Search Results - "VIUFF, D."

Enhancing the pharmacokinetic properties of recombinant factor VIII: first‐in‐human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A by Tiede, A., Brand, B., Fischer, R., Kavakli, K., Lentz, S. R., Matsushita, T., Rea, C., Knobe, K., Viuff, D.

“…Summary Background N8‐GP is a recombinant factor VIII (FVIII) with a site‐directed glycoPEGylation for the purpose of half‐life prolongation. Objectives To…”
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International comparative field study of N8 evaluating factor VIII assay performance by VIUFF, D., BARROWCLIFFE, TW, SAUGSTRUP, T., EZBAN, M., LILLICRAP, D.

“…Discrepancies between the one‐stage clotting assay and the chromogenic method, and also among different variations of each method, have been a significant…”
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Bioequivalence between two serum-free recombinant factor VIII preparations (N8 and ADVATE®) - an open-label, sequential dosing pharmacokinetic study in patients with severe haemophilia A by MARTINOWITZ, U., BJERRE, J., BRAND, B., KLAMROTH, R., MISGAV, M., MORFINI, M., SANTAGOSTINO, E., TIEDE, A., VIUFF, D.

“…Recombinant coagulation factor VIII (rFVIII) concentrates provide a safe and efficacious replacement therapy for treatment and prevention of bleeding in…”
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Functional characteristics of N8, a new recombinant FVIII by CHRISTIANSEN, M. L. S., BALLING, K. W., PERSSON, E., HILDEN, I., BAGGER-SØRENSEN, A., SØRENSEN, B. B., VIUFF, D., SEGEL, S., KLAUSEN, N. K., EZBAN, M., LETHAGEN, S., STEENSTRUP, T. D., KJALKE, M.

“…The aim of this study was to evaluate the in vitro function of the new recombinant factor VIII (FVIII) compound, N8. The specific activity of N8 as measured in…”
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Effects of in vivo prematuration and in vivo final maturation on developmental capacity and quality of pre-implantation embryos by Dieleman, S.J, Hendriksen, P.J.M, Viuff, D, Thomsen, P.D, Hyttel, P, Knijn, H.M, Wrenzycki, C, Kruip, T.A.M, Niemann, H, Gadella, B.M, Bevers, M.M, Vos, P.L.A.M

“…In current in vitro production (IVP) systems, oocytes lack in vivo dominant and preovulatory follicular development, which may compromise pregnancy and…”
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Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven®) by Viuff, D., Lauritzen, B., Pusateri, A.E., Andersen, S., Rojkjaer, R., Johansson, P.I.

“…A range of plasma volume expanders is used clinically, often in settings where haemostasis may already be impaired. The haemostatic agent, recombinant…”
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Ribosomal RNA gene expression and chromosome aberrations in bovine oocytes and preimplantation embryos by Hyttel, P, Viuff, D, Fair, T, Laurincik, J, Thomsen, PD, Callesen, H, Vos, PL, Hendriksen, PJ, Dieleman, SJ, Schellander, K, Besenfelder, U, Greve, T

“…This review focuses on the key features of development of the bovine oocyte and embryo, with comparisons of the developmental characteristics of embryos…”
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Transcriptional activity in in vitro produced bovine two- and four-cell embryos by Viuff, D., Avery, B., Greve, T., King, W.A., Hyttel, P.

“…The objectives of this study on in vitro produced bovine two‐ and four‐cell embryos were (1) to investigate the uptake of 3H‐uridine through the plasma…”
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Chromosomal Abnormalities and Developmental Kinetics in In Vivo-Developed Cattle Embryos at Days 2 to 5 after Ovulation by VIUFF, Dorthe, HENDRIKSEN, Peter J. M, VOS, Peter L. A. M, DIELEMAN, Steph J, BIBBY, Bo M, GREVE, Torben, HYTTEL, Poul, THOMSEN, Preben D

