Search Results - "VOLEK, JEFF S."
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Dietary fat: From foe to friend?
Published in Science (American Association for the Advancement of Science) (16-11-2018)“…For decades, dietary advice was based on the premise that high intakes of fat cause obesity, diabetes, heart disease, and possibly cancer. Recently, evidence…”
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Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health
Published in Journal of nutrition and metabolism (01-01-2018)“…Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic…”
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Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes
Published in Metabolism, clinical and experimental (01-04-2018)“…Low-carbohydrate diets have recently grown in popularity among endurance athletes, yet little is known about the long-term (>4wk) performance implications of…”
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Rethinking fat as a fuel for endurance exercise
Published in European journal of sport science (01-02-2015)“…A key element contributing to deteriorating exercise capacity during physically demanding sport appears to be reduced carbohydrate availability coupled with an…”
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Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial
Published in Frontiers in endocrinology (Lausanne) (05-06-2019)“…Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. We previously reported the effectiveness of a novel…”
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Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01-01-2015)“…Abstract The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity,…”
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Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
Published in Cardiovascular diabetology (01-05-2018)“…Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in…”
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Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study
Published in Diabetes therapy (01-04-2018)“…Introduction Carbohydrate restriction markedly improves glycemic control in patients with type 2 diabetes (T2D) but necessitates prompt medication changes…”
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Metabolic characteristics of keto-adapted ultra-endurance runners
Published in Metabolism, clinical and experimental (01-03-2016)“…Abstract Background Many successful ultra-endurance athletes have switched from a high-carbohydrate to a low-carbohydrate diet, but they have not previously…”
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Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based?
Published in Nutrients (22-09-2021)“…The last decade has seen nearly 20 papers reviewing the totality of the data on saturated fats and cardiovascular outcomes, which, altogether, have…”
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Effects of a ketogenic diet on motor function and motor unit number estimation in aged C57BL/6 mice
Published in The Journal of nutrition, health & aging (01-06-2024)“…Pathological, age-related loss of muscle function, commonly referred to as sarcopenia, contributes to loss of mobility, impaired independence, as well as…”
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Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes
Published in Cardiovascular diabetology (08-12-2020)“…We have previously reported that in patients with type 2 diabetes (T2D) consumption of a very low carbohydrate diet capable of inducing nutritional ketosis…”
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Self-reported menses physiology is positively modulated by a well-formulated, energy-controlled ketogenic diet vs. low fat diet in women of reproductive age with overweight/obesity
Published in PloS one (16-08-2024)“…Weight loss can positively alter female physiology; however, whether dietary carbohydrate- or fat- restriction confer unique effects is less studied. Precisely…”
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Effects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndrome
Published in PloS one (21-11-2014)“…Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids…”
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Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets
Published in Nutrients (22-09-2021)“…The decades-long dietary experiment embodied in the Dietary Guidelines for Americans (DGA) focused on limiting fat, especially saturated fat, and higher…”
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Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial
Published in PloS one (02-01-2024)“…Ketogenic diets may positively influence cancer through pleiotropic mechanisms, but only a few small and short-term studies have addressed feasibility and…”
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Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet
Published in Lipids (01-04-2009)“…We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that…”
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The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults
Published in Frontiers in neuroscience (30-09-2022)“…Background Ketogenic diets are a commonly used weight loss method, but little is known how variations in sodium content and ketones influence cognition and…”
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Comparison of Ketogenic Diets with and without Ketone Salts versus a Low-Fat Diet: Liver Fat Responses in Overweight Adults
Published in Nutrients (17-03-2021)“…Ketogenic diets (KDs) often contain high levels of saturated fat, which may increase liver fat, but the lower carbohydrate intake may have the opposite effect…”
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The Effects of Carbohydrate versus Fat Restriction on Lipid Profiles in Highly Trained, Recreational Distance Runners: A Randomized, Cross-Over Trial
Published in Nutrients (08-03-2022)“…A growing number of endurance athletes have considered switching from a traditional high-carbohydrate/low-fat (HCLF) to a low-carbohydrate/high-fat (LCHF)…”
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