Search Results - "VITA, Patrizia"

5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions by Luongo, Livio, Petrelli, Riccardo, Gatta, Luisa, Giordano, Catia, Guida, Francesca, Vita, Patrizia, Franchetti, Palmarisa, Grifantini, Mario, Novellis, Vito de, Cappellacci, Loredana, Maione, Sabatino

“…This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of…”
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Novel inhibitors of inosine monophosphate dehydrogenase in patent literature of the last decade by Petrelli, Riccardo, Vita, Patrizia, Torquati, Ilaria, Felczak, Krzysztof, Wilson, Daniel J, Franchetti, Palmarisa, Cappellacci, Loredana

“…Inosine monophosphate dehydrogenase (IMPDH), an NAD-dependent enzyme that controls de novo synthesis of guanine nucleotides, has received considerable interest…”
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Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A 1 Adenosine Receptor Agonists by Petrelli, Riccardo, Scortichini, Mirko, Belardo, Carmela, Boccella, Serena, Luongo, Livio, Capone, Fabio, Kachler, Sonja, Vita, Patrizia, Del Bello, Fabio, Maione, Sabatino, Lavecchia, Antonio, Klotz, Karl-Norbert, Cappellacci, Loredana

“…Our previous work discovered that combining the appropriate 5'- and N -substitution in adenosine derivatives leads to the highly selective human A adenosine…”
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Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists by Petrelli, Riccardo, Scortichini, Mirko, Belardo, Carmela, Boccella, Serena, Luongo, Livio, Capone, Fabio, Kachler, Sonja, Vita, Patrizia, Del Bello, Fabio, Maione, Sabatino, Lavecchia, Antonio, Klotz, Karl-Norbert, Cappellacci, Loredana

“…Our previous work discovered that combining the appropriate 5′- and N 6-substitution in adenosine derivatives leads to the highly selective human A1 adenosine…”
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From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3′-C-methyladenosine by Petrelli, Riccardo, Meli, Maria, Vita, Patrizia, Torquati, Ilaria, Ferro, Arianna, Vodnala, Munender, D’Alessandro, Natale, Tolomeo, Manlio, Del Bello, Fabio, Kusumanchi, Praveen, Franchetti, Palmarisa, Grifantini, Mario, Jayaram, Hiremagalur N., Hofer, Anders, Cappellacci, Loredana

“…[Display omitted] We synthesized a series of serum-stable covalently linked drugs derived from 3′-C-methyladenosine (3′-Me-Ado) and valproic acid (VPA), which…”
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Synthesis and biological activity of novel N 6-substituted and 2, N 6-disubstituted adenine ribo- and 3′- C-methyl-ribonucleosides as antitumor agents by Cappellacci, Loredana, Petrelli, Riccardo, Franchetti, Palmarisa, Vita, Patrizia, Kusumanchi, Praveen, Kumar, Mohineesh, Jayaram, Hiremagalur N., Zhou, Bingsen, Yen, Yun, Grifantini, Mario

“…A series of N 6-aminopurine-9- β- d-ribonucleosides and ribose-modified 3′- C-methyl analogues substituted at N 6-position with a small group like hydroxy,…”
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5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions by Luongo, Livio, Petrelli, Riccardo, Gatta, Luisa, Giordano, Catia, Guida, Francesca, Vita, Patrizia, Franchetti, Palmarisa, Grifantini, Mario, de Novellis, Vito, Cappellacci, Loredana, Maione, Sabatino

“…This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of…”
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Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N 6-Substituted 3′-C-Methyladenosine Derivatives by Cappellacci, Loredana, Franchetti, Palmarisa, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Jayaram, Hiremagalur N, Saiko, Philipp, Graser, Geraldine, Szekeres, Thomas, Grifantini, Mario

“…A series of cycloalkyl, bicycloalkyl, aryl, and heteroaryl N 6-substituted derivatives of the antitumor agent 3′-C-methyladenosine (3′-Me-Ado), an inhibitor of…”
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5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists : Affinity, efficacy, and selectivity for A1 receptor from different species by CAPPELLACCI, Loredana, FRANCHETTI, Palmarisa, VITA, Patrizia, PETRELLI, Riccardo, LAVECCHIA, Antonio, COSTA, Barbara, SPINETTI, Francesca, MARTINI, Claudia, KLOTZ, Karl-Norbert, GRIFANTINI, Mario

“…A series of 5'-carbamoyl and 5'-thionocarbamoyl derivatives of 2'-C-methyl analogues of the A(1) adenosine receptor (A(1)AR) full agonists…”
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Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents by CAPPELLACCI, Loredana, PETRELLI, Riccardo, FRANCHETTI, Palmarisa, VITA, Patrizia, KUSUMANCHI, Praveen, KUMAR, Mohineesh, JAYARAM, Hiremagalur N, BINGSEN ZHOU, YUN YEN, GRIFANTINI, Mario

