying family of potassium (Kir, Kir1.1) channels. It is primarily expressed…”
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Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1 by Mashinson, Viktoriya, Webster, Thomas M., Vadukoot, Anish K., Tolentino, Kirsten T., Simeon, Princess, Fatima, Iram, Dhawan, Punita, Hopkins, Corey R.

“…[Display omitted] Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, despite advancements in diagnosis. The main reason for…”
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Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics: Miniperspective by Aretz, Christopher D, Vadukoot, Anish K, Hopkins, Corey R

“…The renal outer medullary potassium (ROMK) channel is a member of the inwardly rectifying family of potassium (Kir, Kir1.1) channels. It is primarily expressed…”
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Curcumin as a Potential Therapeutic Agent in Certain Cancer Types by Vadukoot, Anish K, Mottemmal, Shabna, Vekaria, Pratikkumar H

“…Cancer is a devastating disease condition and is the second most common etiology of death globally. After decades of research in the field of hematological…”
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Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors by Engers, Darren W., Bollinger, Sean R., Felts, Andrew S., Vadukoot, Anish K., Williams, Charles H., Blobaum, Anna L., Lindsley, Craig W., Hong, Charles C., Hopkins, Corey R.

“…[Display omitted] The activin-like kinases are a family of kinases that play important roles in a variety of disease states. Of this class of kinases, ALK2,…”
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Synthesis and SAR Studies of 1H‑Pyrrolo[2,3‑b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors by Vadukoot, Anish K, Sharma, Swagat, Aretz, Christopher D, Kumar, Sushil, Gautam, Nagsen, Alnouti, Yazen, Aldrich, Amy L, Heim, Cortney E, Kielian, Tammy, Hopkins, Corey R

“…Herein we report the synthesis, SAR, and biological evaluation of a series of 1H-pyrrolo­[2,3-b]­pyridine-2-carboxamide derivatives as selective and potent…”
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KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo by Burkovetskaya, Maria E, Liu, Qiaoling, Vadukoot, Anish K, Gautam, Nagsen, Alnouti, Yazen, Kumar, Sushil, Miczek, Klaus, Buch, Shilpa, Hopkins, Corey R, Guo, Minglei

“…Cocaine addiction remains a major public concern throughout the world especially in developed countries. In the last three decades, significant achievements…”
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Synthesis and Biological Characterization of a Series of 2‑Sulfonamidebenzamides as Allosteric Modulators of MrgX1 by Sharma, Swagat, Peng, Qi, Vadukoot, Anish K., Aretz, Christopher D., Jensen, Aaron A., Wallick, Alexander I., Dong, Xinzhong, Hopkins, Corey R.

“…The present study describes our continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides as allosteric modulators of…”
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Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia by Bell-Horwath, Tiffany R., Vadukoot, Anish K., Thowfeik, Fathima Shazna, Li, Guorui, Wunderlich, Mark, Mulloy, James C., Merino, Edward J.

“…This study explores the possible use of reactive oxygen-activated DNA modifying agents against acute myeloid leukemia (AML). A key amine on the lead agent was…”
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Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells by Vadukoot, Anish K., AbdulSalam, Safnas F., Wunderlich, Mark, Pullen, Eboni D., Landero-Figueroa, Julio, Mulloy, James C., Merino, Eddie J.

“…[Display omitted] Some cancers, like acute myeloid leukemia (AML), use reactive oxygen species to endogenously activate cell proliferation and angiogenic…”
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Discovery and Characterization of 1H‑Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators by Wieting, Joshua M, Vadukoot, Anish K, Sharma, Swagat, Abney, Kristopher K, Bridges, Thomas M, Daniels, J. Scott, Morrison, Ryan D, Wickman, Kevin, Weaver, C. David, Hopkins, Corey R

“…The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence…”
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Functional Characterization of Pneumocystis carinii Inositol Transporter 1 by Cushion, Melanie T, Collins, Margaret S, Sesterhenn, Thomas, Porollo, Aleksey, Vadukoot, Anish Kizhakkekkara, Merino, Edward J

“…Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised…”
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PROTACs: Opportunities and Challenges Ahead in the Field of Drug Discovery by Vadukoot, Anish Kizhakkekkara

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Inhibition of the SET/MLL Histone Methyltransferase Complex as a Novel Epigenetic Targeted Therapy in Mixed Lineage Leukemia by Widden, Hayley, Moukha‐Chafiq, Omar, Whitaker, Robert, Vadukoot, Anish, Augello‐Szafran, Corinne, Boohaker, Rebecca, Bostwick, Robert, Suto, Mark, Placzek, William

“…Aggressive acute leukemias in children, adolescents, and adults arise due to a chromosomal translocation and subsequent fusion that occurs at chromosome 11q23…”
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Synthesis and SAR Studies of 1 H -Pyrrolo[2,3- b ]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors by Vadukoot, Anish K., Sharma, Swagat, Aretz, Christopher D., Kumar, Sushil, Gautam, Nagsen, Alnouti, Yazen, Aldrich, Amy L., Heim, Cortney E., Kielian, Tammy, Hopkins, Corey R.

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Discovery and Characterization of 1 H -Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators by Wieting, Joshua M., Vadukoot, Anish K., Sharma, Swagat, Abney, Kristopher K., Bridges, Thomas M., Daniels, J. Scott, Morrison, Ryan D., Wickman, Kevin, Weaver, C. David, Hopkins, Corey R.

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Targeting the stress response to ROS: Design and development of novel and selective anti-cancer agents by Kizhakkekkara Vadukoot, Anish

“…Cancer is defined as abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize. Cancer can be initiated by…”
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