Search Results - "Vachet, Richard W"

Probing protein structure by amino acid-specific covalent labeling and mass spectrometry by Mendoza, Vanessa Leah, Vachet, Richard W

“…For many years, amino acid-specific covalent labeling has been a valuable tool to study protein structure and protein interactions, especially for systems that…”
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Intracellular Activation of Bioorthogonal Nanozymes through Endosomal Proteolysis of the Protein Corona by Zhang, Xianzhi, Liu, Yuanchang, Gopalakrishnan, Sanjana, Castellanos-Garcia, Laura, Li, Gengtan, Malassiné, Morgane, Uddin, Imad, Huang, Rui, Luther, David C, Vachet, Richard W, Rotello, Vincent M

“…Bioorthogonal activation of prodrugs provides a strategy for on-demand on-site production of therapeutics. Intracellular activation provides a strategy to…”
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Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles by Elci, Sukru Gokhan, Jiang, Ying, Yan, Bo, Kim, Sung Tae, Saha, Krishnendu, Moyano, Daniel F, Yesilbag Tonga, Gulen, Jackson, Liam C, Rotello, Vincent M, Vachet, Richard W

“…Surface chemistry plays a deciding role in nanoparticle biodistribution, yet very little is known about how surface chemistry influences the suborgan…”
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Interaction between Oxide Nanoparticles and Biomolecules of the Bacterial Cell Envelope As Examined by Infrared Spectroscopy by Jiang, Wei, Yang, Kun, Vachet, Richard W, Xing, Baoshan

“…The effects of Al2O3, TiO2, and ZnO nanoparticles (NPs) on bacteria cells and bacterial surface biomolecules were studied by Fourier transform infrared (FTIR)…”
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Enhanced Laser Desorption/Ionization Mass Spectrometric Detection of Biomolecules Using Gold Nanoparticles, Matrix, and the Coffee Ring Effect by Marsico, Alyssa L. M, Duncan, Bradley, Landis, Ryan F, Tonga, Gulen Yesilbag, Rotello, Vincent M, Vachet, Richard W

“…Nanomaterials have been extensively used as alternate matrices to minimize the low molecular weight interferences observed in typical MALDI but such…”
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Multiplexed Imaging of Nanoparticles in Tissues Using Laser Desorption/Ionization Mass Spectrometry by Yan, Bo, Kim, Sung Tae, Kim, Chang Soo, Saha, Krishnendu, Moyano, Daniel F, Xing, Yuqing, Jiang, Ying, Roberts, Amy L, Alfonso, Felix S, Rotello, Vincent M, Vachet, Richard W

“…Imaging of nanomaterials in biological tissues provides vital information for the development of nanotherapeutics and diagnostics. Multiplexed imaging of…”
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Dual-Mode Mass Spectrometric Imaging for Determination of in Vivo Stability of Nanoparticle Monolayers by Elci, S. Gokhan, Yesilbag Tonga, Gulen, Yan, Bo, Kim, Sung Tae, Kim, Chang Soo, Jiang, Ying, Saha, Krishnendu, Moyano, Daniel F, Marsico, Alyssa L. M, Rotello, Vincent M, Vachet, Richard W

“…Effective correlation of the in vitro and in vivo stability of nanoparticle-based platforms is a key challenge in their translation into the clinic. Here, we…”
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Covalent labeling and mass spectrometry reveal subtle higher order structural changes for antibody therapeutics by Limpikirati, Patanachai, Hale, John E, Hazelbaker, Mark, Huang, Yongbo, Jia, Zhiguang, Yazdani, Mahdieh, Graban, Eric M, Vaughan, Robert C, Vachet, Richard W

“…Monoclonal antibodies are among the fastest growing therapeutics in the pharmaceutical industry. Detecting higher-order structure changes of antibodies upon…”
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Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry by Zhu, Zheng-Jiang, Ghosh, Partha S., Miranda, Oscar R., Vachet, Richard W., Rotello, Vincent M.

“…Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into cells of interest. We describe for the first time the multiplexed…”
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Surface Properties Dictate Uptake, Distribution, Excretion, and Toxicity of Nanoparticles in Fish by Zhu, Zheng-Jiang, Carboni, Rachel, Quercio Jr, Michael J., Yan, Bo, Miranda, Oscar R., Anderton, Douglas L., Arcaro, Kathleen F., Rotello, Vincent M., Vachet, Richard W.

