Search Results - "Vaňourková, Zdenka"

Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula by Kala, Petr, Vaňourková, Zdenka, Škaroupková, Petra, Kompanowska-Jezierska, Elżbieta, Sadowski, Janusz, Walkowska, Agnieszka, Veselka, Josef, Táborský, Miloš, Maxová, Hana, Vaněčková, Ivana, Červenka, Luděk

“…Association of congestive heart failure (CHF) and chronic kidney disease (CKD) worsens the patient’s prognosis and results in poor survival rate. The aim of…”
Get full text

Deleterious Effects of Hyperactivity of the Renin-Angiotensin System and Hypertension on the Course of Chemotherapy-Induced Heart Failure after Doxorubicin Administration: A Study in Ren-2 Transgenic Rat by Kala, Petr, Bartušková, Hana, Piťha, Jan, Vaňourková, Zdenka, Kikerlová, Soňa, Jíchová, Šárka, Melenovský, Vojtěch, Hošková, Lenka, Veselka, Josef, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Gawrys, Olga, Maxová, Hana, Červenka, Luděk

“…Doxorubicin's (DOX) cardiotoxicity contributes to the development of chemotherapy-induced heart failure (HF) and new treatment strategies are in high demand…”
Get full text

Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension by Červenka, Luděk, Husková, Zuzana, Kopkan, Libor, Kikerlová, Soňa, Sedláková, Lenka, Vaňourková, Zdenka, Alánová, Petra, Kolář, František, Hammock, Bruce D, Hwang, Sung H, Imig, John D, Falck, John R, Sadowski, Janusz, Kompanowska-Jezierska, Elzbieta, Neckář, Jan

“…OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given…”
Get full text

Impairment of the angiotensin-converting enzyme 2–angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension by Bürgelová, Marcela, Vaňourková, Zdenka, Thumová, Monika, Dvořák, Pavel, Opočenský, Martin, Kramer, Herbert J, Želízko, Michal, Malý, Jan, Bader, Michael, Červenka, Luděk

“…OBJECTIVERecent studies have shown that the heptapeptide angiotensin-(1-7) [Ang-(1-7)] exerts important vasoactive actions and can act as an endogenous…”
Get full text

Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats by Hrdlička, Jaroslav, Neckář, Jan, Papoušek, František, Husková, Zuzana, Kikerlová, Soňa, Vaňourková, Zdenka, Vernerová, Zdenka, Akat, Firat, Vašinová, Jana, Hammock, Bruce D, Hwang, Sung Hee, Imig, John D, Falck, John R, Červenka, Luděk, Kolář, František

“…Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we…”
Get full text

Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice by Červenka, Luděk, Vaněčková, Ivana, Husková, Zuzana, Vaňourková, Zdenka, Erbanová, Michaela, Thumová, Monika, Škaroupková, Petra, Opočenský, Martin, Malý, Jan, Chábová, Věra Čertíková, Tesař, Vladimír, Bürgelová, Marcela, Viklický, Ondřej, Teplan, Vladimír, Želízko, Michal, Kramer, Herbert J, Navar, L Gabriel

“…OBJECTIVEThe present study was performed to examine in two-kidney, one-clip (2K1C) Goldblatt hypertensive micefirst, the relative contribution of angiotensin…”
Get full text

Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats by Walkowska, Agnieszka, Škaroupková, Petra, Husková, Zuzana, Vaňourková, Zdenka, Chábová, Věra Čertíková, Tesař, Vladimír, Kramer, Herbert J, Falck, John R, Imig, John D, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Červenka, Luděk

“…OBJECTIVEThe contribution of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) as cytochrome P-450 metabolites of arachidonic acid…”
Get full text

Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats by Erbanová, Michaela, Thumová, Monika, Husková, Zuzana, Vaněčková, Ivana, Vaňourková, Zdenka, Mullins, John J, Kramer, Herbert J, Bürgelová, Marcela, Rakušan, Dan, Červenka, Luděk

“…OBJECTIVEThe present study was performed to characterize the autoregulatory efficiency of renal blood flow and glomerular filtration rate and the…”
Get full text

Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats by Chábová, Věra Čertíková, Kramer, Herbert J, Vaněčková, Ivana, Vernerová, Zdena, Eis, Václav, Tesař, Vladimír, Škaroupková, Petra, Thumová, Monika, Schejbalová, Stanislava, Husková, Zuzana, Vaňourková, Zdenka, Kolský, Alexander, Imig, John D, Červenka, Luděk

“…Abstract The aim of the present study was to evaluate the effects of inhibition of cytochrome P-450 (CYP) activity by 1-aminobenzotriazole (ABT) and by CoCl2 ,…”
Get full text

AT1 receptor blocker, but not an ACE inhibitor, prevents kidneys from hypoperfusion during congestive heart failure in normotensive and hypertensive rats by Kratky, Vojtech, Vanourkova, Zdenka, Sykora, Matus, Bacova, Barbara Szeiffova, Hruskova, Zdenka, Kikerlova, Sona, Huskova, Zuzana, Kopkan, Libor

“…To provide novel insights into the pathogenesis of heart failure-induced renal dysfunction, we compared the effects of ACE inhibitor (ACEi) and AT 1 receptor…”
Get full text

Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension by Hojná, Silvie, Rauchová, Hana, Malínská, Hana, Marková, Irena, Hüttl, Martina, Papoušek, František, Behuliak, Michal, Miklánková, Denisa, Vaňourková, Zdeňka, Neckář, Jan, Kadlecová, Michaela, Kujal, Petr, Zicha, Josef, Vaněčková, Ivana

“…The new antidiabetic drugs, gliflozins, inhibit sodium-glucose transporter-2 in renal proximal tubules promoting glucose and sodium excretion. This leads not…”
Get full text

Hepatoprotective and cardioprotective effects of empagliflozin in spontaneously hypertensive rats fed a high-fat diet by Hojná, Silvie, Malínská, Hana, Hüttl, Martina, Vaňourková, Zdeňka, Marková, Irena, Miklánková, Denisa, Hrdlička, Jaroslav, Papoušek, František, Neckář, Jan, Kujal, Petr, Behuliak, Michal, Rauchová, Hana, Kadlecová, Michaela, Sedmera, David, Neffeová, Kristýna, Zábrodská, Eva, Olejníčková, Veronika, Zicha, Josef, Vaněčková, Ivana

“…A combination of liver and heart dysfunction worsens the prognosis of human survival. The aim of this study was to investigate whether empagliflozin (a…”
Get full text

Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension by Kala, Petr, Gawrys, Olga, Miklovič, Matúš, Vaňourková, Zdenka, Škaroupková, Petra, Jíchová, Šárka, Sadowski, Janusz, Kompanowska-Jezierska, Elzbieta, Walkowska, Agnieszka, Veselka, Josef, Táborský, Miloš, Maxová, Hana, Vaněčková, Ivana, Červenka, Luděk

“…Evaluation of the effect of endothelin type A (ET A ) receptor blockade on the course of volume-overload heart failure in rats with angiotensin II-dependent…”
Get full text

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula by Honetschlägerová, Zuzana, Husková, Zuzana, Kikerlová, Soňa, Sadowski, Janusz, Kompanowska-Jezierska, Elzbieta, Táborský, Miloš, Vaňourková, Zdenka, Kujal, Petr, Červenka, Luděk

“…The aim was to evaluate the effects of renal denervation (RDN) on autoregulation of renal hemodynamics and the pressure-natriuresis relationship in Ren-2…”
Get full text

Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula by Honetschlagerová, Zuzana, Gawrys, Olga, Jíchová, Šárka, Škaroupková, Petra, Kikerlová, Soňa, Vaňourková, Zdeňka, Husková, Zuzana, Melenovský, Vojtěch, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Kolář, František, Novotný, Jiří, Hejnová, Lucie, Kujal, Petr, Červenka, Luděk

“…Objective: We examined if renal denervation (RDN) attenuates the progression of aortocaval fistula (ACF)-induced heart failure or improves renal hemodynamics…”
Get full text

The treatment with sGC stimulator improves survival of hypertensive rats in response to volume-overload induced by aorto-caval fistula by Gawrys, Olga, Husková, Zuzana, Škaroupková, Petra, Honetschlägerová, Zuzana, Vaňourková, Zdeňka, Kikerlová, Soňa, Melenovský, Vojtěch, Bačová, Barbara Szeiffová, Sykora, Matúš, Táborský, Miloš, Červenka, Luděk

“…Heart failure (HF) has been declared as global pandemic and current therapies are still ineffective, especially in patients that develop concurrent…”
Get full text

Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model by Miklovič, Matúš, Gawryś, Olga, Honetschlägerová, Zuzana, Kala, Petr, Husková, Zuzana, Kikerlová, Soňa, Vaňourková, Zdeňka, Jíchová, Šárka, Kvasilová, Alena, Kitamoto, Misuzu, Maxová, Hana, Puertas-Frias, Guillermo, Mráček, Tomáš, Sedmera, David, Melenovský, Vojtěch

“…Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is…”
Get full text

Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats by Gawrys, Olga, Husková, Zuzana, Baranowska, Iwona, Walkowska, Agnieszka, Sadowski, Janusz, Kikerlová, Soňa, Vaňourková, Zdeňka, Honetschlägerová, Zuzana, Škaroupková, Petra, Červenka, Luděk, Falck, John R., Imig, John D., Kompanowska-Jezierska, Elzbieta

“…OBJECTIVES:The global morbidity and mortality related to hypertension and associated disorders increases continuously and novel therapeutic strategies are…”
Get full text

The exaggerated salt-sensitive response in hypertensive transgenic rats (TGR mRen-2) fostered by a normotensive female by Svitok, Pavel, Husková, Zuzana, Červenková, Lenka, Kikerlová, Soňa, Vaňourková, Zdenka, Sedláková, Lenka, Vacková, Šárka, Šutovska, Hana, Zeman, Michal, Kopkan, Libor

“…Suboptimal conditions during prenatal and early postnatal development can increase risk of hypertension later in life. We studied consequences of a changed…”
Get full text

Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease by Hojná, Silvie, Kotsaridou, Zoe, Vaňourková, Zdeňka, Rauchová, Hana, Behuliak, Michal, Kujal, Petr, Kadlecová, Michaela, Zicha, Josef, Vaněčková, Ivana

“…Gliflozins (sodium-glucose transporter-2 inhibitors) exhibited renoprotective effects not only in diabetic but also in non-diabetic patients with chronic…”
Get full text