Search Results - "Vadnais, Charles"

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 by Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik

“…GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia…”
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Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes by Shooshtarizadeh, Peiman, Helness, Anne, Vadnais, Charles, Brouwer, Nelleke, Beauchemin, Hugues, Chen, Riyan, Bagci, Halil, Staal, Frank J. T., Coté, Jean-François, Möröy, Tarik

“…Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell…”
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Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes by Beauchemin, Hugues, Shooshtarizadeh, Peiman, Vadnais, Charles, Vassen, Lothar, Pastore, Yves D, Möröy, Tarik

“…Mutations in are associated with inherited bleeding disorders called -related thrombocytopenias. We show here that mice with a megakaryocyte-specific deletion…”
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Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination by Rashkovan, Marissa, Vadnais, Charles, Ross, Julie, Gigoux, Mathieu, Suh, Woong-Kyung, Gu, Wei, Kosan, Christian, Möröy, Tarik

“…To be effective, the adaptive immune response requires a large repertoire of antigen receptors, which are generated through V(D)J recombination in lymphoid…”
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RAS transformation requires CUX1-dependent repair of oxidative DNA damage by Ramdzan, Zubaidah M, Vadnais, Charles, Pal, Ranjana, Vandal, Guillaume, Cadieux, Chantal, Leduy, Lam, Davoudi, Sayeh, Hulea, Laura, Yao, Lu, Karnezis, Anthony N, Paquet, Marilène, Dankort, David, Nepveu, Alain

“…The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated…”
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CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage by Vadnais, Charles, Davoudi, Sayeh, Afshin, Mojdeh, Harada, Ryoko, Dudley, Rachel, Clermont, Pier-Luc, Drobetsky, Elliot, Nepveu, Alain

“…The p110 Cut homeobox 1 (CUX1) transcription factor regulates genes involved in DNA replication and chromosome segregation. Using a genome-wide-approach, we…”
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Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1 by Fraszczak, Jennifer, Helness, Anne, Chen, Riyan, Vadnais, Charles, Robert, François, Khandanpour, Cyrus, Möröy, Tarik

“…A regulatory circuit that controls myeloid versus B lymphoid cell fate in hematopoietic progenitors has been proposed, in which a network of the transcription…”
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Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells by Gaudreau, Marie-Claude, Grapton, Damien, Helness, Anne, Vadnais, Charles, Fraszczak, Jennifer, Shooshtarizadeh, Peiman, Wilhelm, Brian, Robert, François, Heyd, Florian, Möröy, Tarik

“…The proliferation and survival of hematopoietic stem cells (HSCs) has to be strictly coordinated to ensure the timely production of all blood cells. Here we…”
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Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress by Desilets, Antoine, McCarvill, William, Aubin, Francine, Bahig, Houda, Ballivy, Olivier, Charpentier, Danielle, Filion, Édith, Jamal, Rahima, Lambert, Louise, Nguyen-Tan, Phuc Felix, Vadnais, Charles, Weng, Xiaoduan, Soulières, Denis

“…: 5-FU-based chemoradiotherapy (CRT) could be associated with severe treatment-related toxicities in patients harboring at-risk polymorphisms. : The studied…”
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The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts by Ramdzan, Zubaidah M, Pal, Ranjana, Kaur, Simran, Leduy, Lam, Bérubé, Ginette, Davoudi, Sayeh, Vadnais, Charles, Nepveu, Alain

“…Despite having long telomeres, mouse embryo fibroblasts (MEFs) senesce more rapidly than human diploid fibroblasts because of the accumulation of oxidative DNA…”
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p110 CUX1 Homeodomain Protein Stimulates Cell Migration and Invasion in Part through a Regulatory Cascade Culminating in the Repression of E-cadherin and Occludin by Kedinger, Valerie, Sansregret, Laurent, Harada, Ryoko, Vadnais, Charles, Cadieux, Chantal, Fathers, Kelly, Park, Morag, Nepveu, Alain

“…In this study, we investigated the mechanism by which the CUX1 transcription factor can stimulate cell migration and invasion. The full-length p200 CUX1 had a…”
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Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML by Botezatu, Lacramioara, Michel, Lars C, Helness, Anne, Vadnais, Charles, Makishima, Hideki, Hönes, Judith M, Robert, François, Vassen, Lothar, Thivakaran, Aniththa, Al-Matary, Yahya, Lams, Robert F, Schütte, Judith, Giebel, Bernd, Görgens, André, Heuser, Michael, Medyouf, Hind, Maciejewski, Jaroslaw, Dührsen, Ulrich, Möröy, Tarik, Khandanpour, Cyrus

“…Epigenetic changes can contribute to development of acute myeloid leukemia (AML), a malignant disease of the bone marrow. A single-nucleotide polymorphism of…”
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GFI1's role in DNA repair suggests implications for tumour cell response to treatment by Vadnais, Charles, Möröy, Tarik

“…Despite recent advances in cancer treatment through personalized and precision medicine and new avenues such as immunotherapy and chimeric antibodies, the…”
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Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure by Sansregret, Laurent, Vadnais, Charles, Livingstone, Julie, Kwiatkowski, Nicholas, Awan, Arif, Cadieux, Chantal, Leduy, Lam, Hallett, Michael T, Nepveu, Alain

“…Cell populations able to generate a large repertoire of genetic variants have increased potential to generate tumor cells that survive through the multiple…”
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Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types by CADIEUX, Chantal, KEDINGER, Valérie, LU YAO, VADNAIS, Charles, DROSSOS, Maria, PAQUET, Marilène, NEPVEU, Alain

“…The p75 and p110 isoforms of the CUX1 homeodomain protein are overexpressed in breast tumors and cancer cell lines. To assess and compare the ability of these…”
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p110 CUX1 Cooperates with E2F Transcription Factors in the Transcriptional Activation of Cell Cycle-Regulated Genes by Truscott, Mary, Harada, Ryoko, Vadnais, Charles, Robert, François, Nepveu, Alain

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers by Vadnais, Charles, Shooshtarizadeh, Peiman, Rajadurai, Charles V, Lesurf, Robert, Hulea, Laura, Davoudi, Sayeh, Cadieux, Chantal, Hallett, Michael, Park, Morag, Nepveu, Alain

“…Autocrine activation of the Wnt/β-catenin pathway occurs in several cancers, notably in breast tumors, and is associated with higher expression of various Wnt…”
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Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on theENCODE array by Vadnais, Charles, Awan, Arif A, Harada, Ryoko, Clermont, Pier-Luc, Leduy, Lam, Bñrubñ, Ginette, Nepveu, Alain

“…Abstract Background Overexpression of the Cut homeobox 1 gene, CUX1 , inverselycorrelates with patient survival in breast cancers. Cell-based assays…”
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Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice by Siam, Rania, Harada, Ryoko, Cadieux, Chantal, Battat, Robert, Vadnais, Charles, Nepveu, Alain

“…Lats1 (large tumor suppressor 1) codes for a serine/threonine kinase that plays a role in the progression through mitosis. Genetic studies demonstrated that…”
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Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1) by Fraszczak, Jennifer, Arman, Kaifee Mohammad, Lacroix, Marion, Vadnais, Charles, Gaboury, Louis, Möröy, Tarik

“…Abstract GFI1 is a DNA-binding transcription factor that regulates hematopoiesis by repressing target genes through its association with complexes containing…”
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