Search Results - "VORTMEYER, ALEXANDER O."

Activating KRAS mutations in arteriovenous malformations of the brain: frequency and clinicopathologic correlation by Priemer, David S., Vortmeyer, Alexander O., Zhang, Shaobo, Chang, Hsim Yee, Curless, Kendra L., Cheng, Liang

“…Arteriovenous malformations (AVM) of the brain are considered congenital. Most AVMs are presumably sporadic; however, rare familial cases occur and they may be…”
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Integrated genomic analyses of de novo pathways underlying atypical meningiomas by Harmancı, Akdes Serin, Youngblood, Mark W., Clark, Victoria E., Coşkun, Süleyman, Henegariu, Octavian, Duran, Daniel, Erson-Omay, E. Zeynep, Kaulen, Leon D., Lee, Tong Ihn, Abraham, Brian J., Simon, Matthias, Krischek, Boris, Timmer, Marco, Goldbrunner, Roland, Omay, S. Bülent, Baranoski, Jacob, Baran, Burçin, Carrión-Grant, Geneive, Bai, Hanwen, Mishra-Gorur, Ketu, Schramm, Johannes, Moliterno, Jennifer, Vortmeyer, Alexander O., Bilgüvar, Kaya, Yasuno, Katsuhito, Young, Richard A., Günel, Murat

“…Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and…”
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High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity by Lu, Yao, Chen, Jonathan J, Mu, Luye, Xue, Qiong, Wu, Yu, Wu, Pei-Hsun, Li, Jie, Vortmeyer, Alexander O, Miller-Jensen, Kathryn, Wirtz, Denis, Fan, Rong

“…Secreted proteins dictate a range of cellular functions in human health and disease. Because of the high degree of cellular heterogeneity and, more…”
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Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system by Al-Gharaibeh, S. Nayef, Temm, Constance J, Shively, Sharon B, Vortmeyer, Alexander O

“…Renal clear cell carcinoma commonly occurs in patients with von Hippel-Lindau disease (VHL). Kidneys of VHL disease patients (VHL kidneys) contain an abundance…”
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Characterization of Microscopic Multicellular Foci in Grossly Normal Renal Parenchyma of Von Hippel-Lindau Kidney by Al-Gharaibeh, Nayef S, Shively, Sharon B, Vortmeyer, Alexander O

“…: This study aims to describe the earliest renal lesions in patients with von Hippel-Lindau (VHL) disease, especially the multicellular microscopic pathologic…”
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Development of a histological pseudocapsule and its use as a surgical capsule in the excision of pituitary tumors by OLDFIELD, Edward H, VORTMEYER, Alexander O

“…The presence of a histological pseudocapsule around pituitary tumors was noted in the early 1900s. Since that time there has been no emphasis on the sequence…”
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Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain by PALMIERI, Diane, BRONDER, Julie L, VORTMEYER, Alexander O, STEINBERG, Seth M, ALDAPE, Kenneth, STEEG, Patricia S, HERRING, Jeanne M, YONEDA, Toshiyuki, WEIL, Robert J, STARK, Andreas M, KUREK, Raffael, VEGA-VALLE, Eleazar, FEIGENBAUM, Lionel, HALVERSON, Douglas

“…Retrospective studies of breast cancer patients suggest that primary tumor Her-2 overexpression or trastuzumab therapy is associated with a devastating…”
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Surgical Management of Carney Complex–Associated Pituitary Pathology by Lonser, Russell R., Mehta, Gautam U., Kindzelski, Bogdan A., Ray-Chaudhury, Abhik, Vortmeyer, Alexander O., Dickerman, Robert, Oldfield, Edward H.

“…Abstract BACKGROUND: Carney complex (CNC) is a familial neoplasia syndrome that is associated with pituitary-associated hypersecretion of growth hormone (GH)…”
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Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization by Fitzgerald, Daniel P., Palmieri, Diane, Hua, Emily, Hargrave, Elizabeth, Herring, Jeanne M., Qian, Yongzhen, Vega-Valle, Eleazar, Weil, Robert J., Stark, Andreas M., Vortmeyer, Alexander O., Steeg, Patricia S.

