Search Results - "Vacca, Michele"

Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease by Azzu, Vian, Vacca, Michele, Virtue, Samuel, Allison, Michael, Vidal-Puig, Antonio

“…Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous,…”
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Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention by Bishehsari, Faraz, Mahdavinia, Mahboobeh, Vacca, Michele, Malekzadeh, Reza, Mariani-Costantini, Renato

“…Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem…”
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Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis by Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Queen, Rachel, Younes, Ramy, Vacca, Michele, Alexander, Leigh, Ravaioli, Federico, Palmer, Jeremy, Petta, Salvatore, Boursier, Jerome, Rosso, Chiara, Johnson, Katherine, Wonders, Kristy, Day, Christopher P, Ekstedt, Mattias, Orešič, Matej, Darlay, Rebecca, Cordell, Heather J, Marra, Fabio, Vidal-Puig, Antonio, Bedossa, Pierre, Schattenberg, Jörn M, Clément, Karine, Allison, Michael, Bugianesi, Elisabetta, Ratziu, Vlad, Daly, Ann K, Anstee, Quentin M

“…The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely understood. This large multicenter study characterized the…”
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Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma by Hall, Zoe, Chiarugi, Davide, Charidemou, Evelina, Leslie, Jack, Scott, Emma, Pellegrinet, Luca, Allison, Michael, Mocciaro, Gabriele, Anstee, Quentin M., Evan, Gerard I., Hoare, Matthew, Vidal‐Puig, Antonio, Oakley, Fiona, Vacca, Michele, Griffin, Julian L.

“…Background and Aims Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma…”
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Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions by Leslie, Jack, Geh, Daniel, Elsharkawy, Ahmed M., Mann, Derek A., Vacca, Michele

“…HCV hijacks many host metabolic processes in an effort to aid viral replication. The resulting hepatic metabolic dysfunction underpins many of the hepatic and…”
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Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction by Horckmans, Michael, Bianchini, Mariaelvy, Santovito, Donato, Megens, Remco T.A, Springael, Jean-Yves, Negri, Irene, Vacca, Michele, Di Eusanio, Marco, Moschetta, Antonio, Weber, Christian, Duchene, Johan, Steffens, Sabine

“…BACKGROUND:The pericardial adipose tissue (AT) contains a high density of lymphoid clusters. It is unknown whether these clusters play a role in…”
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Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease by Hall, Zoe, Bond, Nicholas J., Ashmore, Tom, Sanders, Francis, Ament, Zsuzsanna, Wang, Xinzhu, Murray, Andrew J., Bellafante, Elena, Virtue, Sam, Vidal‐Puig, Antonio, Allison, Michael, Davies, Susan E., Koulman, Albert, Vacca, Michele, Griffin, Julian L.

“…Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH),…”
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Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption by Sanders, Francis W B, Acharjee, Animesh, Walker, Celia, Marney, Luke, Roberts, Lee D, Imamura, Fumiaki, Jenkins, Benjamin, Case, Jack, Ray, Sumantra, Virtue, Samuel, Vidal-Puig, Antonio, Kuh, Diana, Hardy, Rebecca, Allison, Michael, Forouhi, Nita, Murray, Andrew J, Wareham, Nick, Vacca, Michele, Koulman, Albert, Griffin, Julian L

“…Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty…”
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Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor–null mice by intestinal‐specific farnesoid X receptor reactivation by Degirolamo, Chiara, Modica, Salvatore, Vacca, Michele, Di Tullio, Giuseppe, Morgano, Annalisa, D'Orazio, Andria, Kannisto, Kristina, Parini, Paolo, Moschetta, Antonio

“…Farnesoid X receptor (FXR) is the master regulator of bile acid (BA) homeostasis because it controls BA synthesis, influx, efflux, and detoxification in the…”
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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state by Belenguer, Germán, Mastrogiovanni, Gianmarco, Pacini, Clare, Hall, Zoe, Dowbaj, Anna M., Arnes-Benito, Robert, Sljukic, Aleksandra, Prior, Nicole, Kakava, Sofia, Bradshaw, Charles R., Davies, Susan, Vacca, Michele, Saeb-Parsy, Kourosh, Koo, Bon-Kyoung, Huch, Meritxell

“…RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown…”
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Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle by McNally, Ben D., Ashley, Dean F., Hänschke, Lea, Daou, Hélène N., Watt, Nicole T., Murfitt, Steven A., MacCannell, Amanda D. V., Whitehead, Anna, Bowen, T. Scott, Sanders, Francis W. B., Vacca, Michele, Witte, Klaus K., Davies, Graeme R., Bauer, Reinhard, Griffin, Julian L., Roberts, Lee D.