“…The frequency of chromosome abnormalities was investigated in cattle embryos (n = 256) derived from superovulated heifers (n = 35) on Days 2, 3, 4, and 5…”
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Morphological assessment of preimplantation embryo quality in cattle by Maddox-Hyttell, P, Gjørret, J O, Vajta, G, Alexopoulos, N I, Lewis, I, Trounson, A, Viuff, D, Laurincik, J, Müller, M, Tveden-Nyborg, P, Thomsen, P D

“…The extensive use of embryo technologies has emphasized the need for assessing embryo quality by morphological techniques, such as transmission electron…”
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Transcription and cell cycle-dependent development of intranuclear bodies and granules in two-cell bovine embryos by Hyttel, P, Viuff, D, Avery, B, Laurincik, J, Greve, T

“…Bovine two-cell embryos were produced by maturation and fertilization in vitro and isolated at 27, 30 or 33 h after insemination. Embryos were incubated with […”
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Activation of ribosomal RNA genes in preimplantation cattle and swine embryos by Hyttel, P, Laurincik, J, Viuff, D, Fair, T, Zakhartchenko, V, Rosenkranz, C, Avery, B, Rath, D, Niemann, H, Thomsen, P.D, Schellander, K, Callesen, H, Wolf, E, Ochs, R.L, Greve, T

“…Transcription of ribosomal RNA (rRNA) genes occurs in the nucleolus resulting in ribosome synthesis. In cattle and swine embryos, functional…”
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Transcriptional activity in in vivo developed early cleavage stage bovine embryos by Hay-Schmidt, A., Viuff, D., Greve, T., Hyttel, P.

“…Bovine embryos developed in vivo from the first to the fourth post-fertilization cell cycles were processed for ultrastructural autoradiography after…”
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Risks of in-vitro production of cattle and swine embryos: aberrations in chromosome numbers, ribosomal RNA gene activation and perinatal physiology by Hyttel, P., Viuff, D., Laurincik, J., Schmidt, M., Thomsen, P.D., Avery, B., Callesen, H., Rath, D., Niemann, H., Rosenkranz, H., Schellander, K., Ochs, R.L., Greve, T.

“…In cattle, in-vitro production (IVP) of embryos has become a standardized technique; however, increased frequencies of calving problems and larger calves have…”
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Time course of pronuclear deoxyribonucleic acid synthesis in parthenogenetically activated bovine oocytes by Soloy, E, Kanka, J, Viuff, D, Smith, S.D, Callesen, H, Greve, T

“…The progress of pronuclear DNA synthesis was monitored by the radioactive precursor 3H-thymidine during the first cell cycle of parthenogenetically activated…”
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Ribosomal ribonucleic acid is transcribed at the 4-cell stage in in vitro-produced bovine embryos by Viuff, D. (Royal Veterinary and Agricultural University, Frederiksberg, Denmark.), Hyttel, P, Avery, B, Vajta, G, Greve, T, Callesen, H, Thomsen, P.D

“…Ribosomal RNA, rRNA genes, and silver-staining nucleolar proteins were visualized in in vitro-produced bovine embryos from the 2-cell stage to the blastocyst…”
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Transcription and localization of growth factor mRNA in the bovine oviduct by Viuff, D, Hyttel, P, Greve, T, Eriksen, T, Alexandersen, S

“…It has become evident that certain growth factors are involved in the regulation of the initial bovine embryogenesis. In the present study, we examined by…”
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Expression of insulin-like growth factors in two bovine oviductal cultures employed for embryo co-culture by Xia, P, Han, V K, Viuff, D, Armstrong, D T, Watson, A J

“…We have investigated the patterns of expression and cellular localization of polypeptides and mRNAs encoding IGF-I and IGF-II in intact bovine oviduct and two…”
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Transcription and cell cycle-dependent development of intranuclear bodies and granules in two-cell bovine embryos by Hyttel, P., Viuff, D., Avery, B., Laurincik, J., Greve, T.

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International comparative field study of N8 evaluating factor VIII assay performance: N8 FIELD STUDY EVALUATING FVIII ASSAYS by VIUFF, D., BARROWCLIFFE, TW, SAUGSTRUP, T., EZBAN, M., LILLICRAP, D.

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