Search Results - "VLAHAKIS, NICHOLAS E"

Integrin α9β1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase by Gupta, Shiv K, Vlahakis, Nicholas E

“…Integrins are important mediators of cell adhesion and migration, which in turn are essential for diverse biological functions, including wound healing and…”
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Integrin α9β1 Directly Binds to Vascular Endothelial Growth Factor (VEGF)-A and Contributes to VEGF-A-induced Angiogenesis by Vlahakis, Nicholas E., Young, Bradford A., Atakilit, Amha, Hawkridge, Anne E., Issaka, Rachel B., Boudreau, Nancy, Sheppard, Dean

“…Vascular endothelial growth factor A (VEGF-A) is a potent inducer of angiogenesis. We now show that VEGF-A-induced adhesion and migration of human endothelial…”
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Heparin-Induced Thrombocytopenia in Medical Surgical Critical Illness by Warkentin, Theodore E., MD, Sheppard, Jo-Ann I., BSc, Heels-Ansdell, Diane, MSc, Marshall, John C., MD, McIntyre, Lauralyn, MD, Rocha, Marcelo G., MD, Mehta, Sangeeta, MD, Davies, Andrew R., MD, Bersten, Andrew D., MD, Crozier, Tim M., MD, Ernest, David, MD, Vlahakis, Nicholas E., MD, FCCP, Hall, Richard I., MD, FCCP, Wood, Gordon G., MD, Poirier, Germain, MD, Crowther, Mark A., MD, Cook, Deborah J., MD

“…Background In a recent multicenter randomized trial comparing unfractionated heparin (UFH) with low-molecular-weight heparin (dalteparin) for…”
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Fetal outcomes of critically ill pregnant women admitted to the intensive care unit for nonobstetric causes by Cartin-Ceba, Rodrigo, Gajic, Ognjen, Iyer, Vivek N, Vlahakis, Nicholas E

“…INTRODUCTION:The outcome of the fetus in critically ill mothers has been briefly reported as a part of descriptive studies focusing on maternal risk factors…”
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B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema by Rana, Rimki, Vlahakis, Nicholas E, Daniels, Craig E, Jaffe, Allan S, Klee, George G, Hubmayr, Rolf D, Gajic, Ognjen

“…OBJECTIVE:The role of plasma B-type natriuretic peptide (BNP) in critically ill patients with acute pulmonary edema is controversial. We postulated that a low…”
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Role of Deformation-induced Lipid Trafficking in the Prevention of Plasma Membrane Stress Failure by Vlahakis, Nicholas E, Schroeder, Mark A, Pagano, Richard E, Hubmayr, Rolf D

“…Cells experience plasma membrane stress failure when the matrix to which they adhere undergoes large deformations. In the lung, such a mechanism might explain…”
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Dalteparin versus Unfractionated Heparin in Critically Ill Patients by Cook, Deborah, Meade, Maureen, Guyatt, Gordon, Walter, Stephen, Heels-Ansdell, Diane, Warkentin, Theodore E, Zytaruk, Nicole, Crowther, Mark, Geerts, William, Cooper, D Jamie, Vallance, Shirley, Qushmaq, Ismael, Rocha, Marcelo, Berwanger, Otavio, Vlahakis, Nicholas E

“…In this trial, patients admitted to ICUs were assigned to receive dalteparin, a low-molecular-weight heparin, or unfractionated heparin for thromboprophylaxis…”
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Sirolimus-associated diffuse alveolar hemorrhage by Vlahakis, Nicholas E, Rickman, Otis B, Morgenthaler, Timothy

“…Sirolimus is an immunosuppressive medication used in transplant recipients. To our knowledge, we describe the third reported case of alveolar hemorrhage in…”
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Invited review: plasma membrane stress failure in alveolar epithelial cells by Vlahakis, N E, Hubmayr, R D

“…In this review, we examine the hypothesis that plasma membrane stress failure is a central event in the pathophysiology of injury from alveolar overdistension…”
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The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments by Das, Soumen, Singh, Sanjay, Dowding, Janet M, Oommen, Saji, Kumar, Amit, Sayle, Thi X.T, Saraf, Shashank, Patra, Chitta R, Vlahakis, Nicholas E, Sayle, Dean C, Self, William T, Seal, Sudipta

“…Abstract Angiogenesis is the formation of new blood vessels from existing blood vessels and is critical for many physiological and pathophysiological…”
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Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin α9β1: IDENTIFICATION OF A SPECIFIC α9β1 BINDING SITE by Oommen, Saji, Gupta, Shiv K, Vlahakis, Nicholas E

“…Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a number of diverse extracellular ligands. We have shown previously…”
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Deformation-induced lipid trafficking in alveolar epithelial cells by Vlahakis, N E, Schroeder, M A, Pagano, R E, Hubmayr, R D

“…Mechanical ventilation with a high tidal volume results in lung injury that is characterized by blebbing and breaks both between and through alveolar…”
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Cellular Stress Failure in Ventilator-injured Lungs by Vlahakis, Nicholas E, Hubmayr, Rolf D

“…The clinical and experimental literature has unequivocally established that mechanical ventilation with large tidal volumes is injurious to the lung. However,…”
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Effects of an allosteric hemoglobin affinity modulator on arterial blood gases and cardiopulmonary responses during normoxic and hypoxic low-intensity exercise by Stewart, Glenn M, Chase, Steven, Cross, Troy J, Wheatley-Guy, Courtney M, Joyner, Michael J, Curry, Timothy, Lehrer-Graiwer, Josh, Dufu, Kobina, Vlahakis, Nicholas E, Johnson, Bruce D

“…Numerous pathophysiological conditions induce hypoxemia-related cardiopulmonary perturbations, decrements in exercise capacity, and debilitating symptoms…”
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The Lymphangiogenic Vascular Endothelial Growth Factors VEGF-C and -D Are Ligands for the Integrin α9β1 by Vlahakis, Nicholas E., Young, Bradford A., Atakilit, Amha, Sheppard, Dean

“…Mice homozygous for a null mutation of the integrin α9 subunit die 6–12 days after birth from bilateral chylothoraces suggesting an underlying defect in…”
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Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study by Lamontagne, Francois, McIntyre, Lauralyn, Dodek, Peter, Heels-Ansdell, Diane, Meade, Maureen, Pemberton, Julia, Skrobik, Yoanna, Seppelt, Ian, Vlahakis, Nicholas E, Muscedere, John, Reece, Graham, Ostermann, Marlies, Padayachee, Soundrie, Alhashemi, Jamal, Walsh, Michael, Lewis, Bradley, Schiff, David, Moody, Alan, Zytaruk, Nicole, Leblanc, Martine, Cook, Deborah J

“…Critically ill patients are at risk of venous thrombosis, and therefore guidelines recommend daily thromboprophylaxis. Deep vein thrombosis (DVT) commonly…”
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Caveolin: Another reason why lipid membranes play an important role in ventilator-induced lung injury by Vlahakis, Nicholas E

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Achalasia: A Diagnosis That's Hard to Swallow by AJANI, Shahnaz, SHAH, Neel B, VLAHAKIS, Nicholas E

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Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin α9β1 by Oommen, Saji, Gupta, Shiv K., Vlahakis, Nicholas E.

“…Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a number of diverse extracellular ligands. We have shown previously…”
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Stretch induces cytokine release by alveolar epithelial cells in vitro by Vlahakis, N E, Schroeder, M A, Limper, A H, Hubmayr, R D

“…Mechanical ventilation can injure the lung, causing edema and alveolar inflammation. Interleukin-8 (IL-8) plays an important role in this inflammatory…”
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