Search Results - "VISBAL, Gonzalo"

Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations by de Macedo-Silva, Sara Teixeira, Visbal, Gonzalo, Souza, Gabrielle Frizzo, dos Santos, Mayara Roncaglia, Cämmerer, Simon B., de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes

“…Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds selectively designed to…”
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Zinc(II)-Sterol Hydrazone Complex as a Potent Anti- Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action by Visbal, Gonzalo, Justo, Rodrigo M S, Dos Santos da Silva E Miranda, Gabrielle, Teixeira de Macedo Silva, Sara, de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes, Navarro, Maribel

“…Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against of the new ZnCl ( )…”
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Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana by SERRANO-MARTIN, Xenon, GARCIA-MARCHAN, Yael, FERNANDEZ, Alexis, RODRIGUEZ, Noris, ROJAS, Hector, VISBAL, Gonzalo, BENAIM, Gustavo

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Trypanosoma cruzi Epimastigotes Are Able to Manage Internal Cholesterol Levels under Nutritional Lipid Stress Conditions by Pereira, Miria Gomes, Visbal, Gonzalo, Salgado, Leonardo T, Vidal, Juliana Cunha, Godinho, Joseane L P, De Cicco, Nuccia N T, Atella, Geórgia C, de Souza, Wanderley, Cunha-e-Silva, Narcisa

“…Trypanosoma cruzi epimastigotes store high amounts of cholesterol and cholesteryl esters in reservosomes. These unique organelles are responsible for cellular…”
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Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B by Ishida, Kelly, Rozental, Sonia, Visbal, Gonzalo, Rodrigues, Juliany Cola Fernandes, de Souza, Wanderley, Urbina, Julio A

“…Abstract Three quinuclidine-based squalene synthase (SQS) inhibitors (BPQ-OH, E5700, and ER-119884) were evaluated against five Candida tropicalis strains with…”
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Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana by Urbina, Julio A, Concepcion, Juan Luis, Rangel, Salomé, Visbal, Gonzalo, Lira, Renee

“…Trypanosoma cruzi and Leishmania parasites have a strict requirement for specific endogenous sterols (ergosterol and analogs) for survival and growth and…”
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Asymmetric Synthesis of Four Diastereomers of 3-Hydroxy-2,4,6-trimethylheptanoic Acid:  Proof of Configurational Assignment by Turk, Jeffrey A, Visbal, Gonzalo S, Lipton, Mark A

“…Four unique diastereomers of 3-hydroxy-2,4,6-trimethylheptanoic acid(2R,3R,4R), (2S,3R,4R), (2S,3R,4S), and (2R,3R,4S)the fatty acid component of callipeltin…”
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In Vitro Antiproliferative Effects and Mechanism of Action of the New Triazole Derivative UR-9825 against the Protozoan Parasite Trypanosoma (Schizotrypanum)cruzi by URBINA, J. A, LIRA, R, VISBAL, G, BARTROLF, J

“…ERRATUM ( vol. 44 , p. 2924 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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S-Adenosyl-l-Methionine Inhibitors Δ24-Sterol Methyltransferase and Δ24(28)-Sterol Methylreductase as Possible Agents against Paracoccidioides brasiliensis by Visbal, Gonzalo, Alvarez, Alvaro, Moreno, Belisario, San-Blas, Gioconda

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Copper(I)–Phosphine Polypyridyl Complexes: Synthesis, Characterization, DNA/HSA Binding Study, and Antiproliferative Activity by Villarreal, Wilmer, Colina-Vegas, Legna, Visbal, Gonzalo, Corona, Oscar, Corrêa, Rodrigo S, Ellena, Javier, Cominetti, Marcia Regina, Batista, Alzir Azevedo, Navarro, Maribel

“…A series of copper­(I)–phosphine polypyridyl complexes have been investigated as potential antitumor agents. The complexes [Cu­(PPh3)2­dpq]­NO3 (2),…”
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In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis by Teixeira de Macedo Silva, Sara, Visbal, Gonzalo, Lima Prado Godinho, Joseane, Urbina, Julio A, de Souza, Wanderley, Cola Fernandes Rodrigues, Juliany

