Search Results - "VOET, Arnout"

FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution by Huang, Gang, Voet, Arnout, Maglia, Giovanni

“…A high throughput single-molecule method for identifying peptides and sequencing proteins based on nanopores could reduce costs and increase speeds of…”
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Computational design of a self-assembling symmetrical β-propeller protein by Voet, Arnout R. D., Noguchi, Hiroki, Addy, Christine, Simoncini, David, Terada, Daiki, Unzai, Satoru, Park, Sam-Yong, Zhang, Kam Y. J., Tame, Jeremy R. H.

“…The modular structure of many protein families, such as β-propeller proteins, strongly implies that duplication played an important role in their evolution,…”
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The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide by Prekovic, Stefan, van Royen, Martin E, Voet, Arnout R D, Geverts, Bart, Houtman, Rene, Melchers, Diana, Zhang, Kam Y J, Van den Broeck, Thomas, Smeets, Elien, Spans, Lien, Houtsmuller, Adriaan B, Joniau, Steven, Claessens, Frank, Helsen, Christine

“…Treatment-induced mutations in the ligand-binding domain of the androgen receptor (AR) are known to change antagonists into agonists. Recently, the F877L…”
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Small Differences in SUC Gene Sequences Impact Saccharomyces cerevisiae Invertase Activity and Specificity toward Fructans with Different Chain Lengths by Laurent, Jitka, Aerts, Anouk, Gordon, Jonathan, Gupta, Purvi, Voet, Arnout R. D, Verstrepen, Kevin J, Courtin, Christophe M

“…Saccharomyces cerevisiae (S. cerevisiae)invertase is encoded by a family of closely related SUC genes. To identify and understand the molecular basis for…”
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Hybrid assemblies of a symmetric designer protein and polyoxometalates with matching symmetry by Vandebroek, Laurens, Noguchi, Hiroki, Kamata, Kenichi, Tame, Jeremy R H, Van Meervelt, Luc, Parac-Vogt, Tatjana N, Voet, Arnout R D

“…Novel bioinorganic hybrid materials based on proteins and inorganic clusters have enormous potential for the development of hybrid catalysts that…”
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Biomineralization of a Cadmium Chloride Nanocrystal by a Designed Symmetrical Protein by Voet, Arnout R. D., Noguchi, Hiroki, Addy, Christine, Zhang, Kam Y. J., Tame, Jeremy R. H.

“…We have engineered a metal‐binding site into the novel artificial β‐propeller protein Pizza. This new Pizza variant carries two nearly identical domains per…”
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Structure and stability of the designer protein WRAP-T and its permutants by Mylemans, Bram, Lee, Xiao Yin, Laier, Ina, Helsen, Christine, Voet, Arnout R. D.

“…β -Propeller proteins are common natural disc-like pseudo-symmetric proteins that contain multiple repeats (‘blades’) each consisting of a 4-stranded…”
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Hierarchical Self-Assembly of a Supramolecular Protein-Metal Cage Encapsulating a Polyoxometalate Guest by Vandebroek, Laurens, Noguchi, Hiroki, Anyushin, Alexander, Van Meervelt, Luc, Voet, Arnout R. D, Parac-Vogt, Tatjana N

“…Hierarchical self-assembly of hybrid bioinorganic structures is a challenging task which requires specific and tailored interactions. Here we report a…”
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Shape and Size Complementarity-Induced Formation of Supramolecular Protein Assemblies with Metal-Oxo Clusters by Vandebroek, Laurens, Noguchi, Hiroki, Kamata, Kenichi, Tame, Jeremy R. H, Van Meervelt, Luc, Parac-Vogt, Tatjana N, Voet, Arnout R. D

“…The controlled formation of protein supramolecular assemblies is challenging, but it could provide an important route for the development of hybrid…”
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Structural plasticity of a designer protein sheds light on β‐propeller protein evolution by Mylemans, Bram, Laier, Ina, Kamata, Kenichi, Akashi, Satoko, Noguchi, Hiroki, Tame, Jeremy R. H., Voet, Arnout R. D.

