Search Results - "VLAHOS, Chris J"

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes by WAY, Kerrie J, ISSHIKI, Keiji, KING, George L, SUZUMA, Kiyoshi, YOKOTA, Tamotsu, ZVAGELSKY, Dmitriy, SCHOEN, Frederick J, SANDUSKY, George E, PECHOUS, Penelope A, VLAHOS, Chris J, WAKASAKI, Hisao

“…Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes Kerrie J. Way 1 ,…”
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Kinases as therapeutic targets for heart failure by Vlahos, Chris J, McDowell, Susan A, Clerk, Angela

“…Cardiac cells respond to external stimuli by activating signal-transduction cascades involving protein and lipid kinases. These enzymes are attractive…”
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An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model by Duan, Wei, Aguinaldo Datiles, Ana M.K., Leung, Bernard P., Vlahos, Chris J., Wong, W.S. Fred

“…Phosphoinositide 3-kinase (PI3K) exhibits broad functional effects in immune cells. We investigated the role of PI3K in allergic airway inflammation using…”
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Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity by Blazer-Yost, Bonnie L, Esterman, Michail A, Vlahos, Chris J

“…AlphaENaC-EGFP (enhanced green fluorescent protein-tagged alpha-subunit of the epithelial Na(+) channel) stably transfected clonal lines derived from the A6…”
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A cell-based immunocytochemical assay for monitoring kinase signaling pathways and drug efficacy by Chen, Huaxian, Kovar, Joy, Sissons, Sean, Cox, Karen, Matter, William, Chadwell, Fred, Luan, Peng, Vlahos, Chris J., Schutz-Geschwender, Amy, Olive, D. Michael

“…Protein kinases play important roles in many disease processes and are primary targets for drug development. Because cellular phosphorylation cascades are…”
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Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA by Wang, Xushan, Mader, Mary M., Toth, John E., Yu, Xiaohong, Jin, Najia, Campbell, Robert M., Smallwood, Jeffrey K., Christe, Michael E., Chatterjee, Arindam, Goodson, Theodore, Vlahos, Chris J., Matter, William F., Bloem, Laura J.

“…Mixed lineage kinase 7 (MLK7) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the pro-apoptotic signaling pathways p38 and JNK. A…”
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Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling by Zeng, Wei, Matter, William F, Yan, S Betty, Um, Suzane L, Vlahos, Chris J, Liu, Ling

“…OBJECTIVE:To explore whether the improvement in organ function and the vasoactive effect observed in the clinical studies of drotrecogin alfa (activated)…”
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Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption by Blazer-Yost, B L, Păunescu, T G, Helman, S I, Lee, K D, Vlahos, C J

“…Aldosterone, a steroid hormone, regulates renal Na+ reabsorption and, therefore, plays an important role in the maintenance of salt and water balance. In a…”
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Phosphatidylinositol 3-kinase activation is required for insulin-stimulated sodium transport in A6 cells by Record, R D, Froelich, L L, Vlahos, C J, Blazer-Yost, B L

“…Insulin stimulates amiloride-sensitive sodium transport in models of the distal nephron. Here we demonstrate that, in the A6 cell line, this action is mediated…”
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Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue by CHOU, Eva, SUZUMA, Izumi, KING, George L, WAY, Kerrie J, OPLAND, Darren, CLERMONT, Allen C, NARUSE, Keiko, SUZUMA, Kiyoshi, BOWLING, Nancy L, VLAHOS, Chris J, AIELLO, Lloyd Paul

“…Inadequate angiogenic response to ischemia in the myocardium of diabetic patients could result in poor collateral formation. Yet, excessive neovascularization…”
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Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs by Norman, Bryan H, Shih, Chuan, Toth, John E, Ray, James E, Dodge, Jeffrey A, Johnson, Doug W, Rutherford, Pamela G, Schultz, Richard M, Worzalla, John F, Vlahos, Chris J