“…Interactions between tumor cells and the microenvironment are crucial to tumor formation and metastasis. The central nervous system serves as a “sanctuary”…”
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Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study by Simonyan, Kristina, Tovar-Moll, Fernanda, Ostuni, John, Hallett, Mark, Kalasinsky, Victor F., Lewin-Smith, Michael R., Rushing, Elisabeth J., Vortmeyer, Alexander O., Ludlow, Christy L.

“…Spasmodic dysphonia is a neurological disorder characterized by involuntary spasms in the laryngeal muscles during speech production. Although the clinical…”
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Radiologic and histologic consequences of radiosurgery for brain tumors by Alomari, Ahmed, Rauch, Philipp J., Orsaria, Maria, Minja, Frank J., Chiang, Veronica L., Vortmeyer, Alexander O.

“…Progressively enlarging encephalopathic changes are now well-documented effects of gamma knife radiosurgery (GKRS) occurring ~3–30 months after treatment of…”
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Delayed Radiation-Induced Vasculitic Leukoencephalopathy by Rauch, Philipp J., B.S, Park, Henry S., B.S, Knisely, Jonathan P.S., M.D, Chiang, Veronica L., M.D, Vortmeyer, Alexander O., M.D., Ph.D

“…Purpose Recently, single-fraction, high-dosed focused radiation therapy such as that administered by Gamma Knife radiosurgery has been used increasingly for…”
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Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult by Bryant, Jean-Paul, Chandrashekhar, Vikram, Cappadona, Anthony J., Lookian, Pashayar P., Chandrashekhar, Vibhu, Donahue, Danielle R., Munasinghe, Jeeva B., Kim, H. Jeffrey, Vortmeyer, Alexander O., Heiss, John D., Zhuang, Zhengping, Rosenblum, Jared S.

“…The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and…”
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F(ab)′ 2 -mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins by Basta, Milan, Van Goor, Fredric, Luccioli, Stefano, Billings, Eric M, Vortmeyer, Alexander O, Baranyi, Lajos, Szebeni, Janos, Alving, Carl R, Carroll, Michael C, Berkower, Ira, Stojilkovic, Stanko S, Metcalfe, Dean D

“…High-dose intravenous immunoglobulin (IVIG) prevents immune damage by scavenging complement fragments C3b and C4b. We tested the hypothesis that exogenous…”
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von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells by Park, Deric M, Zhuang, Zhengping, Chen, Ling, Szerlip, Nicholas, Maric, Irina, Li, Jie, Sohn, Taesung, Kim, Stephanie H, Lubensky, Irina A, Vortmeyer, Alexander O, Rodgers, Griffin P, Oldfield, Edward H, Lonser, Russell R

“…To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor…”
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The vestibular aqueduct : site of origin of endolymphatic sac tumors by LONSER, Russell R, BAGGENSTOS, Martin, KIM, H. Jeffrey, BUTMAN, John A, VORTMEYER, Alexander O

“…Although endolymphatic sac tumors (ELSTs) frequently destroy the posterior petrous bone and cause hearing loss, the anatomical origin of these neoplasms is…”
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Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats by DEGEN, Jeffrey W, WALBRIDGE, Stuart, VORTMEYER, Alexander O, OLDFIELD, Edward H, LONSER, Russell R

“…Convection-enhanced delivery (CED) can be used safely to perfuse regions of the central nervous system (CNS) with therapeutic agents in a manner that bypasses…”
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Tumors of the Endolymphatic Sac in von Hippel–Lindau Disease by Lonser, Russell R, Kim, H. Jeffrey, Butman, John A, Vortmeyer, Alexander O, Choo, Daniel I, Oldfield, Edward H

“…This Brief Report describes three patients with von Hippel–Lindau disease who had hearing loss due to a microscopic tumor of the endolymphatic sac. In two…”
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Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema by Urday, Sebastian, Kimberly, W. Taylor, Beslow, Lauren A., Vortmeyer, Alexander O., Selim, Magdy H., Rosand, Jonathan, Simard, J. Marc, Sheth, Kevin N.

“…Key Points Secondary injury following intracerebral haemorrhage (ICH) is caused by perihaemorrhagic inflammation, toxic products of blood breakdown, and…”
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Von Hippel-Lindau Disease: Current Challenges and Future Prospects by Gläsker, Sven, Vergauwen, Evelynn, Koch, Christian A, Kutikov, Alexander, Vortmeyer, Alexander O

“…Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In…”
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