Search Results - "Vaananen, H. Kalervo"

Bone turnover markers and prediction of fracture: A prospective follow‐up study of 1040 elderly women for a mean of 9 years by Ivaska, Kaisa K, Gerdhem, Paul, Väänänen, H Kalervo, Åkesson, Kristina, Obrant, Karl J

“…Osteoporosis is characterized by compromised bone mass and strength, predisposing to an increased risk of fracture. Increased bone metabolism has been…”
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Monocyte-Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators by Haerkoenen, Pirkko L, Vaeaenaenen, HKalervo

“…:  Postmenopausal decline of estrogen production is associated with development of several degenerative disorders such as osteoporosis, neuroinflammatory…”
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FGF‐8 is involved in bone metastasis of prostate cancer by Valta, Maija P., Tuomela, Johanna, Bjartell, Anders, Valve, Eeva, Väänänen, H. Kalervo, Härkönen, Pirkko

“…Prostate cancer is the most common malignancy of men in Western countries. Patients with advanced prostate cancer suffer from incurable bone metastases. Recent…”
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Removal of Osteoclast Bone Resorption Products by Transcytosis by Salo, Jari, Lehenkari, Petri, Mulari, Mika, Metsikkö, Kalervo, Väänänen, H. Kalervo

“…Osteoclasts are multinucleated cells responsible for bone resorption. During the resorption cycle, osteoclasts undergo dramatic changes in their polarity, and…”
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Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats by Nurmio, Mirja, Joki, Henna, Kallio, Jenny, Määttä, Jorma A., Väänänen, H. Kalervo, Toppari, Jorma, Jahnukainen, Kirsi, Laitala-Leinonen, Tiina

“…During postnatal skeletal growth, adaptation to mechanical loading leads to cellular activities at the growth plate. It has recently become evident that bone…”
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The critical role of IL-34 in osteoclastogenesis by Chen, Zhi, Buki, Kalman, Vääräniemi, Jukka, Gu, Guoliang, Väänänen, H Kalervo

“…It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also known as CSF-1) and RANKL. Recently, a novel cytokine,…”
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Improved methods for testing antiresorptive compounds in human osteoclast cultures by Rissanen, Jukka P, Ylipahkala, Hannele, Fagerlund, Katja M, Long, Clive, Väänänen, H. Kalervo, Halleen, Jussi M

“…We cultured human bone marrow-derived stem cells on bovine bone slices in 96-well plates in the presence of M-CSF and RANKL, allowing them to differentiate…”
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Osteoclast lineage and function by Väänänen, H. Kalervo, Laitala-Leinonen, Tiina

“…Osteoclasts are members of the monocyte/macrophage lineage and are formed by cellular fusions from their mononuclear precursors. Their differentiation is…”
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Urinary osteocalcin is a useful marker for monitoring the effect of alendronate therapy by IVASKA, Kaisa K, PETTERSSON, Kim, NENONEN, Arja, UUSI-RASI, Kirsti, HEINONEN, Ari, KANNUS, Pekka, KALERVO VÄÄNÄNEN, H

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Inhibition of the osteoclast V-ATPase by small interfering RNAs by Hu, Yingwei, Nyman, Jonas, Muhonen, Pirkko, Väänänen, H. Kalervo, Laitala-Leinonen, Tiina

“…The multisubunit enzyme V-ATPase harbours isoforms of individual subunits. a3 is one of four 116 kDa subunit a isoforms, and it is crucial for bone resorption…”
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A Novel Immunoassay for The Determination of Tartrate‐Resistant Acid Phosphatase 5b From Rat Serum by Alatalo, Sari L, Peng, Zhiqi, Janckila, Anthony J, Kaija, Helena, Vihko, Pirkko, Väänänen, H Kalervo, Halleen, Jussi M

“…Osteoclasts secrete tartrate‐resistant acid phosphatase 5b (TRACP 5b) into the circulation. We have developed an immunoassay for the determination of rat TRACP…”
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Novel interaction of Rab13 and Rab8 with endospanins by Hirvonen, Mirkka J., Büki, Kálmán G., Sun, Yi, Mulari, Mika T.K., Härkönen, Pirkko L., Väänänen, Kalervo H.

“…Rab GTPases regulate vesicular traffic in eukaryotic cells by cycling between the active GTP-bound and inactive GDP-bound states. Their functions are modulated…”
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Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition by Merrell, Melinda, Suarez-Cuervo, Catalina, Harris, Kevin W, Väänänen, H Kalervo, Selander, Katri S

“…Bisphosphonates (BPs) inhibit osteoclast-mediated bone resorption. They also protect from cancer-induced osteolysis and inhibit breast cancer growth in vitro…”
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Mesenchymal stem cells by Väänänen, H Kalervo

“…About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to…”
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Identification of novel proteolytic forms of osteocalcin in human urine by Ivaska, Kaisa K, Hellman, Jukka, Likojärvi, Johanna, Käkönen, Sanna-Maria, Gerdhem, Paul, Åkesson, Kristina, Obrant, Karl J, Pettersson, Kim, Kalervo Väänänen, H

“…In this study, we report the isolation and characterization of osteocalcin in human urine using mass spectrometry and N-terminal sequencing. Multiple…”
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Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women by Lu, Chunyan, Ivaska, Kaisa K, Alen, Markku, Wang, Qingju, Törmäkangas, Timo, Xu, Leiting, Wiklund, Petri, Mikkola, Tuija M, Pekkala, Satu, Tian, Haoming, Väänänen, H. Kalervo, Cheng, Sulin

“…Context: The skeleton is recognized as an important player in energy metabolism through its interactions with other tissues. Whether the association of…”
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Estrogen and Testosterone Use Different Cellular Pathways to Inhibit Osteoclastogenesis and Bone Resorption by Michael, Husheem, Härkönen, Pirkko L, Väänänen, H Kalervo, Hentunen, Teuvo A

“…Using human peripheral blood CD14+ osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological…”
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Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption by Halleen, Jussi M, Tiitinen, Sari L, Ylipahkala, Hannele, Fagerlund, Katja M, Väänänen, H Kalervo

“…Tartrate-resistant acid phosphatase (TRACP) is an enzyme that is expressed in high amounts by bone resorbing osteoclasts, inflammatory macrophages and…”
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Associations Between Homocysteine, Bone Turnover, BMD, Mortality, and Fracture Risk in Elderly Women by Gerdhem, Paul, Ivaska, Kaisa K, Isaksson, Anders, Pettersson, Kim, Väänänen, H Kalervo, Obrant, Karl J, Åkesson, Kristina

“…Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from the OPRA study, high homocysteine…”
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Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial by Cheng, Sulin, Lyytikäinen, Arja, Kröger, Heikki, Lamberg-Allardt, Christel, Alén, Markku, Koistinen, Arvo, Wang, Qing Ju, Suuriniemi, Miia, Suominen, Harri, Mahonen, Anitta, Nicholson, Patrick HF, Ivaska, Kaisa K, Korpela, Riitta, Ohlsson, Claes, Väänänen, Kalervo H, Tylavsky, Frances

“…BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone…”
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