Search Results - "VOLKIN, D. B"

Enhancement of DNA vaccine potency using conventional aluminum adjuvants by Ulmer, J.B., DeWitt, C.M., Chastain, M., Friedman, A., Donnelly, J.J., McClements, W.L., Caulfield, M.J., Bohannon, K.E., Volkin, D.B., Evans, R.K.

“…The immunogenicity and protective efficacy of DNA vaccines have been amply demonstrated in numerous animal models of infectious disease. However, the…”
Get full text

Evaluation of degradation pathways for plasmid DNA in pharmaceutical formulations via accelerated stability studies by Evans, R K, Xu, Z, Bohannon, K E, Wang, B, Bruner, M W, Volkin, D B

“…The stability of highly purified supercoiled plasmid DNA formulated in simple phosphate or Tris-buffered saline solutions has been characterized to establish…”
Get more information

Thermal destruction processes in proteins involving cystine residues by Volkin, D.B., Klibanov, A.M.

“…To ascertain the upper limit of protein thermostability and to evaluate the introduction of additional -S-S- bridges for the enhancement of protein…”
Get full text

Nature of the interaction of heparin with acidic fibroblast growth factor by Mach, Henryk, Volkin, David B, Burke, Carl J, Middaugh, C. Russell, Linhardt, Robert J, Fromm, Jonathan R, Loganathan, Duraikkannu, Mattsson, Lars

“…The binding of human acidic fibroblast growth factor (aFGF) to heparin has been analyzed by a variety of different approaches to better elucidate the nature of…”
Get full text

Formulation, stability, and delivery of live attenuated vaccines for human use by Burke, C J, Hsu, T A, Volkin, D B

“…The successful use of live attenuated viral and bacterial vaccines depends not only on the proper choice and delivery of the microorganisms, but also on…”
Get more information

Degradative covalent reactions important to protein stability by VOLKIN, D. B, MACH, H, MIDDAUGH, C. R

“…Commonly observed chemical modifications that occur in proteins during their in vitro purification, storage, and handling are discussed. Covalent modifications…”
Get full text

Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene by Casimiro, Danilo R, Chen, Ling, Fu, Tong-Ming, Evans, Robert K, Caulfield, Michael J, Davies, Mary-Ellen, Tang, Aimin, Chen, Minchun, Huang, Lingyi, Harris, Virginia, Freed, Daniel C, Wilson, Keith A, Dubey, Sheri, Zhu, De-Min, Nawrocki, Denise, Mach, Henryk, Troutman, Robert, Isopi, Lynne, Williams, Donna, Hurni, William, Xu, Zheng, Smith, Jeffrey G, Wang, Su, Liu, Xu, Guan, Liming, Long, Romnie, Trigona, Wendy, Heidecker, Gwendolyn J, Perry, Helen C, Persaud, Natasha, Toner, Timothy J, Su, Qin, Liang, Xiaoping, Youil, Rima, Chastain, Michael, Bett, Andrew J, Volkin, David B, Emini, Emilio A, Shiver, John W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Nature of the interaction of growth factors with suramin by Middaugh, C. Russell, Mach, Henryk, Burke, Carl J, Volkin, David B, Dabora, Jonathan M, Tsai, P. K, Bruner, Mark W, Ryan, James A, Marfia, Kimberly E

“…Suramin inhibits the binding of a variety of growth factors to their cell surface receptors. The direct interaction of suramin with acidic fibroblast growth…”
Get full text

Physical stabilization of acidic fibroblast growth factor by polyanions by Volkin, D B, Tsai, P K, Dabora, J M, Gress, J O, Burke, C J, Linhardt, R J, Middaugh, C R

“…Acidic fibroblast growth factor (aFGF) is markedly stabilized by heparin. Partially due to the heterogeneity of heparin preparations, the nature of the aFGF…”
Get more information

