Search Results - "Vadivel Gnanasundram, Sivakumar"

Translation Stress Regulates Ribosome Synthesis and Cell Proliferation by Vadivel Gnanasundram, Sivakumar, Fåhraeus, Robin

“…Ribosome and protein synthesis are major metabolic events that control cellular growth and proliferation. Impairment in ribosome biogenesis pathways and mRNA…”
Get full text

p53 mRNA Metabolism Links with the DNA Damage Response by Vadivel Gnanasundram, Sivakumar, Bonczek, Ondrej, Wang, Lixiao, Chen, Sa, Fahraeus, Robin

“…Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function…”
Get full text

DNA and RNA Binding Proteins: From Motifs to Roles in Cancer by Bonczek, Ondrej, Wang, Lixiao, Gnanasundram, Sivakumar Vadivel, Chen, Sa, Haronikova, Lucia, Zavadil-Kokas, Filip, Vojtesek, Borivoj

“…DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate…”
Get full text

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress by Gnanasundram, Sivakumar Vadivel, Pyndiah, Slovénie, Daskalogianni, Chrysoula, Armfield, Kate, Nylander, Karin, Wilson, Joanna B., Fåhraeus, Robin

“…The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore…”
Get full text

Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue by Gu, Xiaolian, Wang, Lixiao, Coates, Philip J, Gnanasundram, Sivakumar Vadivel, Sgaramella, Nicola, Sörlin, Jonas, Erdogan, Baris, Magan, Mustafa, Nylander, Karin

“…Oral cancer is a paradigm of Slaughter's concept of field cancerization, where tumors are thought to originate within an area of cells containing genetic…”
Get full text

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures by Fusée, Leila, Salomao, Norman, Ponnuswamy, Anand, Wang, Lixiao, López, Ignacio, Chen, Sa, Gu, Xiaolian, Polyzoidis, Stavros, Vadivel Gnanasundram, Sivakumar, Fahraeus, Robin

“…Cellular stress conditions activate p53-dependent pathways to counteract the inflicted damage. To achieve the required functional diversity, p53 is subjected…”
Get full text

A single synonymous mutation determines the phosphorylation and stability of the nascent protein by Karakostis, Konstantinos, Vadivel Gnanasundram, Sivakumar, López, Ignacio, Thermou, Aikaterini, Wang, Lixiao, Nylander, Karin, Olivares-Illana, Vanesa, Fåhraeus, Robin

“…p53 is an intrinsically disordered protein with a large number of post-translational modifications and interacting partners. The hierarchical order and…”
Get full text

Fast protein-depletion system utilizing tetracycline repressible promoter and N-end rule in yeast by Gnanasundram, Sivakumar Vadivel, Koš, Martin

“…A protein depletion by promoter shutoff or protein destabilization is an important tool in investigation of functions of essential genes. Various approaches…”
Get full text

Cryptic AUG is important for 48S ribosomal assembly during internal initiation of translation of coxsackievirus B3 RNA by Verma, Bhupendra, Ponnuswamy, Anand, Gnanasundram, Sivakumar Vadivel, Das, Saumitra

“…We have investigated the possible role of a conserved cis-acting element, the cryptic AUG, present in the 5' UTR of coxsackievirus B3 (CVB3 ) RNA. CVB3 5' UTR…”
Get full text

Targeted delivery of hepatitis C virus-specific short hairpin RNA in mouse liver using Sendai virosomes by Subramanian, Nithya, Mani, Prashant, Roy, Swagata, Gnanasundram, Sivakumar Vadivel, Sarkar, Debi P, Das, Saumitra

“…1 Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India 2 Department of Biochemistry, University of Delhi, South…”
Get full text

Targeting Ribosome assembly on the HCV RNA using a small RNA molecule by Bhat, Prasanna, Gnanasundram, Sivakumar Vadivel, Mani, Prashant, Ray, Partho Sarothi, Sarkar, Debi P, Das, Saumitra

“…Translation initiation of hepatitis C Virus (HCV) RNA is the initial obligatory step of the viral life cycle, mediated through the Internal Ribosome Entry Site…”
Get full text

At least two molecules of the RNA helicase Has1 are simultaneously present in pre-ribosomes during ribosome biogenesis by Gnanasundram, Sivakumar Vadivel, Kos-Braun, Isabelle C, Koš, Martin

“…Abstract The RNA helicase Has1 is involved in the biogenesis of both small and large ribosomal subunits. How it performs these separate roles is not fully…”
Get full text

MDM2’s dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities by Gnanasundram, Sivakumar Vadivel, Malbert-Colas, Laurence, Chen, Sa, Fusée, Leila, Daskalogianni, Chrysoula, Muller, Petr, Salomao, Norman, Fåhraeus, Robin

“…Abstract Cell growth requires a high level of protein synthesis and oncogenic pathways stimulate cell proliferation and ribosome biogenesis. Less is known…”
Get full text

PI3Kδ delta activates E2F1 synthesis in response to mRNA translation stress by Gnanasundram, Sivakumar Vadivel, Pyndiah, Slovenie, Daskalogianni, Chrysoula, Armfield, Kate, Nylander, Karin, Wilson, Joanna B., Fåhraeus, Robin

“…The  c-myc  oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore…”
Get full text