Telomerase activity in oral leukoplakia and head and neck squamous cell carcinoma

The expression of telomerase, a ribonucleoprotein complex, is necessary to overcome cellular senescence, and it is associated with immortal cells and cancer. However, its role in precancerous lesions such as oral leukoplakias is less known. The purpose of this study is to investigate the presence of...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 56; no. 15; pp. 3530 - 3533
Main Authors:	MUTIRANGURA, A, SUPIYAPHUN, P, TRIREKAPAN, S, SRIURANPONG, V, SAKUNTABHAI, A, YENRUDI, S, VORADUD, N
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-08-1996
Subjects:	Adult Aged Aged, 80 and over Base Sequence Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Female Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - pathology Humans Leukoplakia, Oral - enzymology Leukoplakia, Oral - pathology Male Medical sciences Middle Aged Molecular Sequence Data Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Precancerous Conditions - enzymology Precancerous Conditions - pathology Telomerase - metabolism Tumors Human Squamous cell carcinoma Premalignant lesion Enzyme Pathogenesis Carcinogenesis Oral cavity Tissue Leukoplasia Enzymatic activity Head and neck ENT disease Telomerase
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Summary:	The expression of telomerase, a ribonucleoprotein complex, is necessary to overcome cellular senescence, and it is associated with immortal cells and cancer. However, its role in precancerous lesions such as oral leukoplakias is less known. The purpose of this study is to investigate the presence of telomerase activity in oral leukoplakia and the relationship between the enzyme and multistep tumorigenesis. Telomerase activity was detectable in 14 of 16 human head and neck squamous cell carcinomas and 10 of 26 oral leukoplakia tissues. We also showed that the expression of telomerase in the premalignant lesions was associated with phenotypic progression, the degree of dysplasia. These results indicate that telomerase is activated frequently during the late stage of oral premalignancy and may play a crucial role in head and neck squamous cell carcinogenesis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0008-5472 1538-7445