Formulation design of acidic fibroblast growth factor by TSAI, P. K, VOLKIN, D. B, DABORA, J. M, THOMPSON, K. C, BRUNER, M. W, GRESS, J. O, MATUSZEWSKA, B, KEOGAN, M, BONDI, J. V, MIDDAUGH, C. R

“…The design of an aqueous formulation for acidic fibroblast growth factor (aFGF) requires an understanding of the type of compounds that can either directly or…”
Get full text

Size and conformational stability of the hepatitis A virus used to prepare VAQTA, a highly purified inactivated vaccine by Volkin, D B, Burke, C J, Marfia, K E, Oswald, C B, Wolanski, B, Middaugh, C R

“…A variety of biophysical techniques have been employed to examine the size and conformational integrity of highly purified hepatitis A virus (HAV) in solution…”
Get more information

Effect of polyanions on the unfolding of acidic fibroblast growth factor by Burke, Carl J, Volkin, David B, Mach, Henryk, Middaugh, C. Russell

“…The urea-induced unfolding of acidic fibroblast growth factor (aFGF) in the presence and absence of various polyanions has been quantitatively examined by…”
Get full text

Partially structured self-associating states of acidic fibroblast growth factor by Mach, Henryk, Ryan, James A, Burke, Carl J, Volkin, David B, Middaugh, C. Russell

“…A combination of near- and far-UV circular dichroism, Fourier-transform infrared spectroscopy, tryptophan fluorescence, size-exclusion chromatography, and a…”
Get full text

Bacteriophage T7 RNA polymerase and its active-site mutants. Kinetic, spectroscopic and calorimetric characterization by Osumi-Davis, P A, Sreerama, N, Volkin, D B, Middaugh, C R, Woody, R W, Woody, A Y

“…It has been demonstrated that the amino acids Asp537, Asp812, Lys631, His811 and Tyr639 are involved in bacteriophage T7 RNA polymerase catalysis. In the…”
Get more information

Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene by Casimiro, Danilo R, Tang, Aimin, Chen, Ling, Fu, Tong-Ming, Evans, Robert K, Davies, Mary-Ellen, Freed, Daniel C, Hurni, William, Aste-Amezaga, Jose M, Guan, Liming, Long, Romnie, Huang, Lingyi, Harris, Virginia, Nawrocki, Denise K, Mach, Henryk, Troutman, Robert D, Isopi, Lynne A, Murthy, Krishna K, Rice, Karen, Wilson, Keith A, Volkin, David B, Emini, Emilio A, Shiver, John W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Analysis of vaccine stability by Volkin, D B, Burke, C J, Sanyal, G, Middaugh, C R

“…The complexity of vaccines creates a unique formulation challenge. Vaccines may consist of one or more types of antigenic component including live attenuated…”
Get more information

Complement subcomponent C1q secreted by cultured human monocytes has subunit structure identical with that of serum C1q by Tenner, A J, Volkin, D B

“…An enzyme-linked immunosorbent assay (e.l.i.s.a.) that is capable of quantifying C1q concentrations as low as 2 ng/ml and a sensitive haemolytic assay were…”
Get full text

Size exclusion HPLC method for the determination of acidic fibroblast growth factor in viscous formulations by Bruner, Mark W., Goldstein, Joel, Russell Middaugh, C., Brooks, Marvin A., Volkin, David B.

“…A size exclusion HPLC method has been developed to determine the protein concentration of pharmaceutical formulations of recombinant acidic fibroblast growth…”
Get full text

Deamidation of polyanion-stabilized acidic fibroblast growth factor by Volkin, D B, Verticelli, A M, Bruner, M W, Marfia, K E, Tsai, P K, Sardana, M K, Middaugh, C R

“…The deamidation of polyanion-stabilized acidic fibroblast growth factor (aFGF; FGF-1) can be induced by prolonged storage under accelerated conditions of…”
Get more information

Ultraviolet absorption spectroscopy by Mach, H, Volkin, D B, Burke, C J, Middaugh, C R

Get more information