Search Results - "VYSE, Timothy J"

Genetic advances in systemic lupus erythematosus: an update by Chen, Lingyan, Morris, David L, Vyse, Timothy J

“…PURPOSE OF REVIEWMore than 80 susceptibility loci are now reported to show robust genetic association with systemic lupus erythematosus (SLE). The differential…”
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Complement C4, the Major Histocompatibility Complex, and Autoimmunity by Vyse, Timothy J., Tsao, Betty P.

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Autophagy is activated in systemic lupus erythematosus and required for plasmablast development by Clarke, Alexander J, Ellinghaus, Ursula, Cortini, Andrea, Stranks, Amanda, Simon, Anna Katharina, Botto, Marina, Vyse, Timothy J

“…Autophagy has emerged as a critical homeostatic mechanism in T lymphocytes, influencing proliferation and differentiation. Autophagy in B cells has been less…”
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Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups by Wang, Yong-Fei, Zhang, Yan, Lin, Zhiming, Zhang, Huoru, Wang, Ting-You, Cao, Yujie, Morris, David L., Sheng, Yujun, Yin, Xianyong, Zhong, Shi-Long, Gu, Xiaoqiong, Lei, Yao, He, Jing, Wu, Qi, Shen, Jiangshan Jane, Yang, Jing, Lam, Tai-Hing, Lin, Jia-Huang, Mai, Zhi-Ming, Guo, Mengbiao, Tang, Yuanjia, Chen, Yanhui, Song, Qin, Ban, Bo, Mok, Chi Chiu, Cui, Yong, Lu, Liangjing, Shen, Nan, Sham, Pak C., Lau, Chak Sing, Smith, David K., Vyse, Timothy J., Zhang, Xuejun, Lau, Yu Lung, Yang, Wanling

“…Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among…”
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Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells by Halim, Timotheus Y.F., Rana, Batika M.J., Walker, Jennifer A., Kerscher, Bernhard, Knolle, Martin D., Jolin, Helen E., Serrao, Eva M., Haim-Vilmovsky, Liora, Teichmann, Sarah A., Rodewald, Hans-Reimer, Botto, Marina, Vyse, Timothy J., Fallon, Padraic G., Li, Zhi, Withers, David R., McKenzie, Andrew N.J.

“…The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced…”
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COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection by Wang, Yuxuan, Guga, Suri, Wu, Kejia, Khaw, Zoe, Tzoumkas, Konstantinos, Tombleson, Phil, Comeau, Mary E, Langefeld, Carl D, Cunninghame Graham, Deborah S, Morris, David L, Vyse, Timothy J

“…Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with…”
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Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus by Odhams, Christopher A., Roberts, Amy L., Vester, Susan K., Duarte, Carolina S. T., Beales, Charlie T., Clarke, Alexander J., Lindinger, Sonja, Daffern, Samuel J., Zito, Antonino, Chen, Lingyan, Jones, Leonardo L., Boteva, Lora, Morris, David L., Small, Kerrin S., Fernando, Michelle M. A., Cunninghame Graham, Deborah S., Vyse, Timothy J.

“…Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking…”
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C-reactive protein in rheumatology: biology and genetics by Rhodes, Benjamin, Fürnrohr, Barbara G., Vyse, Timothy J.

“…Serum level of C-reactive protein (CRP) is commonly measured in rheumatology practice, but it is perhaps less widely appreciated that CRP level is influenced…”
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Defining the role of the MHC in autoimmunity: a review and pooled analysis by Fernando, Michelle M A, Stevens, Christine R, Walsh, Emily C, De Jager, Philip L, Goyette, Philippe, Plenge, Robert M, Vyse, Timothy J, Rioux, John D

“…The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this…”
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Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus by Vyse, Timothy J, Cunninghame Graham, Deborah S

“…Prioritizing tag-SNPs carried on extended risk haplotypes at susceptibility loci for common disease is a challenge. We utilized trans-ancestral exclusion…”
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Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus by Cunninghame Graham, Deborah S, Morris, David L, Bhangale, Tushar R, Criswell, Lindsey A, Syvänen, Ann-Christine, Rönnblom, Lars, Behrens, Timothy W, Graham, Robert R, Vyse, Timothy J

“…Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes…”
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UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases by Lewis, Myles J., Vyse, Simon, Shields, Adrian M., Boeltz, Sebastian, Gordon, Patrick A., Spector, Timothy D., Lehner, Paul J., Walczak, Henning, Vyse, Timothy J.