“…The endoplasmic reticulum (ER) regulates cellular protein and lipid biosynthesis. ER dysfunction leads to protein misfolding and the unfolded protein response…”
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Liver X Receptors Inhibit Proliferation of Human Colorectal Cancer Cells and Growth of Intestinal Tumors in Mice by Lo Sasso, Giuseppe, Bovenga, Fabiola, Murzilli, Stefania, Salvatore, Lorena, Di Tullio, Giuseppe, Martelli, Nicola, D'Orazio, Andria, Rainaldi, Stefania, Vacca, Michele, Mangia, Anita, Palasciano, Giuseppe, Moschetta, Antonio

“…Background & Aims Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and…”
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Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome by Mocciaro, Gabriele, D'Amore, Simona, Jenkins, Benjamin, Kay, Richard, Murgia, Antonio, Herrera-Marcos, Luis Vicente, Neun, Stefanie, Sowton, Alice P, Hall, Zoe, Palma-Duran, Susana Alejandra, Palasciano, Giuseppe, Reimann, Frank, Murray, Andrew, Suppressa, Patrizia, Sabbà, Carlo, Moschetta, Antonio, Koulman, Albert, Griffin, Julian L, Vacca, Michele

“…The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors characterised by central obesity, atherogenic dyslipidaemia, and changes in the…”
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Identification of peculiar gene expression profile in peripheral blood mononuclear cells (PBMC) of celiac patients on gluten free diet by Sangineto, Moris, Graziano, Giusi, D'Amore, Simona, Salvia, Roberto, Palasciano, Giuseppe, Sabbà, Carlo, Vacca, Michele, Cariello, Marica

“…Celiac disease (CD) is a systemic disorder characterized by an immune-mediated reaction to gluten and a wide spectrum of clinical manifestations. Currently,…”
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Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL) by Mocciaro, Gabriele, Allison, Michael, Jenkins, Benjamin, Azzu, Vian, Huang-Doran, Isabel, Herrera-Marcos, Luis Vicente, Hall, Zoe, Murgia, Antonio, Susan, Davies, Frontini, Mattia, Vidal-Puig, Antonio, Koulman, Albert, Griffin, Julian L., Vacca, Michele

“…Non-alcoholic fatty liver disease (NAFLD) develops due to impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis…”
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let-7e downregulation characterizes early phase colonic adenoma in APCMin/+ mice and human FAP subjects by Contursi, Annalisa, Arconzo, Maria, Cariello, Marica, Piglionica, Marilidia, D'Amore, Simona, Vacca, Michele, Graziano, Giusi, Gadaleta, Raffaella Maria, Valanzano, Rosa, Mariani-Costantini, Renato, Villani, Gaetano, Moschetta, Antonio, Piccinin, Elena

“…The crypt-villus axis represents the essential unit of the small intestine, which integrity and functions are fundamental to assure tissue and whole-body…”
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Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat by Brunetti, Luigi, Di Nisio, Chiara, Recinella, Lucia, Chiavaroli, Annalisa, Leone, Sheila, Ferrante, Claudio, Orlando, Giustino, Vacca, Michele

“…► 24h after adipokines administration, feeding and gene expression were analyzed. ► Vaspin decreased food intake, while chemerin and omentin-1 had no effect. ►…”
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Peripheral chemerin administration modulates hypothalamic control of feeding by Brunetti, Luigi, Orlando, Giustino, Ferrante, Claudio, Recinella, Lucia, Leone, Sheila, Chiavaroli, Annalisa, Di Nisio, Chiara, Shohreh, Rugia, Manippa, Fabio, Ricciuti, Adriana, Vacca, Michele

“…•Peripheral chemerin administration decreased food intake and body weight.•Chemerin decreased AgRP and orexin A mRNA in the hypothalamus.•Chemerin increased…”
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Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse by Piccinin, Elena, Arconzo, Maria, Graziano, Giusi, Vacca, Michele, Peres, Claudia, Bellafante, Elena, Villani, Gaetano, Moschetta, Antonio

“…The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome…”
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Nuclear receptors in regenerating liver and hepatocellular carcinoma by Vacca, Michele, Degirolamo, Chiara, Massafra, Vittoria, Polimeno, Lorenzo, Mariani-Costantini, Renato, Palasciano, Giuseppe, Moschetta, Antonio

“…► Nuclear receptors are master transcriptional regulators of liver development, differentiation and function. ► Nuclear receptors are keystone actors of…”
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