Search Results - "VOUY LINH TRUONG"

Studies Directed toward Asymmetric Synthesis of Cardioactive Steroids via Anionic Polycyclization by Yang, Zhixiang, Shannon, Dean, Truong, Vouy-Linh, Deslongchamps, Pierre

“…The use of anionic polycyclization (AP) in constructing the steroidal backbone of cardenolides was investigated. The reaction of 2-carbomethoxy-2-cyclohexenone…”
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Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors by Iglesias, Jose, Lamontagne, Julien, Erb, Heidi, Gezzar, Sari, Zhao, Shangang, Joly, Erik, Truong, Vouy Linh, Skorey, Kathryn, Crane, Sheldon, Madiraju, S.R.Murthy, Prentki, Marc

“…Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing…”
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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K by Gauthier, Jacques Yves, Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Kimmel, Donald B., Lamontagne, Sonia, Léger, Serge, LeRiche, Tammy, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Nicoll-Griffith, Deborah A., Oballa, Renata M., Palmer, James T., Percival, M. David, Riendeau, Denis, Robichaud, Joel, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy-Linh, Venuti, Michael C., Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron

“…Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724…”
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme by THERIEN, Michel, SKOREY, Kathryn, ZAMBONI, Robert, CHUN SING LI, LAU, Cheuk K, LERICHE, Tammy, VOUY LINH TRUONG, WADDLETON, Deena, RAMACHANDRAN, Chidambaram

“…The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a…”
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Asymmetric Syntheses of 1-Aryl-2,2,2-trifluoroethylamines via Diastereoselective 1,2-Addition of Arylmetals to 2-Methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide by Truong, Vouy Linh, Ménard, Madelaine S, Dion, Isabelle

“…Condensation of N-tert-butanesulfinamide (S)-1 with trifluoroacetaldehyde hydrate 2a afforded 2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide 3…”
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Practical and efficient synthesis of N-fused tricyclic indoles by Koay, Natalie, Tonelli, Devin L., Truong, Vouy Linh

“…A practical and efficient synthesis of methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives 6 is reported. This synthetic approach featured the…”
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Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group by Bungard, Christopher J, Williams, Peter D, Ballard, Jeanine E, Bennett, David J, Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S, Chang, Ronald K, Dubost, David C, Fay, John F, Diamond, Tracy L, Greshock, Thomas J, Hao, Li, Holloway, M. Katharine, Felock, Peter J, Gesell, Jennifer J, Su, Hua-Poo, Manikowski, Jesse J, McKay, Daniel J, Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M, Nantermet, Philippe G, Nadeau, Christian, Sanchez, Rosa I, Satyanarayana, Tummanapalli, Shipe, William D, Singh, Sanjay K, Truong, Vouy Linh, Vijayasaradhi, Sivalenka, Wiscount, Catherine M, Vacca, Joseph P, Crane, Sheldon N, McCauley, John A

“…A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound…”
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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y₁₄ receptor antagonists by Guay, Daniel, Beaulieu, Christian, Belley, Michel, Crane, Sheldon N, DeLuca, Jeancarlo, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Chan, Chi Chung, Xu, Lijing, Gordon, Robert, Li, Lianhai, Mamane, Yael, Morin, Nicolas, Mancini, Joseph, Thérien, Michel, Tranmer, Geoffrey, Truong, Vouy Linh, Wang, Zhaoyin, Black, W. Cameron

“…A weak antagonist of the pyrimidinergic receptor P2Y₁₄ containing a dihydropyridopyrimidine core was identified through high-throughput screening. Subsequent…”
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The identification of potent, selective, and bioavailable cathepsin S inhibitors by Gauthier, Jacques Yves, Black, W. Cameron, Courchesne, Isabelle, Cromlish, Wanda, Desmarais, Sylvie, Houle, Robert, Lamontagne, Sonia, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Ouellet, Marc, Robichaud, Joël, Truchon, Jean-François, Truong, Vouy-Linh, Wang, Qingping, Percival, M. David

“…The Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Qué., Canada H9H 3L1. Highly potent, selective, and bioavailable…”
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Identification of a potent and selective non-basic cathepsin K inhibitor by Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron

“…Based on our previous study with trifluoroethylamine as a P2–P3 amide isostere of cathepsin K inhibitor, further optimization led to identification of compound…”
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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K by Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.

