Search Results - "VOLDERS, P. G. A"

Life-long tailoring of diagnosis and management of patients with idiopathic ventricular fibrillation—future perspectives in research by Blom, L. J., Volders, P. G. A., Wilde, A. A., Hassink, R. J.

“…The diagnosis and management of idiopathic ventricular fibrillation is challenging, as it requires extensive diagnostic testing and offers few curative options…”
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Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6 by Postema, P. G., Christiaans, I., Hofman, N., Alders, M., Koopmann, T. T., Bezzina, C. R., Loh, P., Zeppenfeld, K., Volders, P. G. A., Wilde, A. A. M.

“…In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial…”
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Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause? by Verheul, L M, Guglielmo, M, Groeneveld, S A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G F L, Alings, M, Evertz, R, Mulder, B A, Prakken, N H J, Balt, J C, Volders, P G A, Hirsch, A, Yap, S C, Postema, P G, Nijveldt, R, Velthuis, B K, Behr, E R, Wilde, A A M, Hassink, R J

“…Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF)…”
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Noninvasive reconstruction of cardiac electrical activity: update on current methods, applications and challenges by Cluitmans, M.J.M., Peeters, R.L.M., Westra, R.L., Volders, P.G.A.

“…Electrical activity at the level of the heart muscle can be noninvasively reconstructed from body-surface electrocardiograms (ECGs) and patient-specific…”
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The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update by Bosman, L. P., Verstraelen, T. E., van Lint, F. H. M., Cox, M. G. P. J., Groeneweg, J. A., Mast, T. P., van der Zwaag, P. A., Volders, P. G. A., Evertz, R., Wong, L., de Groot, N. M. S., Zeppenfeld, K., van der Heijden, J. F., van den Berg, M. P., Wilde, A. A. M., Asselbergs, F. W., Hauer, R. N. W., te Riele, A. S. J. M., van Tintelen, J. P.

“…Background Clinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and…”
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The role of the SCN5A‐encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders by Verstraelen, T. E., Bekke, R. M. A., Volders, P. G. A., Masclee, A. A. M., Kruimel, J. W.

“…Background Gastrointestinal functional and motility disorders, like irritable bowel syndrome (IBS), have a high prevalence in the Western population and cause…”
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Novel use of repolarization parameters in electrocardiographic imaging to uncover arrhythmogenic substrate by Blom, L.J., Groeneveld, S.A., Wulterkens, B.M., van Rees, B., Nguyen, U.C., Roudijk, R.W., Cluitmans, M., Volders, P.G.A., Hassink, R.J.

“…Measuring repolarization characteristics is challenging and has been reserved for experienced physicians. In electrocardiographic imaging (ECGI),…”
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Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula by Lau, Dennis H, Volders, Paul G A, Kohl, Peter, Prinzen, Frits W, Zaza, Antonio, Kääb, Stefan, Oto, Ali, Schotten, Ulrich

“…Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular medicine. This is in part due to the significant advances made in our…”
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Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes by Stengl, Milan, Volders, Paul G A, Thomsen, Morten B, Spätjens, Roel L H M G, Sipido, Karin R, Vos, Marc A

“…In guinea-pig ventricular myocytes, in which the deactivation of slowly activating delayed rectifier potassium current ( I Ks ) is slow, I Ks can be increased…”
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Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization by Thomsen, Morten B, Truin, Michiel, van Opstal, Jurren M, Beekman, Jet D M, Volders, Paul G A, Stengl, Milan, Vos, Marc A

“…Increased proarrhythmia in dogs with chronic AV block (AVB) has been explained by ventricular remodeling causing a decrease in repolarization reserve…”
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High-resolution repolarization changes preceding short-coupled ectopy in idiopathic ventricular fibrillation, and effects of quinidine by Stoks, J, Deissler, P, Ter Bekke, R M A, Volders, P G A

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3D target definition and initial results from the electroanatomic substrate-guided stereotactic ablative radiotherapy for refractory ventricular tachycardia (ELSTAR-VT) by Kaya, Y S, Stoks, J, Hazelaar, C, Elmpt, W, Gommers, S, Cluitmans, M J M, Dilling-Boer, D, De Ruysscher, D K M, Verhoeven, K, Volders, P G A, Ter Bekke, R M A

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Local areas of earlier repolarization cause epicardial repolarization heterogeneity in patients with apparently idiopathic ventricular fibrillation by Van Rees, B, Stoks, J, Nguyen, Y C, Ter Bekke, R M A, Mihl, C, Cluitmans, M, Volders, P G A

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Delayed ventricular conduction alters ventricular repolarization in patients with heart failure: an electrocardiographic imaging study by Nguyen, U, Stoks, J, Cluitmans, M J M, Strik, M, Van Rees, B, Meiburg, R, Mihl, C, Volders, P G A, Vernooy, K, Prinzen, F W

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An emerging role for DPP6: reciprocal regulation of INa-Ito and implications for arrhythmogenesis by Rossetti, A, Spatjens, R L H, Kammerer, S, Stoks, J, Firneburg, R, Seyen, S R, Helderman-Van Den Enden, A T J M, Wilde, A A M, Loeys, B L, Saenen, J, Heijman, J, Volders, P G A

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Temporal variability of electromechanical-window negativity in patients with inherited long-QT syndrome or drug-induced QT prolongation: relation to torsades de pointes by Deissler, P, Berkovitch, A, Rahm, A K, Sikking, M, Moersdorf, M, Sohns, C, Rieder, M, Nimani, S, Odening, K E, Sabbag, A, Volders, P G A, Ter Bekke, R M A

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How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? by Laverty, HG, Benson, C, Cartwright, EJ, Cross, MJ, Garland, C, Hammond, T, Holloway, C, McMahon, N, Milligan, J, Park, BK, Pirmohamed, M, Pollard, C, Radford, J, Roome, N, Sager, P, Singh, S, Suter, T, Suter, W, Trafford, A, Volders, PGA, Wallis, R, Weaver, R, York, M, Valentin, JP

“…Given that cardiovascular safety liabilities remain a major cause of drug attrition during preclinical and clinical development, adverse drug reactions, and…”
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End-diastolic myofiber stress and ejection strain increase with ventricular volume overload--Serial in-vivo analyses in dogs with complete atrioventricular block by Donker, D W, Volders, P G A, Arts, T, Bekkers, B C A M, Hofstra, L, Spätjens, R L H M G, Beekman, J D M, Borgers, M, Crijns, H J G M, Vos, M A

“…Myocardial stress and strain are considered primary mechanical stimuli for hypertrophic remodeling. Their values and significance in the intact beating heart…”
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P933Novel missense variant in DPP6 in familial ventricular fibrillation by Rossetti, A, Spatjens, R L H, Seyen, S R, Helderman-Van Den Enden, A T J, Wilde, A A M, Volders, P G A

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The role of the SCN 5A ‐encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders by Verstraelen, T. E., ter Bekke, R. M. A., Volders, P. G. A., Masclee, A. A. M., Kruimel, J. W.

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