“…UBE2L3 is associated with increased susceptibility to numerous autoimmune diseases, but the underlying mechanism is unexplained. By using data from a…”
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Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease by Odhams, Christopher A, Cunninghame Graham, Deborah S, Vyse, Timothy J

“…Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to…”
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Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus by Lewis, Myles J., McAndrew, Michael B., Wheeler, Colin, Workman, Nicholas, Agashe, Pooja, Koopmann, Jens, Uddin, Ezam, Morris, David L., Zou, Lu, Stark, Richard, Anson, John, Cope, Andrew P., Vyse, Timothy J.

“…The molecular targets of the vast majority of autoantibodies in systemic lupus erythematosus (SLE) are unknown. We set out to identify novel autoantibodies in…”
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Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans by Lessard, Christopher J., Sajuthi, Satria, Zhao, Jian, Kim, Kwangwoo, Ice, John A., Li, He, Ainsworth, Hannah, Rasmussen, Astrid, Kelly, Jennifer A., Marion, Miranda, Bang, So‐Young, Bin Joo, Young, Choi, Jeongim, Lee, Hye‐Soon, Mo Kang, Young, Suh, Chang‐Hee, Tae Chung, Won, Lee, Soo‐Kon, Choe, Jung‐Yoon, Cheol Shim, Seung, Hee Oh, Ji, Jin Kim, Young, Han, Bok‐Ghee, Shen, Nan, Siew Howe, Hwee, Wakeland, Edward K., Li, Quan‐Zhen, Wook Song, Yeong, Gaffney, Patrick M., Alarcón‐Riquelme, Marta E., Criswell, Lindsey A., Jacob, Chaim O., Kimberly, Robert P., Vyse, Timothy J., Harley, John B., Sivils, Kathy L., Bae, Sang‐Cheol, Langefeld, Carl D., Tsao, Betty P.

“…Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder whose etiology is incompletely understood, but likely involves environmental…”
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The genetics of lupus: a functional perspective by Guerra, Sandra G, Vyse, Timothy J, Cunninghame Graham, Deborah S

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of…”
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Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase by Jacob, Chaim O, Eisenstein, Miriam, Dinauer, Mary C, Ming, Wenyu, Liu, Qiang, John, Sutha, Quismorio, Francesco P., Jr, Reiff, Andreas, Myones, Barry L, Kaufman, Kenneth M, McCurdy, Deborah, Harley, John B, Silverman, Earl, Kimberly, Robert P, Vyse, Timothy J, Gaffney, Patrick M, Moser, Kathy L, Klein-Gitelman, Marisa, Wagner-Weiner, Linda, Langefeld, Carl D, Armstrong, Don L, Zidovetzki, Raphael

“…Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, is a debilitating multisystem autoimmune disorder characterized by chronic…”
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Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression by Hauberg, Mads Engel, Zhang, Wen, Giambartolomei, Claudia, Franzén, Oscar, Morris, David L., Vyse, Timothy J., Ruusalepp, Arno, Fromer, Menachem, Sieberts, Solveig K., Johnson, Jessica S., Ruderfer, Douglas M., Shah, Hardik R., Klei, Lambertus L., Dang, Kristen K., Perumal, Thanneer M., Logsdon, Benjamin A., Mahajan, Milind C., Mangravite, Lara M., Essioux, Laurent, Toyoshiba, Hiroyoshi, Gur, Raquel E., Hahn, Chang-Gyu, Lewis, David A., Haroutunian, Vahram, Peters, Mette A., Lipska, Barbara K., Buxbaum, Joseph D., Hirai, Keisuke, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela, Schadt, Eric E., Björkegren, Johan L.M., Roussos, Panos

“…Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved with traits and diseases. However, it is often unclear which genes…”
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A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap by Ramos, Paula S, Criswell, Lindsey A, Moser, Kathy L, Comeau, Mary E, Williams, Adrienne H, Pajewski, Nicholas M, Chung, Sharon A, Graham, Robert R, Zidovetzki, Raphael, Kelly, Jennifer A, Kaufman, Kenneth M, Jacob, Chaim O, Vyse, Timothy J, Tsao, Betty P, Kimberly, Robert P, Gaffney, Patrick M, Alarcón-Riquelme, Marta E, Harley, John B, Langefeld, Carl D

“…In spite of the well-known clustering of multiple autoimmune disorders in families, analyses of specific shared genes and polymorphisms between systemic lupus…”
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Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans by Roberts, Amy L, Morea, Alessandro, Amar, Ariella, Zito, Antonino, El-Sayed Moustafa, Julia S, Tomlinson, Max, Bowyer, Ruth C E, Zhang, Xinyuan, Christiansen, Colette, Costeira, Ricardo, Steves, Claire J, Mangino, Massimo, Bell, Jordana T, Wong, Chloe C Y, Vyse, Timothy J, Small, Kerrin S

“…Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor…”
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