Search Results - "VOGEL, Peter"

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease by Malireddi, R K Subbarao, Gurung, Prajwal, Kesavardhana, Sannula, Samir, Parimal, Burton, Amanda, Mummareddy, Harisankeerth, Vogel, Peter, Pelletier, Stephane, Burgula, Sandeepta, Kanneganti, Thirumala-Devi

“…RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and necroptosis. However, here we show a kinase activity-independent…”
Get full text

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis by Karki, Rajendra, Sundaram, Balamurugan, Sharma, Bhesh Raj, Lee, SangJoon, Malireddi, R.K. Subbarao, Nguyen, Lam Nhat, Christgen, Shelbi, Zheng, Min, Wang, Yaqiu, Samir, Parimal, Neale, Geoffrey, Vogel, Peter, Kanneganti, Thirumala-Devi

“…Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates…”
Get full text

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis by Sharma, Deepika, Malik, Ankit, Guy, Clifford S., Karki, Rajendra, Vogel, Peter, Kanneganti, Thirumala-Devi

“…Inflammatory bowel diseases (IBD) increase risk for colorectal cancer. Mutations in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary…”
Get full text

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis by Vande Walle, Lieselotte, Van Opdenbosch, Nina, Jacques, Peggy, Fossoul, Amelie, Verheugen, Eveline, Vogel, Peter, Beyaert, Rudi, Elewaut, Dirk, Kanneganti, Thirumala-Devi, van Loo, Geert, Lamkanfi, Mohamed

“…Pathogenesis of rheumatoid arthritis depends critically on the NLRP3 inflammasome/interleukin-1 signalling axis. Inflammasome-related rheumatoid arthritis…”
Get full text

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection by Man, Si Ming, Karki, Rajendra, Malireddi, R K Subbarao, Neale, Geoffrey, Vogel, Peter, Yamamoto, Masahiro, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…The mechanisms that control activation of the AIM2 inflammasome by cytosolic bacteria are unclear. Kanneganti and colleagues demonstrate that a pathway…”
Get full text

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer by Malik, Ankit, Sharma, Deepika, Malireddi, R.K. Subbarao, Guy, Clifford S., Chang, Ti-Cheng, Olsen, Scott R., Neale, Geoffrey, Vogel, Peter, Kanneganti, Thirumala-Devi

“…Fungi represent a significant proportion of the gut microbiota. Aberrant immune responses to fungi are frequently observed in inflammatory bowel diseases (IBD)…”
Get full text

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis by Chapman, Nicole M., Zeng, Hu, Nguyen, Thanh-Long M., Wang, Yanyan, Vogel, Peter, Dhungana, Yogesh, Liu, Xiaojing, Neale, Geoffrey, Locasale, Jason W., Chi, Hongbo

“…Regulatory T (T reg ) cells derived from the thymus (tT reg ) and periphery (pT reg ) have central and distinct functions in immunosuppression, but mechanisms…”
Get full text

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development by Kesavardhana, Sannula, Malireddi, R. K. Subbarao, Burton, Amanda R., Porter, Shaina N., Vogel, Peter, Pruett-Miller, Shondra M., Kanneganti, Thirumala-Devi

“…Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates host defense responses and development. ZBP1 activation triggers…”
Get full text

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation by Zaki, Mohammad Hasan, Vogel, Peter, Body-Malapel, Mathilde, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…Colorectal cancer is a leading cause of cancer-related deaths worldwide. Chronic inflammation is recognized as a predisposing factor for the development of…”
Get full text

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection by Karki, Rajendra, Man, Si Ming, Malireddi, R.K. Subbarao, Gurung, Prajwal, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…Invasive pulmonary aspergillosis is a leading cause of infection-associated mortality in immunocompromised individuals. Aspergillus fumigatus infection…”
Get full text

