Search Results - "VIRKAMAKI, Antti"

High prevalence of chronic kidney disease in Finnish patients with type 2 diabetes treated in primary care by Metsärinne, Kaj, Bröijersen, Anders, Kantola, Ilkka, Niskanen, Leo, Rissanen, Aila, Appelroth, Tina, Pöntynen, Nora, Poussa, Tuija, Koivisto, Veikko, Virkamäki, Antti

“…Abstract Objective To examine the prevalence of chronic kidney disease (CKD) and related cardiovascular morbidity in a cross-sectional population in patients…”
Get full text

Improved control of blood pressure and albuminuria among patients with type-2 diabetes in Finnish open care by Varis, Juha, Metsärinne, Kaj, Koivisto, Veikko, Niskanen, Leo, Rissanen, Aila, Virkamäki, Antti, Appelroth, Tina, Pöntynen, Nora, Poussa, Tuija, Kantola, Ilkka

“…Risk of cardiovascular events within the diabetic population has decreased and survival increased with patients living longer and thus facing the development…”
Get full text

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance by Kahn, Barbara B, Zisman, Ariel, Peroni, Odile D, Abel, E. Dale, Michael, M. Dodson, Mauvais-Jarvis, Franck, Lowell, Bradford B, Wojtaszewski, Jørgen F.P, Hirshman, Michael F, Virkamaki, Antti, Goodyear, Laurie J, Kahn, C. Ronald

“…The prevalence of type 2 diabetes mellitus is growing worldwide. By the year 2020, 250 million people will be afflicted. Most forms of type 2 diabetes are…”
Get full text

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis by Koponen, Taina, Cerrada-Gimenez, Marc, Pirinen, Eija, Hohtola, Esa, Paananen, Jussi, Vuohelainen, Susanna, Tusa, Maija, Pirnes-Karhu, Sini, Heikkinen, Sami, Virkamäki, Antti, Uimari, Anne, Alhonen, Leena, Laakso, Markku

“…The mitochondrial biogenesis and energy expenditure regulator, PGC-1α, has been previously reported to be induced in the white adipose tissue (WAT) and liver…”
Get full text

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle by Patti, M E, Virkamäki, A, Landaker, E J, Kahn, C R, Yki-Järvinen, H

“…Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. M E…”
Get full text

Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy by Sutinen, Jussi, Kannisto, Katja, Korsheninnikova, Elena, Fisher, Rachel M, Ehrenborg, Ewa, Nyman, Tuulikki, Virkamäki, Antti, Funahashi, Tohru, Matsuzawa, Yuji, Vidal, Hubert, Hamsten, Anders, Yki-Järvinen, Hannele

“…Highly active antiretroviral therapy (HAART) has improved the prognosis of human immunodeficiency virus (HIV)-infected patients but is associated with severe…”
Get more information

Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus by MÄKIMATTILA, S, VIRKAMÄKI, A, GROOP, P.-H, COCKCROFT, J, UTRIAINEN, T, FAGERUDD, J, YKI-JÄRVINEN, H

“…We explored whether chronic hyperglycemia is associated with defects in endothelium-dependent vasodilatation in vivo and whether defects in the hemodynamic…”
Get full text

Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM by YKI-JÄRVINEN, H, DANIELS, M. C, VIRKAMÄKI, A, MÄKIMATTILA, S, DEFRONZO, R. A, MCCLAIN, D

“…Overactivity of the hexosamine pathway mediates glucose-induced insulin resistance in rat adipocytes. Glutamine:fructose-6-phosphate amidotransferase (GFA) is…”
Get full text

Occurrence and biological properties of a common genetic variant of luteinizing hormone by Haavisto, A M, Pettersson, K, Bergendahl, M, Virkamäki, A, Huhtaniemi, I

“…We have characterized the frequency and selected biological properties of a variant form of LH caused by two point mutations in the gene of the LH…”
Get more information

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance by Virkamäki, A, Ueki, K, Kahn, C R

Get full text

Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle by Virkamäki, Antti, Korsheninnikova, Elena, Seppälä-Lindroos, Anneli, Vehkavaara, Satu, Goto, Takashi, Halavaara, Juha, Häkkinen, Anna-Maija, Yki-Järvinen, Hannele

“…Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human…”
Get full text

Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart by A Virkamäki, H Yki-Järvinen

“…Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and…”
Get full text

Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women by VEHKAVAARA, Satu, WESTERBACKA, Jukka, HAKALA-ALA-PIETILÄ, Tiina, VIRKAMAKI, Antti, HOVATTA, Outi, YKI-JÄRVINEN, Hannele

“…In the present study, we hypothesized that estradiol, via its ability to vasodilate in an endothelium-dependent manner, might enhance vascular effects of…”
Get full text

Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism by Pirinen, Eija, Kuulasmaa, Teemu, Pietilä, Marko, Heikkinen, Sami, Tusa, Maija, Itkonen, Paula, Boman, Susanna, Skommer, Joanna, Virkamäki, Antti, Hohtola, Esa, Kettunen, Mikko, Fatrai, Szabolcs, Kansanen, Emilia, Koota, Suvi, Niiranen, Kirsi, Parkkinen, Jyrki, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo, Hiltunen, J. Kalervo, Alhonen, Leena, Smith, Ulf, Jänne, Juhani, Laakso, Markku

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Fasting plasma glucose variability as a marker of nocturnal hypoglycemia in diabetes: Evidence from the PREDICTIVE™ study by Niskanen, Leo, Virkamäki, Antti, Hansen, Jes B, Saukkonen, Tero

“…Abstract The relationship between fasting glucose (FG) variability and nocturnal hypoglycemia was assessed using longitudinal data from PREDICTIVE™, the…”
Get full text

Elevated fasting insulin concentrations associate with impaired insulin signaling in skeletal muscle of healthy subjects independent of obesity by Korsheninnikova, Elena, Seppälä-Lindroos, Anneli, Vehkavaara, Satu, Goto, Takashi, Virkamäki, Antti

“…Background Insulin signaling is impaired in the skeletal muscle of obese subjects but whether defects in skeletal muscle insulin signaling also characterize…”
Get full text

Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women by Vehkavaara, S, Silveira, A, Hakala-Ala-Pietilä, T, Virkamäki, A, Hovatta, O, Hamsten, A, Taskinen, M R, Yki-Järvinen, H

“…We compared the effects of oral estradiol (2 mg), transdermal estradiol (50 microg), and placebo on measures of coagulation, fibrinolysis, inflammation and…”
Get more information

Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women by VEHKAVAARA, Satu, HAKALA-ALA-PIETILÄ, Tiina, VIRKAMÄKI, Antti, BERGHOLM, Robert, EHNHOLM, Christian, HOVATTA, Outi, TASKINEN, Marja-Riitta, YKI-JÄRVINEN, Hannele

“…We determined whether the vascular effects of estradiol depend on the route of administration by comparing the effects of oral estradiol and transdermal…”
Get full text

Activation of the Hexosamine Pathway by Glucosamine in Vivo Induces Insulin Resistance in Multiple Insulin Sensitive Tissues by Virkamäki, Antti, Daniels, Marc C., Hämäläinen, Sari, Utriainen, Tapio, McClain, Don, Yki-Järvinen, Hannele

“…Abstract We determined the effect of infusion of glucosamine (GlcN), which bypasses the rate limiting reaction in the hexosamine pathway, on insulin-stimulated…”
Get full text

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes by Mauvais-Jarvis, F, Virkamaki, A, Michael, M D, Winnay, J N, Zisman, A, Kulkarni, R N, Kahn, C R

“…A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. F Mauvais-Jarvis , A…”
Get full text