“…A series of N6-aminopurine-9-β-D-ribonucleosides and ribose-modified 3'-C-methyl analogues substituted at N6-position with a small group like hydroxy, methoxy…”
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N 6 -Cycloalkyl- and N 6 -Bicycloalkyl- C 5′( C 2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A 1 Adenosine Receptor with Antinociceptive Effects in Mice by Franchetti, Palmarisa, Cappellacci, Loredana, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Kachler, Sonja, Klotz, Karl-Norbert, Marabese, Ida, Luongo, Livio, Maione, Sabatino, Grifantini, Mario

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N 6 -Cycloalkyl- and N 6 -Bicycloalkyl- C 5′( C 2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A 1 Adenosine Receptor with Antinociceptive Effects in Mice by Franchetti, Palmarisa, Cappellacci, Loredana, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Kachler, Sonja, Klotz, Karl-Norbert, Marabese, Ida, Luongo, Livio, Maione, Sabatino, Grifantini, Mario

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N6-Cycloalkyl-and N6-Bicycloalkyl-C5'(C2')-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1 Adenosine Receptor with Antinociceptive Effects in Mice by FRANCHETTI, Palmarisa, CAPPELLACCI, Loredana, GRIFANTINI, Mario, VITA, Patrizia, PETRELLI, Riccardo, LAVECCHIA, Antonio, KACHLER, Sonja, KLOTZ, Karl-Norbert, MARABESE, Ida, LUONGO, Livio, MAIONE, Sabatino

“…To further investigate new potent and selective human A(1) adenosine receptor agonists, we have synthesized a series of 5'-chloro-5'-deoxy- and…”
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Antitumor Activity of C-Methyl-β-d-ribofuranosyladenine Nucleoside Ribonucleotide Reductase Inhibitors by Franchetti, Palmarisa, Cappellacci, Loredana, Pasqualini, Michela, Petrelli, Riccardo, Vita, Patrizia, Jayaram, Hiremagalur N, Horvath, Zsuzsanna, Szekeres, Thomas, Grifantini, Mario

“…A series of adenosine derivatives substituted at the 1‘-, 2‘-, or 3‘-position of the ribose ring with a methyl group was synthesized and evaluated for…”
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Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists by Cappellacci, Loredana, Franchetti, Palmarisa, Pasqualini, Michela, Petrelli, Riccardo, Vita, Patrizia, Lavecchia, Antonio, Novellino, Ettore, Costa, Barbara, Martini, Claudia, Klotz, Karl-Norbert, Grifantini, Mario

“…A number of 3‘-C-methyl analogues of selective adenosine receptor agonists such as CPA, CHA, CCPA, 2‘-Me-CCPA, NECA, and IB-MECA was synthesized to further…”
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First TiCl4-Mediated Diastereoselective Reduction of α-Nitro Ketones to Anti-β-Nitro Alcohols by BH3·SMe2 by BALLINI, Roberto, BOSICA, Giovanna, MARCANTONI, Enrico, VITA, Patrizia, BARTOLI, Giuseppe

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Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N6-Substituted 3′-C-Methyladenosine Derivatives by CAPPELLACCI, Loredana, FRANCHETTI, Palmarisa, VITA, Patrizia, PETRELLI, Riccardo, LAVECCHIA, Antonio, JAYARAM, Hiremagalur N., SAIKO, Philipp, GRASER, Geraldine, SZEKERES, Thomas, GRIFANTINI, Mario

“…A series of cycloalkyl, bicycloalkyl, aryl, and heteroaryl N (6)-substituted derivatives of the antitumor agent 3'- C-methyladenosine (3'-Me-Ado), an inhibitor…”
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Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs by Franchetti, Palmarisa, Pasqualini, Michela, Petrelli, Riccardo, Ricciutelli, Massimo, Vita, Patrizia, Cappellacci, Loredana

“…A stereoselective synthesis of β-anomers of nicotinamide riboside (NAR), its deamidated analog (NaR), and of a nicotinamide C-methylated riboside derivative…”
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5′-Carbamoyl derivatives of 2′- C-methyl-purine nucleosides as selective A 1 adenosine receptor agonists: Affinity, efficacy, and selectivity for A 1 receptor from different species by Cappellacci, Loredana, Franchetti, Palmarisa, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Costa, Barbara, Spinetti, Francesca, Martini, Claudia, Klotz, Karl-Norbert, Grifantini, Mario

“…A series of 5′-carbamoyl and 5′-thionocarbamoyl derivatives of 2′- C-methyl analogues of the A 1 adenosine receptor (A 1AR) full agonists N…”
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First TiCl 4 -Mediated Diastereoselective Reduction of α-Nitro Ketones to A nti -β-Nitro Alcohols by BH 3 ·SMe 2 by Ballini, Roberto, Bosica, Giovanna, Marcantoni, Enrico, Vita, Patrizia, Bartoli, Giuseppe

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