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis by Zaki, Md. Hasan, Boyd, Kelli L., Vogel, Peter, Kastan, Michael B., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…Decreased expression of the Nlrp3 protein is associated with susceptibility to Crohn's disease. However, the role of Nlrp3 in colitis has not been…”
Get full text

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins by Place, David E., Malireddi, R. K. Subbarao, Kim, Jieun, Vogel, Peter, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi

“…Chronic inflammation during many diseases is associated with bone loss. While interferons (IFNs) are often inhibitory to osteoclast formation, the complex role…”
Get full text

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation by Zhu, Qifan, Man, Si Ming, Gurung, Prajwal, Liu, Zhiping, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number…”
Get full text

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever by Kanneganti, Apurva, Malireddi, R K Subbarao, Saavedra, Pedro H V, Vande Walle, Lieselotte, Van Gorp, Hanne, Kambara, Hiroto, Tillman, Heather, Vogel, Peter, Luo, Hongbo R, Xavier, Ramnik J, Chi, Hongbo, Lamkanfi, Mohamed

“…Pyroptosis is an inflammasome-induced lytic cell death mode, the physiological role of which in chronic inflammatory diseases is unknown. Familial…”
Get full text

Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America by Kandeil, Ahmed, Patton, Christopher, Jones, Jeremy C., Jeevan, Trushar, Harrington, Walter N., Trifkovic, Sanja, Seiler, Jon P., Fabrizio, Thomas, Woodard, Karlie, Turner, Jasmine C., Crumpton, Jeri-Carol, Miller, Lance, Rubrum, Adam, DeBeauchamp, Jennifer, Russell, Charles J., Govorkova, Elena A., Vogel, Peter, Kim-Torchetti, Mia, Berhane, Yohannes, Stallknecht, David, Poulson, Rebecca, Kercher, Lisa, Webby, Richard J.

“…Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021 among wild birds and domestic poultry…”
Get full text

Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis by Kuriakose, Jeeba, Redecke, Vanessa, Guy, Cliff, Zhou, Jingran, Wu, Ruiqiong, Ippagunta, Sirish K, Tillman, Heather, Walker, Patrick D, Vogel, Peter, Häcker, Hans

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease with genetic and environmental contributions. Hallmarks of the disease are the appearance of…”
Get full text

Dietary modulation of the microbiome affects autoinflammatory disease by Lukens, John R., Gurung, Prajwal, Vogel, Peter, Johnson, Gordon R., Carter, Robert A., McGoldrick, Daniel J., Bandi, Srinivasa Rao, Calabrese, Christopher R., Walle, Lieselotte Vande, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…Pstpip2 -mutant mice fed a high-fat diet are protected against inflammatory bone disease and bone erosion; this protection is associated with reductions in…”
Get full text

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection by Zaki, Md. Hasan, Man, Si Ming, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi

“…The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective role in intestinal inflammation…”
Get full text

Galactosaminogalactan activates the inflammasome to provide host protection by Briard, Benoit, Fontaine, Thierry, Samir, Parimal, Place, David E., Muszkieta, Laetitia, Malireddi, R. K. Subbarao, Karki, Rajendra, Christgen, Shelbi, Bomme, Perrine, Vogel, Peter, Beau, Rémi, Mellado, Emilia, Ibrahim-Granet, Oumaima, Henrissat, Bernard, Kalathur, Ravi C., Robinson, Cam, Latgé, Jean-Paul, Kanneganti, Thirumala-Devi

“…Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular…”
Get full text

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer by Man, Si Ming, Zhu, Qifan, Zhu, Liqin, Liu, Zhiping, Karki, Rajendra, Malik, Ankit, Sharma, Deepika, Li, Liyuan, Malireddi, R.K. Subbarao, Gurung, Prajwal, Neale, Geoffrey, Olsen, Scott R., Carter, Robert A., McGoldrick, Daniel J., Wu, Gang, Finkelstein, David, Vogel, Peter, Gilbertson, Richard J., Kanneganti, Thirumala-Devi

“…Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal…”
Get full text