Search Results - "VLEMINCKX, Kris"

CRISPR/Cas9 disease models in zebrafish and Xenopus: The genetic renaissance of fish and frogs by Naert, Thomas, Vleminckx, Kris

“…[Display omitted] The speed by which clinical genomics is currently identifying novel potentially pathogenic variants is outperforming the speed by which these…”
Get full text

TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models by Naert, Thomas, Van Nieuwenhuysen, Tom, Vleminckx, Kris

“…The targeted nuclease revolution (TALENs, CRISPR/Cas9) now allows Xenopus researchers to rapidly generate custom on‐demand genetic knockout models. These novel…”
Get full text

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis by Naert, Thomas, Dimitrakopoulou, Dionysia, Tulkens, Dieter, Demuynck, Suzan, Carron, Marjolein, Noelanders, Rivka, Eeckhout, Liza, Van Isterdael, Gert, Deforce, Dieter, Vanhove, Christian, Van Dorpe, Jo, Creytens, David, Vleminckx, Kris

“…Alterations of the retinoblastoma and/or the p53 signaling network are associated with specific cancers such as high-grade astrocytoma/glioblastoma, small-cell…”
Get full text

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos by Naert, Thomas, Tulkens, Dieter, Edwards, Nicole A., Carron, Marjolein, Shaidani, Nikko-Ideen, Wlizla, Marcin, Boel, Annekatrien, Demuynck, Suzan, Horb, Marko E., Coucke, Paul, Willaert, Andy, Zorn, Aaron M., Vleminckx, Kris

“…CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F 0 animals too often demonstrate variable…”
Get full text

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians by Carron, Marjolein, Sachslehner, Attila Placido, Cicekdal, Munevver Burcu, Bruggeman, Inge, Demuynck, Suzan, Golabi, Bahar, De Baere, Elfride, Declercq, Wim, Tschachler, Erwin, Vleminckx, Kris, Eckhart, Leopold

“…Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of…”
Get full text

ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia by Haas, Maximilian, Gómez Vázquez, José Luis, Sun, Dingyuan Iris, Tran, Hong Thi, Brislinger, Magdalena, Tasca, Alexia, Shomroni, Orr, Vleminckx, Kris, Walentek, Peter

“…Mucociliary epithelia provide a first line of defense against pathogens. Impaired regeneration and remodeling of mucociliary epithelia are associated with…”
Get full text

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis by Naert, Thomas, Colpaert, Robin, Van Nieuwenhuysen, Tom, Dimitrakopoulou, Dionysia, Leoen, Jannick, Haustraete, Jurgen, Boel, Annekatrien, Steyaert, Wouter, Lepez, Trees, Deforce, Dieter, Willaert, Andy, Creytens, David, Vleminckx, Kris

“…Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 ( RB1 ) gene is the initiating genetic lesion. Although…”
Get full text

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development by Ceroni, Fabiola, Cicekdal, Munevver B., Holt, Richard, Sorokina, Elena, Chassaing, Nicolas, Clokie, Samuel, Naert, Thomas, Talbot, Lidiya V., Muheisen, Sanaa, Bax, Dorine A., Kesim, Yesim, Kivuva, Emma C., Vincent-Delorme, Catherine, Lienkamp, Soeren S., Plaisancié, Julie, De Baere, Elfride, Calvas, Patrick, Vleminckx, Kris, Semina, Elena V., Ragge, Nicola K.

“…Anophthalmia, microphthalmia and coloboma (AMC) comprise a spectrum of developmental eye disorders, accounting for approximately 20% of childhood visual…”
Get full text

An atlas of Wnt activity during embryogenesis in Xenopus tropicalis by Borday, Caroline, Parain, Karine, Thi Tran, Hong, Vleminckx, Kris, Perron, Muriel, Monsoro-Burq, Anne H

“…Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt…”
Get full text

Xenopus tropicalis : Joining the Armada in the Fight Against Blood Cancer by Dimitrakopoulou, Dionysia, Tulkens, Dieter, Van Vlierberghe, Pieter, Vleminckx, Kris

“…Aquatic vertebrate organisms such as zebrafish have been used for over a decade to model different types of human cancer, including hematologic malignancies…”
Get full text

