Search Results - "VOLZ, Astrid"
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Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers
Published in Drug metabolism and disposition (01-02-2014)“…Dabigatran etexilate, a double prodrug of dabigatran, is a reversible, competitive, direct thrombin inhibitor that has been approved for use in many countries…”
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Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system
Published in European journal of pharmaceutics and biopharmaceutics (01-05-2008)“…Purpose: To establish a fluorescent dye (Glutathione methylfluorescein, GSMF) based assay to rapidly screen compounds for drug efflux interactions with the…”
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Potent Cholesteryl Ester Transfer Protein Inhibitors of Reduced Lipophilicity: 1,1′-Spiro-Substituted Hexahydrofuroquinoline Derivatives
Published in Journal of medicinal chemistry (13-11-2014)“…A series of 1,1′-spiro-substituted hexahydrofuroquinoline derivatives exhibiting potent cholesteryl ester transfer protein (CETP) inhibition at reduced…”
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Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice
Published in European journal of pharmaceutical sciences (01-08-2002)“…The aim of the present study was to determine a potential impact of P-glycoprotein (P-gp) on the tissue distribution and disposition of apafant (WEB 2086, CAS…”
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Longevity of adult ventricular rat heart muscle cells in serum-free primary culture
Published in Journal of molecular and cellular cardiology (01-02-1991)“…The study had two aims: first, to improve the longevity of isolated adult cardiomyocytes in serum-free culture, and, second, to investigate whether…”
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