Search Results - "Vaccaro, María I."

Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death by Grasso, Daniel, Ropolo, Alejandro, Lo Ré, Andrea, Boggio, Verónica, Molejón, María I., Iovanna, Juan L., Gonzalez, Claudio D., Urrutia, Raúl, Vaccaro, María I.

“…Autophagy has recently elicited significant attention as a mechanism that either protects or promotes cell death, although different autophagy pathways, and…”
Get full text

VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins by Maiztegui, Bárbara, Boggio, Verónica, Román, Carolina L, Flores, Luis E, Zotto, Héctor Del, Ropolo, Alejandro, Grasso, Daniel, Vaccaro, María I, Gagliardino, Juan J

“…The aim of the present study was to demonstrate the role of autophagy and incretins in the fructose-induced alteration of β-cell mass and function. Normal…”
Get more information

Autophagy and Pancreas Disease by Vaccaro, María I

“…Abstract Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which has been known for its role in protecting…”
Get full text

Decoding the Versatile Landscape of Autophagic Protein VMP1 in Cancer: A Comprehensive Review across Tissue Types and Regulatory Mechanisms by Renna, Felipe J, Gonzalez, Claudio D, Vaccaro, Maria I

“…Autophagy, a catabolic process orchestrating the degradation of proteins and organelles within lysosomes, is pivotal for maintaining cellular homeostasis…”
Get full text

The VMP1-Beclin 1 interaction regulates autophagy induction by Molejon, Maria I., Ropolo, Alejandro, Re, Andrea Lo, Boggio, Veronica, Vaccaro, Maria I.

“…The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the…”
Get full text

Autophagy in Inflammatory Response against SARS-CoV-2 by Resnik, Roxana, Lopez Mingorance, Fabiana, Rivera, Francisco, Mitchell, Florencia, Gonzalez, Claudio D, Vaccaro, Maria I

“…The coronavirus disease pandemic, which profoundly reshaped the world in 2019 (COVID-19), and is currently ongoing, has affected over 200 countries, caused…”
Get full text

The emerging role of autophagy in the pathophysiology of diabetes mellitus by Gonzalez, Claudio D., Lee, Myung-Shik, Marchetti, Piero, Pietropaolo, Massimo, Towns, Roberto, Vaccaro, Maria I., Watada, Hirotaka, Wiley, John W.

“…An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of…”
Get full text

Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions by Gonzalez, Claudio D., Carro Negueruela, María Paula, Nicora Santamarina, Catalina, Resnik, Roxana, Vaccaro, Maria I.

“…Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology. At…”
Get full text

Ubiquitination Is a Novel Post-Translational Modification of VMP1 in Autophagy of Human Tumor Cells by Renna, Felipe J, Enriqué Steinberg, Juliana H, Gonzalez, Claudio D, Manifava, Maria, Tadic, Mariana S, Orquera, Tamara, Vecino, Carolina V, Ropolo, Alejandro, Guardavaccaro, Daniele, Rossi, Mario, Ktistakis, Nicholas T, Vaccaro, Maria I

“…Autophagy is a tightly regulated catabolic process involved in the degradation and recycling of proteins and organelles. Ubiquitination plays an important role…”
Get full text

The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells by Ropolo, Alejandro, Grasso, Daniel, Pardo, Romina, Sacchetti, Maria L., Archange, Cendrine, Re, Andrea Lo, Seux, Mylene, Nowak, Jonathan, Gonzalez, Claudio D., Iovanna, Juan L., Vaccaro, Maria I.

“…Autophagy is a degradation process of cytoplasmic cellular constituents, which serves as a survival mechanism in starving cells, and it is characterized by…”
Get full text

Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis by Vanasco, Virginia, Ropolo, Alejandro, Grasso, Daniel, Ojeda, Diego S, García, María Noé, Vico, Tamara A, Orquera, Tamara, Quarleri, Jorge, Alvarez, Silvia, Vaccaro, María I

“…Mitophagy and zymophagy are selective autophagy pathways early induced in acute pancreatitis that may explain the mild, auto limited, and more frequent…”
Get full text

A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS by Ropolo, Alejandro, Catrinacio, Cintia, Renna, Felipe Javier, Boggio, Veronica, Orquera, Tamara, Gonzalez, Claudio D., Vaccaro, Maria I.