“…The trifluoroethylamine group found in cathepsin K inhibitors like odanacatib can be replaced by a difluoroethylamine group. This change increased the basicity…”
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Mild and efficient ligand-free copper-catalyzed condensation for the synthesis of quinazolines by Truong, Vouy Linh, Morrow, Michelle

“…Condensation of o-iodobenzaldehydes 1a– c with amidine hydrochlorides 2a– p under ligand-free copper-catalyzed Ullmann N-arylation conditions afforded the…”
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Selective isolation of in vitro phase II conjugates using a lipophilic anionic exchange solid phase extraction method by Gagné, Sébastien, Laterreur, Julie, Mahrouche, Louiza, Sørensen, Dan, Gauthier, Jacques Yves, Truong, Vouy Linh, Chauret, Nathalie, Lévesque, Jean-François

“…Identification, characterization and structure elucidation of human metabolites of drug candidates is crucial for the pharmaceutical industry to assess their…”
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Rhodium-catalyzed diastereoselective 1,2-addition of arylboronic acids to chiral trifluoroethyl imine by Truong, Vouy Linh, Pfeiffer, Jennifer Y.

“…Rhodium-catalyzed 1,2-addition of arylboronic acids 4a–j to chiral trifluoroethyl imine 3 afforded diastereomerically enriched sulfinamides 5a–j. The chiral…”
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Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500) by Black, W. Cameron, Abdoli, Abbas, An, Xiuli, Auger, Anick, Beaulieu, Patrick, Bernatchez, Michel, Caron, Cathy, Chefson, Amandine, Crane, Sheldon, Diallo, Mohamed, Dorich, Stéphane, Fader, Lee D., Ferraro, Gino B., Fournier, Sara, Gao, Qi, Ginzburg, Yelena, Hamel, Martine, Han, Yongshuai, Jones, Paul, Lanoix, Stéphanie, Lacbay, Cyrus M., Leclaire, Marie-Eve, Levy, Maayan, Mamane, Yael, Mulani, Amina, Papp, Robert, Pellerin, Charles, Picard, Audrey, Skeldon, Alexander, Skorey, Kathryn, Stocco, Rino, St.-Onge, Miguel, Truchon, Jean-François, Truong, Vouy Linh, Zimmermann, Michal, Zinda, Michael, Roulston, Anne

“…ATR is a key kinase in the DNA-damage response (DDR) that is synthetic lethal with several other DDR proteins, making it an attractive target for the treatment…”
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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases by Gallant, Michel, Beaulieu, Christian, Berthelette, Carl, Colucci, John, Crackower, Michael A., Dalton, Chad, Denis, Danielle, Ducharme, Yves, Friesen, Richard W., Guay, Daniel, Gervais, François G., Hamel, Martine, Houle, Robert, Krawczyk, Connie M., Kosjek, Birgit, Lau, Stephen, Leblanc, Yves, Lee, Ernest E., Levesque, Jean-François, Mellon, Christophe, Molinaro, Carmela, Mullet, Wayne, O’Neill, Gary P., O’Shea, Paul, Sawyer, Nicole, Sillaots, Susan, Simard, Daniel, Slipetz, Deborah, Stocco, Rino, Sørensen, Dan, Truong, Vouy Linh, Wong, Elizabeth, Wu, Jin, Zaghdane, Helmi, Wang, Zhaoyin

“…In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two…”
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor by Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron

“…MK-0674 is a potent and selective cathepsin K inhibitor from the same structural class as odanacatib with a comparable inhibitory potency profile against Cat…”
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Asymmetric Syntheses of 1-Aryl-2,2,2-trifluoroethylamines via Diastereoselective 1,2-Addition of Arylmetals to 2-Methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide by Truong, Vouy Linh, Ménard, Madeleine S, Dion, Isabelle

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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y sub(14 receptor antagonists) by Guay, Daniel, Beaulieu, Christian, Belley, Michel, Crane, Sheldon N, DeLuca, Jeancarlo, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Chan, Chi Chung, Xu, Lijing, Gordon, Robert, Li, Lianhai, Mamane, Yael, Morin, Nicolas, Mancini, Joseph, Therien, Michel, Tranmer, Geoffrey, Truong, Vouy Linh, Wang, Zhaoyin, Black, WCameron

“…A weak antagonist of the pyrimidinergic receptor P2Y sub(14 containing a dihydropyridopyrimidine core was identified through high-throughput screening…”
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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y 14 receptor antagonists by Guay, Daniel, Beaulieu, Christian, Belley, Michel, Crane, Sheldon N., DeLuca, Jeancarlo, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Chan, Chi Chung, Xu, Lijing, Gordon, Robert, Li, Lianhai, Mamane, Yael, Morin, Nicolas, Mancini, Joseph, Thérien, Michel, Tranmer, Geoffrey, Truong, Vouy Linh, Wang, Zhaoyin, Black, W. Cameron

“…A weak antagonist of the pyrimidinergic receptor P2Y 14 containing a dihydropyridopyrimidine core was identified through high-throughput screening. Subsequent…”
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