Hes4 Controls Proliferative Properties of Neural Stem Cells During Retinal Ontogenesis by El Yakoubi, Warif, Borday, Caroline, Hamdache, Johanna, Parain, Karine, Tran, Hong Thi, Vleminckx, Kris, Perron, Muriel, Locker, Morgane

“…The retina of fish and amphibian contains genuine neural stem cells located at the most peripheral edge of the ciliary marginal zone (CMZ). However, their…”
Get full text

Wnt/β-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo by Tran, Hong Thi, Sekkali, Belaïd, Van Imschoot, Griet, Janssens, Sylvie, Vleminckx, Kris

“…The formation of primitive (embryonic) blood in vertebrates is mediated by spatio-temporally restricted signaling between different tissue layers. In Xenopus,…”
Get full text

Corrigendum: Xenopus tropicalis : Joining the Armada in the Fight Against Blood Cancer by Dimitrakopoulou, Dionysia, Tulkens, Dieter, Van Vlierberghe, Pieter, Vleminckx, Kris

“…[This corrects the article DOI: 10.3389/fphys.2019.00048.]…”
Get full text

Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation by Tran, Hong Thi, Fransen, Mathias, Dimitrakopoulou, Dionysia, Van Imschoot, Griet, Willemarck, Nicolas, Vleminckx, Kris

“…Caspases constitute a family of cysteine proteases centrally involved in programmed cell death, which is an integral part of normal embryonic and fetal…”
Get full text

A Molecular atlas of Xenopus respiratory system development by Rankin, Scott A., Thi Tran, Hong, Wlizla, Marcin, Mancini, Pamela, Shifley, Emily T., Bloor, Sean D., Han, Lu, Vleminckx, Kris, Wert, Susan E., Zorn, Aaron M.

“…Background: Respiratory system development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus…”
Get full text

Cadherins and tissue formation: integrating adhesion and signaling by Vleminckx, Kris, Kemler, Rolf

“…Cadherins and other cell–substrate and cell–cell adhesion molecules play an essential role during development. Through their cytoplasmic interaction with the…”
Get full text

The role of Wnt in cell signaling and cell adhesion during early vertebrate development by Sylvie, Janssens, Ellen, Crabbe, Kris, Vleminckx

“…During embryonic development, a group of dividing blastomeres is ultimately shaped into a structured, functional organism. To achieve this goal, individual…”
Get full text

Author Correction: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6 by Szenker-Ravi, Emmanuelle, Altunoglu, Umut, Leushacke, Marc, Bosso-Lefèvre, Célia, Khatoo, Muznah, Thi Tran, Hong, Naert, Thomas, Noelanders, Rivka, Hajamohideen, Amin, Beneteau, Claire, de Sousa, Sergio B., Karaman, Birsen, Latypova, Xenia, Başaran, Seher, Yücel, Esra Börklü, Tan, Thong Teck, Vlaminck, Lena, Nayak, Shalini S., Shukla, Anju, Girisha, Katta Mohan, Le Caignec, Cédric, Soshnikova, Natalia, Uyguner, Zehra Oya, Vleminckx, Kris, Barker, Nick, Kayserili, Hülya, Reversade, Bruno

“…In this Letter, the surname of author Lena Vlaminck was misspelled ‘Vlaeminck’. In addition, author Kris Vleminckx should have been associated with affiliation…”
Get full text

You'd better catch that Wnt: Primitive hematopoiesis requires canonical Wnt signaling by Tran, Hong Thi, Vleminckx, Kris

“…Comment on: Tran HT, et al. Proc Natl Acad Sci USA 2010; 107:16160-5…”
Get full text

Canonical Wnt Signaling Controls Proliferation of Retinal Stem/Progenitor Cells in Postembryonic Xenopus Eyes by Denayer, Tinneke, Locker, Morgane, Borday, Caroline, Deroo, Tom, Janssens, Sylvie, Hecht, Andreas, van Roy, Frans, Perron, Muriel, Vleminckx, Kris

“…Vertebrate retinal stem cells, which reside quiescently within the ciliary margin, may offer a possibility for treatment of degenerative retinopathies. The…”
Get full text