Search Results - "VODICKOVA, LUDMILA"
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Frequencies of chromosomal aberrations and related biochemical parameters in welders
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01-08-2024)“…Stainless steel welders are exposed to heavy filler metals. We evaluated the concentration of these metals in whole blood and urine, and the relevant…”
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Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies
Published in Frontiers in oncology (24-08-2023)Get full text
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Distant Metastasis in Colorectal Cancer Patients-Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review
Published in International journal of molecular sciences (24-07-2020)“…Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half of patients will develop distant metastasis after CRC resection, usually…”
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DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers
Published in International journal of molecular sciences (03-08-2020)“…The phenotypic effects of single nucleotide polymorphisms (SNPs) in the development of sporadic solid cancers are still scarce. The aim of this review was to…”
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Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
Published in Scientific reports (16-02-2022)“…A large proportion of colorectal carcinomas (CRC) evolve from colorectal adenomas. However, not all individuals with colonic adenomas have a risk of CRC…”
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Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients
Published in International journal of molecular sciences (02-04-2020)“…Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is…”
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Author Correction: Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
Published in Scientific reports (04-04-2022)Get full text
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8
The dynamics of telomere length in primary and metastatic colorectal cancer lesions
Published in Scientific reports (05-06-2023)“…Telomeric sequences, the structures comprised of hexanucleotide repeats and associated proteins, play a pivotal role in chromosome end protection and…”
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Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival
Published in PloS one (15-05-2019)“…Mucins and their glycosylation have been suggested to play an important role in colorectal carcinogenesis. We examined potentially functional genetic variants…”
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Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions
Published in International journal of molecular sciences (11-07-2022)“…A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this…”
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The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
Published in Critical reviews in oncology/hematology (01-06-2023)“…Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so…”
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TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer
Published in Frontiers in oncology (02-08-2022)“…Telomeres are complex protective structures located at the ends of linear eukaryotic chromosomes. Their purpose is to prevent genomic instability. Research…”
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Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients
Published in International journal of molecular sciences (20-05-2022)“…Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation,…”
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14
Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer
Published in PloS one (06-02-2018)“…Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through…”
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The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations
Published in Nutrients (29-06-2022)“…Background: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and…”
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Author Correction: Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
Published in Scientific reports (21-10-2022)Get full text
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17
Variation within 3'-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Published in Clinical cancer research (01-11-2013)“…Colorectal cancer is routinely treated with a 5-fluorouracil (5-FU)-based chemotherapy. 5-FU incorporates into DNA, and the base excision repair (BER) pathway…”
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Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma
Published in Leukemia (01-07-2019)Get full text
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Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer
Published in Frontiers in oncology (27-04-2023)“…Despite distant metastases being the critical factor affecting patients' survival, they remain poorly understood. Our study thus aimed to molecularly…”
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Association between taste receptor (TAS) genes and the perception of wine characteristics
Published in Scientific reports (23-08-2017)“…Several studies have suggested a possible relationship between polymorphic variants of the taste receptors genes and the acceptance, liking and intake of food…”
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