Search Results - "VLAHOV, Lontcho R"

Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease by SHILLINGFORD, Jonathan M, LEAMON, Christopher P, VLAHOV, Lontcho R, WEIMBS, Thomas

“…Activation of the mammalian target of rapamycin (mTOR) signaling pathway is aberrant in autosomal-dominant polycystic kidney disease (ADPKD). The mTOR…”
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Targeting Folate Receptors to Treat Invasive Urinary Bladder Cancer by DHAWAN, Deepika, RAMOS-VARA, Jose A, REDDY, Joseph A, KOCH, Michael, MURPHY, Linda, FOUREZ, Lindsey M, STEWART, Jane C, KNAPP, Deborah W, NAUGHTON, James F, LIANG CHENG, LOW, Philip S, ROTHENBUHLER, Ryan, LEAMON, Christopher P, PARKER, Nikki, KLEIN, Patrick J, VLAHOV, Lontcho R

“…Folate receptors (FR) may be of use for targeted delivery of cytotoxic drugs in invasive urothelial carcinoma (iUC), for which improved therapy is needed. FR…”
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Comparative preclinical activity of the folate‐targeted Vinca alkaloid conjugates EC140 and EC145 by Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Westrick, Elaine, Parker, Nikki, Nicoson, Jeffrey S., Vetzel, Marilynn

“…EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome‐cleavable acyl hydrazone bond…”
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