“…β‐propeller proteins are common in nature, where they are observed to adopt 4‐ to 10‐fold internal rotational pseudo‐symmetry. This size diversity can be…”
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Artificial β-propeller protein-based hydrolases by Clarke, David E, Noguchi, Hiroki, Gryspeerdt, Jean-Louis A G, De Feyter, Steven, Voet, Arnout R D

“…We developed an artificial hydrolase based on the symmetrical Pizza6 β-propeller protein for the metal-free hydrolysis of 4-nitrophenyl acetate and butyrate…”
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Influence of circular permutations on the structure and stability of a six‐fold circular symmetric designer protein by Mylemans, Bram, Noguchi, Hiroki, Deridder, Els, Lescrinier, Eveline, Tame, Jeremy R. H., Voet, Arnout R. D.

“…The β‐propeller fold is adopted by a sequentially diverse family of repeat proteins with apparent rotational symmetry. While the structure is mostly stabilized…”
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A widely applicable and cost-effective method for specific RNA–protein complex isolation by Balzarini, Sam, Van Ende, Roosje, Voet, Arnout, Geuten, Koen

“…Although methodological advances have been made over the past years, a widely applicable, easily scalable and cost-effective procedure that can be routinely…”
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The Taming of the Screw: the natural and artificial development of β-propeller proteins by Mylemans, Bram, Voet, Arnout RD, Tame, Jeremy RH

“…Many proteins are found to possess repeated structural elements, which hint at ancient evolutionary origins and ongoing evolutionary processes. β-propeller…”
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Protein-templated synthesis of metal-based nanomaterials by Voet, Arnout RD, Tame, Jeremy RH

“…Graphical abstract…”
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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes by Neggers, Jasper Edgar, Kwanten, Bert, Dierckx, Tim, Noguchi, Hiroki, Voet, Arnout, Bral, Lotte, Minner, Kristien, Massant, Bob, Kint, Nicolas, Delforge, Michel, Vercruysse, Thomas, Baloglu, Erkan, Senapedis, William, Jacquemyn, Maarten, Daelemans, Dirk

“…Unraveling the mechanism of action and molecular target of small molecules remains a major challenge in drug discovery. While many cancer drugs target genetic…”
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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors by Gilles, Philippe, Kashyap, Rudra S., Freitas, Maria João, Ceusters, Sam, Van Asch, Koen, Janssens, Anke, De Jonghe, Steven, Persoons, Leentje, Cobbaut, Mathias, Daelemans, Dirk, Van Lint, Johan, Voet, Arnout R.D., De Borggraeve, Wim M.

“…The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been repeatedly reported. Therefore, the search for novel PKD inhibitors and…”
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Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres by Verhaegen, Yenthel, Liu, Libao, Nguyen, Tien T., Loy, Tom Van, Schols, Dominique, Voet, Arnout R.D., Dehaen, Wim, De Jonghe, Steven

“…[Display omitted] •CCR8 antagonists are promising anti-inflammatory and antitumoral drugs.•Various isosteres of known naphthalene sulfonamide CCR8 antagonists…”
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Androgen receptor antagonists for prostate cancer therapy by Helsen, Christine, Van den Broeck, Thomas, Voet, Arnout, Prekovic, Stefan, Van Poppel, Hendrik, Joniau, Steven, Claessens, Frank

“…Androgen deprivation is the mainstay therapy for metastatic prostate cancer (PCa). Another way of suppressing androgen receptor (AR) signaling is via AR…”
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Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4 by Voet, Arnout R. D., Kumar, Ashutosh, Berenger, Francois, Zhang, Kam Y. J.

“…The SAMPL challenges provide an ideal opportunity for unbiased evaluation and comparison of different approaches used in computational drug design. During the…”
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