Search Results - "VISSE, Robert"

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 by Manka, Szymon W, Carafoli, Federico, Visse, Robert, Bihan, Dominique, Raynal, Nicolas, Farndale, Richard W, Murphy, Gillian, Enghild, Jan J, Hohenester, Erhard, Nagase, Hideaki

“…Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and…”
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Carcinomas Contain a Matrix Metalloproteinase-Resistant Isoform of Type I Collagen Exerting Selective Support to Invasion by MAKAREEVA, Elena, SEJIN HAN, VERA, Juan Carlos, SACKETT, Dan L, HOLMBECK, Kenn, PHILLIPS, Charlotte L, VISSE, Robert, NAGASE, Hideaki, LEIKIN, Sergey

“…Collagen fibers affect metastasis in two opposing ways, by supporting invasive cells but also by generating a barrier to invasion. We hypothesized that these…”
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Crystal Structure of an Active Form of Human MMP-1 by Iyer, Shalini, Visse, Robert, Nagase, Hideaki, Acharya, K. Ravi

“…The extracellular matrix is a dynamic environment that constantly undergoes remodelling and degradation during vital physiological processes such as…”
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Catalytic Properties of ADAM12 and Its Domain Deletion Mutants by Jacobsen, Jonas, Visse, Robert, Sørensen, Hans Peter, Enghild, Jan J, Brew, Keith, Wewer, Ulla M, Nagase, Hideaki

“…Human ADAM12 (a disintegrin and metalloproteinase) is a multidomain zinc metalloproteinase expressed at high levels during development and in human tumors…”
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The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain by Tochowicz, Anna, Goettig, Peter, Evans, Richard, Visse, Robert, Shitomi, Yasuyuki, Palmisano, Ralf, Ito, Noriko, Richter, Klaus, Maskos, Klaus, Franke, Daniel, Svergun, Dmitri, Nagase, Hideaki, Bode, Wolfram, Itoh, Yoshifumi

“…Homodimerization is an essential step for membrane type 1 matrix metalloproteinase (MT1-MMP) to activate proMMP-2 and to degrade collagen on the cell surface…”
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Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry by Visse, Robert, Nagase, Hideaki

“…ABSTRACT—Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role…”
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MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1 by Yamamoto, Kazuhiro, Okano, Hiroshi, Miyagawa, Wakako, Visse, Robert, Shitomi, Yasuyuki, Santamaria, Salvatore, Dudhia, Jayesh, Troeberg, Linda, Strickland, Dudley K., Hirohata, Satoshi, Nagase, Hideaki

“…Matrix metalloproteinase 13 (MMP-13) degrades collagenous extracellular matrix and its aberrant activity associates with diseases such as arthritis, cancer,…”
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Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System by Yu, Zhuoxin, Visse, Robert, Inouye, Masayori, Nagase, Hideaki, Brodsky, Barbara

“…Degradation of fibrillar collagens is important in many physiological and pathological events. These collagens are resistant to most proteases due to the…”
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The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity by Minond, Dmitriy, Lauer-Fields, Janelle L., Cudic, Mare, Overall, Christopher M., Pei, Duanqing, Brew, Keith, Visse, Robert, Nagase, Hideaki, Fields, Gregg B.

“…The hydrolysis of collagen (collagenolysis) is one of the committed steps in extracellular matrix turnover. Within the matrix metalloproteinase (MMP) family…”
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Structure and function of matrix metalloproteinases and TIMPs by NAGASE, Hideaki, VISSE, Robert, MURPHY, Gillian

“…Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins…”
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X-ray Structure of Human proMMP-1 by Jozic, Daniela, Bourenkov, Gleb, Lim, Ngee-Han, Visse, Robert, Nagase, Hideaki, Bode, Wolfram, Maskos, Klaus

“…Vertebrate collagenases, members of the matrix metalloproteinase (MMP) family, initiate interstitial fibrillar collagen breakdown. It is essential in many…”
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No influence of human herpesvirus 8 infection on the progression of HIV-1 infection in initially asymptomatic patients by AIT-ARKOUB, Zaïna, ROBERT-VISSE, Catherine, CALVEZ, Vincent, COSTAGLIOLA, Dominique, AUTRAN, Brigitte, CANDOTTI, Daniel, AGUT, Henri

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Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity by Doherty, Christine M, Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K, Nagase, Hideaki, Troeberg, Linda

“…Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels…”
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Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage by Mekkat, Arya, Poppleton, Erik, An, Bo, Visse, Robert, Nagase, Hideaki, Kaplan, David L., Brodsky, Barbara, Lin, Yu-Shan

“…•Native type I collagen heterotrimers are readily cleaved by MMP-1, while α1(I) homotrimers are not.•Recombinant homotrimers containing the α2(I) cleavage…”
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Distinct biological events generated by ECM proteolysis by two homologous collagenases by Solomonov, Inna, Zehorai, Eldar, Talmi-Frank, Dalit, Wolf, Sharon G., Shainskaya, Alla, Zhuravlev, Alina, Kartvelishvily, Elena, Visse, Robert, Levin, Yishai, Kampf, Nir, Jaitin, Diego Adhemar, David, Eyal, Amit, Ido, Nagase, Hideaki, Sagi, Irit

“…It is well established that the expression profiles of multiple and possibly redundant matrix-remodeling proteases (e.g., collagenases) differ strongly in…”
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Crystal structure of full‐length human collagenase 3 (MMP‐13) with peptides in the active site defines exosites in the catalytic domain by Stura, Enrico A., Visse, Robert, Cuniasse, Philippe, Dive, Vincent, Nagase, Hideaki

“…Matrix metalloproteinase (MMP)‐13 is one of the mammalian collagenases that play key roles in tissue remodelling and repair and in progression of diseases such…”
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The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage by Howes, Joanna-Marie, Bihan, Dominique, Slatter, David A, Hamaia, Samir W, Packman, Len C, Knauper, Vera, Visse, Robert, Farndale, Richard W

“…Remodeling of collagen by matrix metalloproteinases (MMPs) is crucial to tissue homeostasis and repair. MMP-13 is a collagenase with a substrate preference for…”
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Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases by Han, Sejin, Makareeva, Elena, Kuznetsova, Natalia V., DeRidder, Angela M., Sutter, Mary Beth, Losert, Wolfgang, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey

“…Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal…”
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Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective ActivityThis work was supported by a Kennedy Trust for Rheumatology Research Doctoral Scholarship (to C. D.) and an Arthritis Research UK Career Development Fellowship (Grant 19466) (to L. T.). The work was additionally supported by the Arthritis Research UK Centre for Osteoarthritis Pathogenesis (Grant 20205); NIAMS, National Institutes of Health, Grant AR40994 (to H. N.); and by Doherty, Christine M., Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K., Nagase, Hideaki, Troeberg, Linda

“…Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a central inhibitor of matrix-degrading and sheddase families of metalloproteinases. Extracellular levels…”
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Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS by Tochowicz, Anna, Goettig, Peter, Evans, Richard, Visse, Robert, Shitomi, Yasuyuki, Palmisano, Ralf, Ito, Noriko, Richter, Klaus, Maskos, Klaus, Franke, Daniel, Svergun, Dmitri, Nagase, Hideaki, Bode, Wolfram, Itoh, Yoshifumi

“…Homodimerization is an essential step for membrane type 1 matrix metalloproteinase (MT1-MMP) to activate proMMP-2 and to degrade collagen on the cell surface…”
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