Neonatal Cerebral Venous Thrombosis following Maternal SARS-CoV-2 Infection in Pregnancy

A possible consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the development of an exacerbated thrombophilic status, and cerebral venous thrombosis (CVT) is a rare but possible complication of SARS-CoV-2 infection reported both in adults and in children. The pr...

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Bibliographic Details
Published in:	Neonatology (Basel, Switzerland) Vol. 119; no. 2; p. 268
Main Authors:	Campi, Francesca, Longo, Daniela, Bersani, Iliana, Savarese, Immacolata, Lucignani, Giulia, Haass, Cristina, Paolino, Maria Chiara, Vadalà, Sarah, De Liso, Paola, Di Capua, Matteo, Luciani, Matteo, Esposito, Giacomo, Amante, Paolina Giuseppina, Vigevano, Federico, Dotta, Andrea
Format:	Journal Article
Language:	English
Published:	Switzerland 01-03-2022
Subjects:	Adult Child COVID-19 - complications Family Female Humans Infant, Newborn Infectious Disease Transmission, Vertical Intracranial Thrombosis - diagnostic imaging Intracranial Thrombosis - etiology Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Outcome SARS-CoV-2 Venous Thrombosis - complications Pregnancy SARS-CoV-2 Neonate Magnetic resonance imaging Cerebral venous thrombosis
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Summary:	A possible consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the development of an exacerbated thrombophilic status, and cerebral venous thrombosis (CVT) is a rare but possible complication of SARS-CoV-2 infection reported both in adults and in children. The present case report describes the clinical course of a term neonate showing extended CVT of unclear origin, whose mother had developed SARS-CoV-2 infection during the third trimester of pregnancy. We speculate that the prothrombotic status induced by maternal SARS-CoV-2 infection may have played a pathophysiological role in the development of such severe neonatal complication. Further investigations are required to confirm such hypothesis.
ISSN:	1661-7819
DOI:	10.1159/000520537