“…Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which participates in cell response to disease. We…”
Get full text

Zymophagy: Selective Autophagy of Secretory Granules by Vaccaro, Maria I.

“…Timing is everything. That's especially true when it comes to the activation of enzymes created by the pancreas to break down food. Pancreatic enzymes are…”
Get full text

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells by Lo Ré, Andrea E., Fernández-Barrena, Maite G., Almada, Luciana L., Mills, Lisa D., Elsawa, Sherine F., Lund, George, Ropolo, Alejandro, Molejon, Maria I., Vaccaro, Maria I., Fernandez-Zapico, Martin E.

“…Background: Autophagy plays a role in cancer development. Results: Oncogenic KRAS induces Vacuole Membrane Protein 1 (VMP1) through a novel AKT1-GLI3-p300…”
Get full text

Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth by Ropolo, Alejandro, Tomasini, Richard, Grasso, Daniel, Dusetti, Nelson J, Cerquetti, Marı́a C, Iovanna, Juan L, Vaccaro, Marı́a I

“…We describe the cloning and expression of the mouse gene interferon-inducible-protein 15 (IP15), whose activation is related to the acute phase of experimental…”
Get full text

Gemcitabine Induces the VMP1 -Mediated Autophagy Pathway to Promote Apoptotic Death in Human Pancreatic Cancer Cells by Pardo, Romina, Lo Ré, Andrea, Archange, Cendrine, Ropolo, Alejandro, Papademetrio, Daniela L, Gonzalez, Claudio D, Alvarez, Elida M, Iovanna, Juan L, Vaccaro, Maria I

“…Abstract Background/Aim: Autophagy is a degradation process of cytoplasmic cellular constituents. We have described the vacuole membrane protein-1 (VMP1) whose…”
Get full text

Editorial: Autophagy: From Big Data to Physiological Significance by Sarkar, Sovan, Vaccaro, Maria I, Nezis, Ioannis P

Get full text

ER–plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis by Nascimbeni, Anna Chiara, Giordano, Francesca, Dupont, Nicolas, Grasso, Daniel, Vaccaro, Maria I, Codogno, Patrice, Morel, Etienne

“…The double‐membrane‐bound autophagosome is formed by the closure of a structure called the phagophore, origin of which is still unclear. The endoplasmic…”
Get full text

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations by Deretic, Vojo, Prossnitz, Eric, Burge, Mark, Campen, Matthew J., Cannon, Judy, Liu, Ke Jian, Sklar, Larry A., Allers, Lee, Garcia, Sally Ann, Baehrecke, Eric H., Behrends, Christian, Cecconi, Francesco, Codogno, Patrice, Chen, Guang-Chao, Elazar, Zvulun, Eskelinen, Eeva-Liisa, Fourie, Bernard, Gozuacik, Devrim, Hong, Wanjin, Hotamisligi, Gokhan, Jäättelä, Marja, Jo, Eun-Kyeong, Johansen, Terje, Juhász, Gábor, Kimchi, Adi, Ktistakis, Nicholas, Kroemer, Guido, MIzushima, Noboru, Münz, Christian, Reggiori, Fulvio, Rubinsztein, David, Ryan, Kevin, Schroder, Kate, Simonsen, Anne, Tooze, Sharon, I. Vaccaro, Maria, Yoshimori, Tamotsu, Yu, Li, Zhang, Hong, Klionsky, Daniel J.

“…Recently, NIH has funded a center for autophagy research named the Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence,…”
Get full text

Critical Role of USP9X in Initial Steps of VMP1-Mediated Autophagy by Vaccaro, Maria I, Grasso, Daniel, Renna, Felipe

Get full text