Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival

The aim of this study was to evaluate cathepsin D as a prognostic marker in invasive bladder cancer and to determine its relationship with stage, grade, lymph-node metastasis and survival too. An immunohistochemical staining of 32 radical cystectomy specimens suffering from transitional cell carcino...

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Bibliographic Details
Published in:	Actas urologicas españolas Vol. 26; no. 5; p. 335
Main Authors:	Carrascosa Lloret, C, Cremades Mira, A, Sánchez Sanchis, M, Rodrigo Guanter, V, Beltrán Armada, J R, Sala Aznar, A, Vacacela Córdova, R, Coronel Sánchez, B, Clar Blanch, F, Tarin Planes, M, Sanjuán de Laorden, C
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-05-2002
Subjects:	Adult Aged Biomarkers, Tumor Carcinoma, Transitional Cell - chemistry Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Cathepsin D - analysis Chi-Square Distribution Cystectomy Data Interpretation, Statistical Female Humans Immunohistochemistry Lymphatic Metastasis Male Middle Aged Prognosis Time Factors Urinary Bladder - chemistry Urinary Bladder - pathology Urinary Bladder Neoplasms - chemistry Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology
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Summary:	The aim of this study was to evaluate cathepsin D as a prognostic marker in invasive bladder cancer and to determine its relationship with stage, grade, lymph-node metastasis and survival too. An immunohistochemical staining of 32 radical cystectomy specimens suffering from transitional cell carcinoma was performed, using a monoclonal antibody anti-cathepsin D (Novocastra). We made a semicuantitative measurement of the cathepsin D expression in the tumor and in the peritumoral stroma in a 400 x microscopic high power field. Patient population was composed of 31 men and 1 woman with a mean age of 63.25 years. The mean follow up was 23.6 months. Stage was classified with the WHO 1997 classification. Grade was classified with the ISUP/WHO 1998 classification. For the statistical analysis the Chi-square test, Pearson's test R, the Kaplan Meier method and the log-rank test were used. The pathological stages of the surgical specimens were as follows: pTo:3.1% (1), pT1:12.5% (4), pT2:15.6% (5), pT3:34.4% (11). (p < 0.001) A high cytologic grade was found in 81.25% of the tumors. There was a 43.8% progression rate and 40.6% mortality. There was no statistically significant relationship among Cathepsin's D levels in the stroma and lymph node metastases, stage, or grade (p = 0.473, p = 0.604, p = 0.2423). There was no statistically significant relationship among Cathepsin's D levels in the tumor and lymph node metastases, stage or grade (p = 0.496, p = 0.722 and p = 0.461). The cathepsin D levels, neither in the stroma nor in the tumor, showed no influence neither on the disease free intervals nor in the survival rates (p = 0.785; p = 0.355 and p = 0.614; p = 0.601 respectively). Immunohistochemical Cathepsin D levels do not seem to play a role in the prognostic of transitional tumors of the urinary bladder.
ISSN:	0210-4806