“…Wortmannin, a fungal metabolite, was identified as a potent inhibitor (IC50 = 4.2 nM) of phosphatidylinositol 3-kinase (PI 3-kinase). Due to the importance of…”
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Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis by Arbiser, Jack L., Kau, Tweeny, Konar, Martha, Narra, Krishna, Ramchandran, Ramani, Summers, Scott A., Vlahos, Chris J., Ye, Keqiang, Perry, Betsy N., Matter, William, Fischl, Anthony, Cook, James, Silver, Pamela A., Bain, Jenny, Cohen, Philip, Whitmire, David, Furness, Scott, Govindarajan, Baskaran, Bowen, J. Phillip

“…Phosphatidylinositol-3-kinase (PI3K), and its downstream effector Akt, or protein kinase Bα (PKBα), play a major regulatory role in control of apoptosis,…”
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Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation by Rekhter, Mark, Staschke, Kirk, Estridge, Thomas, Rutherford, Pamela, Jackson, Nancy, Gifford-Moore, Donetta, Foxworthy, Patricia, Reidy, Charles, Huang, Xiao-di, Kalbfleisch, Michael, Hui, Kwan, Kuo, Ming-Shang, Gilmour, Raymond, Vlahos, Chris J.

“…Inflammation is critically involved in atherogenesis. Signaling from innate immunity receptors TLR2 and 4, IL-1 and IL-18 is mediated by MyD88 and further by…”
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Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart by BOWLING, N, WALSH, R. A, SABBAH, H. N, MIZRAHI, J. L, GROMO, G, KING, G. L, VLAHOS, C. J, GUOJIE SONG, ESTRIDGE, T, SANDUSKY, G. E, FOUTS, R. L, MINTZE, K, PICKARD, T, RODEN, R, BRISTOW, M. R

“…Increased expression of Ca2+-sensitive protein kinase C (PKC) isoforms may be important markers of heart failure. Our aim was to determine the relative…”
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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase by POWIS, G, BONJOUKLIAN, R, VLAHOS, C. J, BERGGREN, M. M, GALLEGOS, A, ABRAHAM, R, ASHENDEL, C, ZALKOW, L, MATTER, W. F, DODGE, J, GRINDEY, G

“…Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of its analogues have been shown to…”
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Synthesis and in Vitro Evaluation of New Wortmannin Esters:  Potent Inhibitors of Phosphatidylinositol 3-Kinase by Creemer, Lawrence C, Kirst, Herbert A, Vlahos, Chris J, Schultz, Richard M

“…New C-11 esters of the fermentation product wortmannin have been synthesized, with some of them further derivatized at C-17. The new esters show greater…”
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Role of PRL-3, a Human Muscle-Specific Tyrosine Phosphatase, in Angiotensin-II Signaling by Matter, William F., Estridge, Thomas, Zhang, Chen, Belagaje, Rama, Stancato, Louis, Dixon, Jeff, Johnson, Brian, Bloem, Laura, Pickard, Todd, Donaghue, Mary, Acton, Susan, Jeyaseelan, Raju, Kadambi, Vivek, Vlahos, Chris J.

“…Action of protein kinases and phosphatases contributes to myocardial hypertrophy. PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from…”
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Calmodulin Activates Phosphatidylinositol 3-Kinase by Joyal, John L., Burks, Deborah J., Pons, Sebastian, Matter, William F., Vlahos, Chris J., White, Morris F., Sacks, David B.

“…Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector…”
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Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase by Giner, José-Luis, Kehbein, Karen A, Cook, James A., Smith, Michele C., Vlahos, Chris J., Badwey, John A.

“…Fluorescent analogs were synthesized of the potent PI 3-kinase inhibitors, wortmannin and demethoxyviridin. The esterification of 11-deacetylwortmannin,…”
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Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes by McDowell, Susan A, McCall, Eileen, Matter, William F, Estridge, Thomas B, Vlahos, Chris J

“…The phosphoinositide 3-kinase (PI3K) inhibitor LY-294002 decreased steady-state contraction in neonatal rat ventricular myocytes (NRVM). To determine whether…”
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