Search Results - "VOLPERT, Olga V"

miR-200b inhibits prostate cancer EMT, growth and metastasis by Williams, LaTanya V, Veliceasa, Dorina, Vinokour, Elena, Volpert, Olga V

“…miRNA regulate gene expression at post-transcriptional level and fine-tune the key biological processes, including cancer progression. Here, we demonstrate the…”
Get full text

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche by Plebanek, Michael P., Angeloni, Nicholas L., Vinokour, Elena, Li, Jia, Henkin, Anna, Martinez-Marin, Dalia, Filleur, Stephanie, Bhowmick, Reshma, Henkin, Jack, Miller, Stephen D., Ifergan, Igal, Lee, Yesung, Osman, Iman, Thaxton, C. Shad, Volpert, Olga V.

“…Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that…”
Get full text

PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro by Martinez-Marin, Dalia, Jarvis, Courtney, Nelius, Thomas, de Riese, Werner, Volpert, Olga V, Filleur, Stéphanie

“…Although inflammation and prostate cancer (PCa) have been linked, the molecular interactions between macrophages and PCa cells are poorly explored. Pigment…”
Get full text

Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor by Mirzoeva, Salida, Tong, Xin, Bridgeman, Bryan B., Plebanek, Michael P., Volpert, Olga V.

“…We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding…”
Get full text

Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention by Bridgeman, Bryan B., Wang, Pu, Ye, Boping, Pelling, Jill C., Volpert, Olga V., Tong, Xin

“…Ultraviolet B (UVB) radiation is the major environmental risk factor for developing skin cancer, the most common cancer worldwide, which is characterized by…”
Get full text

p53-Responsive miR-194 Inhibits Thrombospondin-1 and Promotes Angiogenesis in Colon Cancers by SUNDARAM, Prema, HULTINE, Stacy, THOMAS-TIKHONENKO, Andrei, SMITH, Lauren M, DEWS, Michael, FOX, Jamie L, BIYASHEV, Dauren, SCHELTER, Janell M, QIHONG HUANG, CLEARY, Michele A, VOLPERT, Olga V

“…Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal…”
Get full text

miR-27b controls venous specification and tip cell fate by Biyashev, Dauren, Veliceasa, Dorina, Topczewski, Jacek, Topczewska, Jolanta M., Mizgirev, Igor, Vinokour, Elena, Reddi, Alagarsamy L., Licht, Jonathan D., Revskoy, Sergei Y., Volpert, Olga V.

“…We discovered that miR-27b controls 2 critical vascular functions: it turns the angiogenic switch on by promoting endothelial tip cell fate and sprouting and…”
Get full text

Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts by Nwani, Nkechiyere G, Deguiz, Maria L, Jimenez, Benilde, Vinokour, Elena, Dubrovskyi, Oleksii, Ugolkov, Andrey, Mazar, Andrew P, Volpert, Olga V

“…Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal…”
Get full text

Androgen receptor drives cellular senescence by Mirochnik, Yelena, Veliceasa, Dorina, Williams, Latanya, Maxwell, Kelly, Yemelyanov, Alexander, Budunova, Irina, Volpert, Olga V

“…The accepted androgen receptor (AR) role is to promote proliferation and survival of prostate epithelium and thus prostate cancer progression. While…”
Get full text

Hepatocyte Growth Factor/Scatter Factor Mediates Angiogenesis through Positive VEGF and Negative Thrombospondin 1 Regulation by Zhang, Yu-Wen, Su, Yanli, Volpert, Olga V., George F. Vande Woude

“…Hepatocyte growth factor/scatter factor (HGF/SF), acting through the Met receptor, plays an important role in most human solid tumors, and inappropriate…”
Get full text

The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder? by Craword, Susan E, Fitchev, Philip, Veliceasa, Dorina, Volpert, Olga V

“…Pigment epithelium-derived factor (PEDF) was discovered as a neurotrophic factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as…”
Get more information

Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal Proteolysis by Ladhani, Omar, Sánchez-Martinez, Cristina, Orgaz, Jose L, Jimenez, Benilde, Volpert, Olga V