“…Monolayer‐protected gold nanoparticles (AuNPs) were used to demonstrate how surface chemistry influences the uptake, distribution, and excretion of…”
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Selective enrichment and sensitive detection of peptide and protein biomarkers in human serum using polymeric reverse micelles and MALDI-MS by Rodthongkum, Nadnudda, Ramireddy, Rajasekhar, Thayumanavan, S, Richard, W Vachet

“…Reverse-micelle forming amphiphilic homopolymers with carboxylic acid and quaternary amine substituents are used to selectively enrich biomarker peptides and…”
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Covalent labeling-mass spectrometry with non-specific reagents for studying protein structure and interactions by Limpikirati, Patanachai, Liu, Tianying, Vachet, Richard W.

“…•Covalent labeling-mass spectrometry can study protein structure and protein interactions.•The method primarily reports on the solvent accessibility of amino…”
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Covalent Labeling with Diethylpyrocarbonate: Sensitive to the Residue Microenvironment, Providing Improved Analysis of Protein Higher Order Structure by Mass Spectrometry by Limpikirati, Patanachai, Pan, Xiao, Vachet, Richard W

“…Covalent labeling with mass spectrometry is increasingly being used for the structural analysis of proteins. Diethylpyrocarbonate (DEPC) is a simple to use,…”
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Electron transfer dissociation of modified peptides and proteins by Zhou, Yuping, Dong, Jia, Vachet, Richard W

“…Mass spectrometry is the method of choice for sequencing peptides and proteins and is the preferred choice for characterizing post-translational modifications…”
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Gas-Phase Unfolding of Protein Complexes Distinguishes Conformational Isomers by Nash, Stacey, Vachet, Richard W.

“…Proteins can adopt different conformational states that are important for their biological function and, in some cases, can be responsible for their…”
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Synergistic Structural Information from Covalent Labeling and Hydrogen–Deuterium Exchange Mass Spectrometry for Protein–Ligand Interactions by Liu, Tianying, Limpikirati, Patanachai, Vachet, Richard W

“…Hydrogen–deuterium exchange (HDX) mass spectrometry (MS) and covalent labeling (CL) MS are typically considered to be complementary methods for protein…”
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MEMBRANE PROTEIN STRUCTURES AND INTERACTIONS FROM COVALENT LABELING COUPLED WITH MASS SPECTROMETRY by Pan, Xiao, Vachet, Richard W.

“…Membrane proteins are incredibly important biomolecules because they mediate interactions between a cell's external and internal environment. Obtaining…”
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Laser desorption/ionization mass spectrometry analysis of monolayer-protected gold nanoparticles by Yan, Bo, Zhu, Zheng-Jiang, Miranda, Oscar R, Chompoosor, Apiwat, Rotello, Vincent M, Vachet, Richard W

“…Monolayer-protected gold nanoparticles (AuNPs) feature unique surface properties that enable numerous applications. Thus, there is a need for simple, rapid,…”
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Multiplatform Metabolomics Studies of Human Cancers With NMR and Mass Spectrometry Imaging by Zhong, Anya B, Muti, Isabella H, Eyles, Stephen J, Vachet, Richard W, Sikora, Kristen N, Bobst, Cedric E, Calligaris, David, Stopka, Sylwia A, Agar, Jeffery N, Wu, Chin-Lee, Mino-Kenudson, Mari A, Agar, Nathalie Y R, Christiani, David C, Kaltashov, Igor A, Cheng, Leo L

“…The status of metabolomics as a scientific branch has evolved from proof-of-concept to applications in science, particularly in medical research. To…”
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Utilization of Hydrophobic Microenvironment Sensitivity in Diethylpyrocarbonate Labeling for Protein Structure Prediction by Biehn, Sarah E, Limpikirati, Patanachai, Vachet, Richard W, Lindert, Steffen

“…Diethylpyrocarbonate (DEPC) labeling analyzed with mass spectrometry can provide important insights into higher order protein structures. It has been…”
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