Search Results - "VOSKUHL, R. R"

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes by Itoh, Noriko, Itoh, Yuichiro, Tassoni, Alessia, Ren, Emily, Kaito, Max, Ohno, Ai, Ao, Yan, Farkhondeh, Vista, Johnsonbaugh, Hadley, Burda, Josh, Sofroniew, Michael V., Voskuhl, Rhonda R.

“…Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from…”
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Sex-related factors in multiple sclerosis susceptibility and progression by Voskuhl, Rhonda R., Gold, Stefan M.

“…The higher incidence of multiple sclerosis (MS) in women than in men is widely acknowledged in the literature. The role of sex-related factors is, therefore,…”
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Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis by Voskuhl, Rhonda R., Itoh, Noriko, Tassoni, Alessia, Matsukawa, Macy Akiyo, Ren, Emily, Tse, Vincent, Jang, Ellis, Suen, Timothy Takazo, Itoh, Yuichiro

“…Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the brain during health, and regional differences in the transcriptome…”
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Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis by Voskuhl, Rhonda R., MacKenzie-Graham, Allan

“…Animal models of multiple sclerosis (MS), specifically experimental autoimmune encephalomyelitis (EAE), have been used extensively to develop anti-inflammatory…”
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Cell specificity dictates similarities in gene expression in multiple sclerosis, Parkinson's disease, and Alzheimer's disease by Itoh, Yuichiro, Voskuhl, Rhonda R

“…Drug repurposing is an efficient approach in new treatment development since it leverages previous work from one disease to another. While multiple sclerosis…”
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XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis by Du, Sienmi, Itoh, Noriko, Askarinam, Sahar, Hill, Haley, Arnold, Arthur P., Voskuhl, Rhonda R.

“…Women are more susceptible to multiple sclerosis (MS) and have more robust immune responses than men. However, men with MS tend to demonstrate a more…”
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Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS by Voskuhl, Rhonda R, Peterson, R. Scott, Song, Bingbing, Ao, Yan, Morales, Laurie Beth J, Tiwari-Woodruff, Seema, Sofroniew, Michael V

“…Factors that regulate leukocyte entry and spread through CNS parenchyma during different types of CNS insults are incompletely understood. Reactive astrocytes…”
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Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice by Itoh, Noriko, Itoh, Yuichiro, Meyer, Cassandra E., Suen, Timothy Takazo, Cortez-Delgado, Diego, Rivera Lomeli, Michelle, Wendin, Sophia, Somepalli, Sri Sanjana, Golden, Lisa C., MacKenzie-Graham, Allan, Voskuhl, Rhonda R.

“…Menopause is associated with cognitive deficits and brain atrophy, but the brain region and cell-specific mechanisms are not fully understood. Here, we…”
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Neuroprotection mediated through estrogen receptor-α in astrocytes by Spence, Rory D., Hamby, Mary E., Umeda, Elizabeth, Itoh, Noriko, Du, Sienmi, Wisdom, Amy J., Cao, Yuan, Bondar, Galyna, Lam, Jeannie, Ao, Yan, Sandoval, Francisco, Suriany, Silvie, Sofroniew, Michael V., Voskuhl, Rhonda R.

“…Estrogen has well-documented neuroprotective effects in a variety of clinical and experimental disorders of the CNS, including autoimmune inflammation,…”
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Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE by Ziehn, Marina O, Avedisian, Andrea A, Tiwari-Woodruff, Seema, Voskuhl, Rhonda R

“…Over half of multiple sclerosis (MS) patients experience cognitive deficits, including learning and memory dysfunction, and the mechanisms underlying these…”
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Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production by Liva, Stephanie M, Voskuhl, Rhonda R

“…Males are less susceptible than females to experimental autoimmune encephalomyelitis and many other autoimmune diseases. Gender differences in cytokine…”
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Sex differences in brain atrophy in multiple sclerosis by Voskuhl, Rhonda R, Patel, Kevin, Paul, Friedemann, Gold, Stefan M, Scheel, Michael, Kuchling, Joseph, Cooper, Graham, Asseyer, Susanna, Chien, Claudia, Brandt, Alexander U, Meyer, Cassandra Eve, MacKenzie-Graham, Allan

“…Women are more susceptible to multiple sclerosis (MS) than men by a ratio of approximately 3:1. However, being male is a risk factor for worse disability…”
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A role for sex chromosome complement in the female bias in autoimmune disease by Smith-Bouvier, Deborah L, Divekar, Anagha A, Sasidhar, Manda, Du, Sienmi, Tiwari-Woodruff, Seema K, King, Jennifer K, Arnold, Arthur P, Singh, Ram Raj, Voskuhl, Rhonda R

“…Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we…”
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Differential Neuroprotective and Antiinflammatory Effects of Estrogen Receptor (ER)α and ERβ Ligand Treatment by Tiwari-Woodruff, Seema, Morales, Laurie Beth J., Lee, Ruri, Voskuhl, Rhonda R.

“…Treatment with either estradiol or an estrogen receptor (ER)α ligand has been shown to be both antiinflammatory and neuroprotective in a variety of…”
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Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice by Tiwari-Woodruff, Seema, Voskuhl, Rhonda R

“…Abstract Demyelination and neurodegeneration is a major contributor in the progression of disability in multiple sclerosis (MS). Thus, the development of…”
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Onset of multiple sclerosis associated with anti-TNF therapy by SICOTTE, Nancy L, VOSKUHL, Rhonda R

“…Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine implicated in autoimmune disease are effective, especially for rheumatoid…”
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Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Estriol by Soldan, Samantha S, Retuerto, Ana Isabel Alvarez, Sicotte, Nancy L, Voskuhl, Rhonda R

“…The protective effect of pregnancy on putative Th1-mediated autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, is associated with a Th1…”
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The effect of sex on multiple sclerosis risk and disease progression by Voskuhl, Rhonda R

“…Sex differences in the incidence or severity of disease characterize many autoimmune and neurodegenerative diseases. Multiple sclerosis is a complex disease…”
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Neuroprotective effects of testosterone treatment in men with multiple sclerosis by Kurth, Florian, Luders, Eileen, Sicotte, Nancy L, Gaser, Christian, Giesser, Barbara S, Swerdloff, Ronald S, Montag, Michael J, Voskuhl, Rhonda R, Mackenzie-Graham, Allan

“…Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. While current medication reduces relapses and…”
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Treatment of multiple sclerosis with the pregnancy hormone estriol by Sicotte, Nancy L., Liva, Stephanie M., Klutch, Rochelle, Pfeiffer, Paul, Bouvier, Seth, Odesa, Sylvia, Wu, T. C. Jackson, Voskuhl, Rhonda R.

“…Multiple sclerosis patients who become pregnant experience a significant decrease in relapses that may be mediated by a shift in immune responses from T helper…”
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