“…Abstract Metastatic melanoma cells are highly adaptable to their in vivo microenvironment and can switch between protease-dependent mesenchymal and…”
Get full text

Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor by Volpert, Olga V, Zaichuk, Tetiana, Zhou, Wei, Reiher, Frank, Ferguson, Thomas A, Stuart, P. Michael, Amin, Mohammad, Bouck, Noel P

“…Natural inhibitors of angiogenesis are able to block pathological neovascularization without harming the preexisting vasculature. Here we show that two such…”
Get full text

Short Pigment Epithelial-Derived Factor-Derived Peptide Inhibits Angiogenesis and Tumor Growth by MIROCHNIK, Yelena, AURORA, Arin, SCHULZE- HOEPFNER, Frank T, DEABES, Ahmed, SHIFRIN, Victor, BECKMANN, Richard, POLSKY, Charles, VOLPERT, Olga V

“…Purpose: Pigment epithelial-derived factor (PEDF) is a potent angiogenesis inhibitor with multiple other functions, some of which enhance tumor growth. Our…”
Get full text

Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer by Zhou, Xunian, Kurywchak, Paul, Wolf-Dennen, Kerri, Che, Sara P.Y., Sulakhe, Dinanath, D’Souza, Mark, Xie, Bingqing, Maltsev, Natalia, Gilliam, T. Conrad, Wu, Chia-Chin, McAndrews, Kathleen M., LeBleu, Valerie S., McConkey, David J., Volpert, Olga V., Pretzsch, Shanna M., Czerniak, Bogdan A., Dinney, Colin P., Kalluri, Raghu

“…Bladder cancer (BC), a heterogeneous disease characterized by high recurrence rates, is diagnosed and monitored by cystoscopy. Accurate clinical staging based…”
Get full text

Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer by FILLEUR, Stephanie, VOLZ, Karl, SHROFF, Emelyn H, VOLPERT, Olga V, NELIUS, Thomas, MIROCHNIK, Yelena, HANHUA HUANG, ZAICHUK, Tetiana A, AYNLERICH, Maria S, BECERRA, Sofia P, YAP, Ronald, VELICEASA, Dorina

“…Pigment epithelial-derived factor (PEDF), an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor…”
Get full text

Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma by Veliceasa, Dorina, Ivanovic, Marina, Hoepfner, Frank Thilo-Schulze, Thumbikat, Praveen, Volpert, Olga V, Smith, Norm D

“…Angiogenic switch in renal cell carcinoma (RCC) is attributed to the inactivation of the von Hippel-Lindau tumor suppressor, stabilization of hypoxia inducible…”
Get full text

Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma by Haltom, Amanda R, Hassen, Wafa E, Hensel, Janine, Kim, Jiha, Sugimoto, Hikaru, Li, Bingrui, McAndrews, Kathleen M, Conner, Meagan R, Kirtley, Michelle L, Luo, Xin, Xie, Bingqing, Volpert, Olga V, Olalekan, Susan, Maltsev, Natalia, Basu, Anindita, LeBleu, Valerie S, Kalluri, Raghu

“…Dysregulated Myc signaling is a key oncogenic pathway in glioblastoma multiforme (GBM). Yet, effective therapeutic targeting of Myc continues to be…”
Get full text

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis by English, Denis, Welch, Zachary, Kovala, A. Thomas, Harvey, Kevin, Volpert, Olga V., Brindley, David N., Garcia, Joe G. N.

“…ABSTRACT Recent studies have identified factors responsible for angiogenesis within developing tumors, but mediators of vessel formation at sites of trauma,…”
Get full text

Migration Inhibitory Factor Mediates Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol Kinase by Amin, M Asif, Volpert, Olga V, Woods, James M, Kumar, Pawan, Harlow, Lisa A, Koch, Alisa E

“…ABSTRACT—In this study, we investigated the effects of migration inhibitory factor (rhMIF) on angiogenesis-related signaling cascades and apoptosis in human…”
Get full text