“…Leishmaniasis, one of the most significant neglected diseases around the world, is caused by protozoan parasites of the Leishmania genus. Nowadays, the…”
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Zinc-Sterol Hydrazone Complex as a Potent Anti-ILeishmania/I Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action by Visbal, Gonzalo, Justo, Rodrigo M. S, dos Santos da Silva e Miranda, Gabrielle, Teixeira de Macedo Silva, Sara, de Souza, Wanderley, Rodrigues, Juliany Cola Fernandes, Navarro, Maribel

“…Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis…”
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Synthesis, in vitro antifungal activity and mechanism of action of four sterol hydrazone analogues against the dimorphic fungus Paracoccidioides brasiliensis by Visbal, Gonzalo, San-Blas, Gioconda, Maldonado, Alexis, Álvarez-Aular, Álvaro, Capparelli, Mario V., Murgich, Juan

“…[Display omitted] ► Efficient synthesis of novel Sterol hydrazones analogues. ► Antifungal activity was determinate on P. brasiliensis. ► Sterol hydrazones…”
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Δ(24)-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis by Borba-Santos, Luana P, Visbal, Gonzalo, Gagini, Thalita, Rodrigues, Anderson M, de Camargo, Zoilo P, Lopes-Bezerra, Leila M, Ishida, Kelly, de Souza, Wanderley, Rozental, Sonia

“…Inhibition of Δ(24)-sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro. The effects…”
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Sterol‐hydrazone derivatives as inhibitors of the fungal Δ24_sterol methyl transferase by San‐Blas, Gioconda, Visbal, Gonzalo, Murgich, Juan, Niño‐Vega, Gustavo

“…Fungal sterols differ from vertebrate ones in the presence of an extra alkyl group at C‐24, whose insertion is catalyzed by Δ(24)‐sterol methyl transferase…”
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Anti-trypanosomatid activity of platinum–sterol hydrazone imidazoline complexes by Navarro, Maribel, Marchán, Edgar, Maldonado, Alexis, Simoni, Zulay, Velásquez, Mariceny, Herrera, Leidi, Visbal, Gonzalo

“…In the search for effective and less toxic drugs against Leishmania mexicana and Trypanosoma cruzi parasites, two new complexes trans -[Pt(Him 1 ) 2 (Cl) 2 ] (…”
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Synthesis and characterization of platinum–sterol hydrazone complexes with biological activity against Leishmania (L.) mexicana by Visbal, Gonzalo, Marchán, Edgar, Maldonado, Alexis, Simoni, Zulay, Navarro, Maribel

“…Leishmaniasis is a parasitic zoonosis caused by protozoans of the genus Leishmania transmitted by insects known as phlebotomines, which are found in wild or…”
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Anti-leishmanial evaluation of C2-aryl quinolines: Mechanistic insight on bioenergetics and sterol biosynthetic pathway of Leishmania braziliensis by Bompart, Daznia, Núñez-Durán, Jorge, Rodríguez, Daniel, Kouznetsov, Vladimir V., Meléndez Gómez, Carlos M., Sojo, Felipe, Arvelo, Francisco, Visbal, Gonzalo, Alvarez, Alvaro, Serrano-Martín, Xenón, García-Marchán, Yael

“…A series of diverse simple C2-aryl quinolines was synthesized de novo via a straightforward synthesis based on the acid-catalyzed multicomponent imino…”
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Δ24-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis by Borba-Santos, Luana P., Visbal, Gonzalo, Gagini, Thalita, Rodrigues, Anderson M., de Camargo, Zoilo P., Lopes-Bezerra, Leila M., Ishida, Kelly, de Souza, Wanderley, Rozental, Sonia

“…Inhibition of Δ 24 -sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro . The effects…”
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Trypanosoma cruzi epimastigotes store cholesteryl esters in lipid droplets after cholesterol endocytosis by Pereira, Miria G., Visbal, Gonzalo, Costa, Tatiana F.R., Frases, Susana, de Souza, Wanderley, Atella, Geórgia, Cunha-e-Silva, Narcisa

“…[Display omitted] •We have isolated lipid droplets from Trypanosoma cruzi epimastigotes.•Lipid droplets are formed mostly by cholesteryl esters after…”
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