Search Results - "VIVET, Sonia"

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos by Vitale, Ilio, Senovilla, Laura, Jemaà, Mohamed, Michaud, Mickaël, Galluzzi, Lorenzo, Kepp, Oliver, Nanty, Lisa, Criollo, Alfredo, Rello-Varona, Santiago, Manic, Gwenola, Métivier, Didier, Vivet, Sonia, Tajeddine, Nicolas, Joza, Nicholas, Valent, Alexander, Castedo, Maria, Kroemer, Guido

“…Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only…”
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Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway by Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Nanty, Lisa, Dessen, Philippe, Senovilla, Laura, Olaussen, Ken A, Lazar, Vladimir, Prudhomme, Michelle, Golsteyn, Roy M, Castedo, Maria, Kroemer, Guido

“…Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly…”
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Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells by Vitale, Ilio, Senovilla, Laura, Galluzzi, Lorenzo, Criollo, Alfredo, Vivet, Sonia, Castedo, Maria, Kroemer, Guido

“…We have previously shown that tetraploid cancer cells succumb through a p53-dependent apoptotic pathway when checkpoint kinase 1 (Chk1) is depleted by small…”
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p53 represses the polyploidization of primary mammary epithelial cells by activating apoptosis by Senovilla, Laura, Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Joza, Nicholas, Younes, Amena Ben, Rello-Varona, Santiago, Castedo, Maria, Kroemer, Guido

“…Tetraploidy may constitute a metastable state leading to numeric and structural chromosome abnormalities that are associated with cancer. Here, we show that…”
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Preapoptotic Chromatin Condensation Upstream of the Mitochondrial Checkpoint by Andreau, Karine, Castedo, Maria, Perfettini, Jean-Luc, Roumier, Thomas, Pichart, Evelyne, Souquere, Sylvie, Vivet, Sonia, Larochette, Nathanael, Kroemer, Guido

“…When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci…”
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Hafnium oxide nanoparticles: toward an in vitro predictive biological effect? by Marill, Julie, Anesary, Naeemunnisa Mohamed, Zhang, Ping, Vivet, Sonia, Borghi, Elsa, Levy, Laurent, Pottier, Agnes

“…Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The purpose of this…”
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Abstract 5193: Hafnium oxide nanoparticles (NBTXR3), a novel radiation enhancer achieves marked antitumor efficacy across five tumor types by Zhang, Ping, Vivet, Sonia, Paris, Sébastien, Pottier, Agnès

“…Abstract NBTXR3 are hafnium oxide nanoparticles (NPs) used for a single intratumor administration as radioenhancer in combination with radiation therapy (RT)…”
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Abstract 5183: The radioenhancer NBTXR3 brings anticancer efficacy to the cisplatin-based chemoradiation in vitro and in vivo by Pottier, Agnès, Vivet, Sonia, Paris, Sébastien, Lu, Bo

“…Abstract NBTXR3 is a radioenhancer composed of functionalized hafnium oxide nanoparticles, designed to enhance the radiation dose deposit within the cancer…”
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Apoptosis regulation in tetraploid cancer cells by Castedo, Maria, Coquelle, Arnaud, Vivet, Sonia, Vitale, Ilio, Kauffmann, Audrey, Dessen, Philippe, Pequignot, Marie O, Casares, Noelia, Valent, Alexandre, Mouhamad, Shahul, Schmitt, Elise, Modjtahedi, Nazanine, Vainchenker, William, Zitvogel, Laurence, Lazar, Vladimir, Garrido, Carmen, Kroemer, Guido

“…Tetraploidy can result in cancer‐associated aneuploidy. As shown here, freshly generated tetraploid cells arising due to mitotic slippage or failed cytokinesis…”
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Selective Resistance of Tetraploid Cancer Cells against DNA Damage-Induced Apoptosis by CASTEDO, MARIA, COQUELLE, ARNAUD, VITALE, ILIO, VIVET, SONIA, MOUHAMAD, SHAHUL, VIAUD, SOPHIE, ZITVOGEL, LAURENCE, KROEMER, GUIDO

“…:  Aneuploidy and chromosomal instability, which are frequent in cancer, can result from the asymmetric division of tetraploid precursors. Genomic instability…”
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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone by HOFFMANN, Jens, VILALE, Ilio, PANARETAKIS, Theocharis, SIEMEISTER, Gerhard, LAGE, Hermann, NANTY, Lisa, HAMMER, Stefanie, MITTELSTAEDT, Kevin, WINSEL, Sebastian, ESCHENBRENNER, Julia, CASTEDO, Maria, DEMARCHE, Carine, BUCHMANN, Bernd, KLAR, Ulrich, KROEMER, Guido, GALLUZZI, Lorenzo, SCHWEDE, Wolfgang, SENOVILLA, Laura, SKUBALLA, Werner, VIVET, Sonia, LICHTNER, Rosemarie B, VICENCIO, José M

“…Sagopilone (ZK-EPO) is the first fully synthetic epothilone undergoing clinical trials for the treatment of human tumors. Here, we investigate the cellular…”
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The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines’ in-vitro and in-vivo xenografts by Deberne, Mélanie, Levy, Antonin, Mondini, Michele, Dessen, Philippe, Vivet, Sonia, Supiramaniam, Ajitha, Vozenin, Marie-Catherine, Deutsch, Eric

“…Cervical carcinoma remains a leading cause of female mortality worldwide and over 90% of these tumors contain the human papillomavirus (HPV) genome. Cross-talk…”
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Abstract 2665: NBTXR3 hafnium oxide nanoparticle activated by ionizing radiation demonstrates marked radio-enhancement and antitumor effect via high energy deposit in human soft tissue sarcoma by Laurence, Maggiorella, Darmon, Audrey, Vivet, Sonia, Polrot, Mélanie, Zhang, Ping, Deutsch, Eric, Bourhis, Jean, Pottier, Agnès, Borghi, Elsa, Levy, Laurent

“…Abstract Local and systemic control of Soft Tissue Sarcoma (STS) remains a clinical challenge. Radiation therapy is part of the standard of care of STS. The…”
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Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis by Coquelle, Arnaud, Mouhamad, Shahul, Pequignot, Marie O., Braun, Thorsten, Carvalho, Gabrielle, Vivet, Sonia, Métivier, Didier, Castedo, Maria, Kroemer, Guido

“…The susceptibility of cells to apoptosis induction is deeply influenced by their position in the cell cycle. Unfortunately, however, current methods for the…”
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Hafnium oxide nanoparticles: toward an in vitropredictive biological effect? by Marill, Julie, Anesary, Naeemunnisa Mohamed, Zhang, Ping, Vivet, Sonia, Borghi, Elsa, Levy, Laurent, Pottier, Agnes

“…Background Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The…”
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Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells by Vitale, Ilio, Senovilla, Laura, Galluzzi, Lorenzo, Criollo, Alfredo, Vivet, Sonia, Castedo, Maria, Kroemer, Guido

“…We have previously shown that tetraploid cancer cells succumb through a p53-dependent apoptotic pathway when checkpoint kinase 1 (Chk1) is depleted by small…”
Get full text