Search Results - "Vadakath, Rahul"

Gα13 restricts nutrient driven proliferation in mucosal germinal centers by Nguyen, Hang T., Li, Moyi, Vadakath, Rahul, Henke, Keirstin A., Tran, Tam C., Li, Huifang, Yamadi, Maryam, Darbha, Sriranjani, Yang, Yandan, Kabat, Juraj, Albright, Anne R., Centeno, Enoc Granados, Phelan, James D., Roulland, Sandrine, Huang, Da Wei, Kelly, Michael C., Young, Ryan M., Pittaluga, Stefania, Difilippantonio, Simone, Muppidi, Jagan R.

“…Germinal centers (GCs) that form in mucosal sites are exposed to gut-derived factors that have the potential to influence homeostasis independent of antigen…”
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Abstract 4605: Chronic VEGF-C signaling exacerbates the progression of non-alcoholic steatohepatitis and hepatocarcinoma through endothelial VEGFR2 and VEGFR3 by Youn, Seock-Won, Eng, Jason W.-L., Swaminathan, Bhairavi, Teneqexhi, Pamela, Vadakath, Rahul, Kitajewski, Jan K.

“…Obesity, aging, and metabolic diseases contribute to non-alcoholic fatty liver disease (NAFLD) that can progress to non-alcoholic steatohepatitis (NASH) due to…”
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Abstract 247: Targeting Notch4 with a novel neutralizing antibody inhibits tumor growth and alters immune cell populations within the tumor microenvironment by Eng, Jason, Naiche, L.A., Swaminathan, Bhairavi, Kato, Yu, Thakkar, Krishna, Vadakath, Rahul, Herts, James, Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan

“…Endothelial Notch signaling is critical for tumor angiogenesis and growth. Inhibition of Notch1 or its ligand, Dll4, can induce tumor vessel hypersprouting,…”
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Abstract LB009: Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment by Eng, Jason W., Naiche, L.A., Swaminathan, Bhairavi, Kato, Yu, Thakkar, Krishna, Alexander, Katherine Ann, Vadakath, Rahul, Herts, James H., Emmadi, Rajyasree, Matsui, Junji, Kitajewski, Jan K.

“…The Notch signaling pathway, particularly endothelial Notch signaling, plays a key role in tumor formation and angiogenesis. Inhibiting Notch1 or its ligand,…”
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Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium by Eng, Jason W-L, Kato, Yu, Adachi, Yusuke, Swaminathan, Bhairavi, Naiche, L A, Vadakath, Rahul, Sakamoto, Yoshimasa, Nakazawa, Youya, Tachino, Sho, Ito, Ken, Abe, Takanori, Minoshima, Yukinori, Hoshino-Negishi, Kana, Ogasawara, Hideaki, Kawakatsu, Tomomi, Nishimura, Miyuki, Katayama, Masahiko, Shimizu, Masashi, Tahara, Kazuhiro, Sato, Toshitaka, Suzuki, Katsuhisa, Agarwala, Kishan, Iwata, Masao, Nomoto, Kenichi, Ozawa, Yoichi, Imai, Toshio, Funahashi, Yasuhiro, Matsui, Junji, Kitajewski, Jan

“…Endothelial Notch signaling is critical for tumor angiogenesis. Notch1 blockade can interfere with tumor vessel function but causes tissue hypoxia and…”
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