Search Results - "VIRGILIO, L"

The Calcium Homeostasis of Human Red Blood Cells in Health and Disease: Interactions of PIEZO1, the Plasma Membrane Calcium Pump, and Gardos Channels by Lew, Virgilio L

“…Calcium ions mediate the volume homeostasis of human red blood cells (RBCs) in the circulation. The mechanism by which calcium ions affect RBC hydration states…”
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The circulatory dynamics of human red blood cell homeostasis: Oxy-deoxy and PIEZO1-triggered changes by Lew, Virgilio L.

“…The vital function of red blood cells (RBCs) is to mediate the transport of oxygen from lungs to tissues and of CO2 from tissues to lungs. The gas exchanges…”
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On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels by Lew, Virgilio L, Tiffert, Teresa

“…In a healthy adult, the transport of O and CO between lungs and tissues is performed by about 2 · 10 red blood cells, of which around 1.7 · 10 are renewed…”
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Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits by Rogers, Simon, Lew, Virgilio L

“…In this paper we apply a novel JAVA version of a model on the homeostasis of human red blood cells (RBCs) to investigate the changes RBCs experience during…”
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PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells by Rogers, Simon, Lew, Virgilio L

“…Human red blood cells (RBCs) have a circulatory lifespan of about four months. Under constant oxidative and mechanical stress, but devoid of organelles and…”
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What can mechanistic models tell us about guard cells, photosynthesis, and water use efficiency? by Blatt, Michael R., Jezek, Mareike, Lew, Virgilio L., Hills, Adrian

“…Stomatal pores facilitate gaseous exchange between the inner air spaces of the leaf and the atmosphere. The pores open to enable CO2 entry for photosynthesis…”
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OnGuard, a Computational Platform for Quantitative Kinetic Modeling of Guard Cell Physiology by Hills, Adrian, Chen, Zhong-Hua, Amtmann, Anna, Blatt, Michael R., Lew, Virgilio L.

“…Stomatal guard cells play a key role in gas exchange for photosynthesis while minimizing transpirational water loss from plants by opening and closing the…”
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A constraint–relaxation–recovery mechanism for stomatal dynamics by Jezek, Mareike, Hills, Adrian, Blatt, Michael R., Lew, Virgilio L.

“…Models of guard cell dynamics, built on the OnGuard platform, have provided quantitative insights into stomatal function, demonstrating substantial predictive…”
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Osmotic Vesicle Collapse of Sealed Inside–Out Membrane Vesicles From Red Blood Cells by Tiffert, Teresa, Lew, Virgilio L.

“…The preparation of plasma membrane vesicles from a large variety of cells has contributed a wealth of information on the identity and vectorial properties of…”
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Unexpected Connections between Humidity and Ion Transport Discovered Using a Model to Bridge Guard Cell-to-Leaf Scales by Wang, Yizhou, Hills, Adrian, Vialet-Chabrand, Silvere, Papanatsiou, Maria, Griffiths, Howard, Rogers, Simon, Lawson, Tracy, Lew, Virgilio L., Blatt, Michael R.

“…Stomatal movements depend on the transport and metabolism of osmotic solutes that drive reversible changes in guard cell volume and turgor. These processes are…”
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Systems Dynamic Modeling of the Stomatal Guard Cell Predicts Emergent Behaviors in Transport, Signaling, and Volume Control by Chen, Zhong-Hua, Hills, Adrian, Bätz, Ulrike, Amtmann, Anna, Lew, Virgilio L., Blatt, Michael R.

“…The dynamics of stomatal movements and their consequences for photosynthesis and transpirational water loss have long been incorporated into mathematical…”
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Quantitation of Malaria Parasite-Erythrocyte Cell-Cell Interactions Using Optical Tweezers by Crick, Alex J., Theron, Michel, Tiffert, Teresa, Lew, Virgilio L., Cicuta, Pietro, Rayner, Julian C.

“…Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and hence the pathogenesis of malaria. Invasion has been…”
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An Optimal Frequency in Ca²⁺ Oscillations for Stomatal Closure Is an Emergent Property of Ion Transport in Guard Cells by Minguet-Parramona, Carla, Wang, Yizhou, Hills, Adrian, Vialet-Chabrand, Silvere, Griffiths, Howard, Rogers, Simon, Lawson, Tracy, Lew, Virgilio L., Blatt, Michael R.

“…Oscillations in cytosolic-free Ca²⁺ concentration ([Ca²⁺]i) have been proposed to encode information that controls stomatal closure. [Ca²⁺]i oscillations with…”
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Evidence against a Role of Elevated Intracellular Ca2+ during Plasmodium falciparum Preinvasion by Introini, Viola, Crick, Alex, Tiffert, Teresa, Kotar, Jurij, Lin, Yen-Chun, Cicuta, Pietro, Lew, Virgilio L.

“…Severe malaria is primarily caused by Plasmodium falciparum parasites during their asexual reproduction cycle within red blood cells. One of the least…”
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Systems Dynamic Modeling of a Guard Cell Cl― Channel Mutant Uncovers an Emergent Homeostatic Network Regulating Stomatal Transpiration by YIZHOU WANG, PAPANATSIOU, Maria, EISENACH, Cornelia, KARNIK, Rucha, WILLIAMS, Mary, HILLS, Adrian, LEW, Virgilio L, BLATT, Michael R

“…Stomata account for much of the 70% of global water usage associated with agriculture and have a profound impact on the water and carbon cycles of the world…”
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Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells by Di Virgilio, A.L., Reigosa, M., Arnal, P.M., Fernández Lorenzo de Mele, M.

“…The aim of this study was to analyze the cytotoxicity and genotoxicity of titanium oxide (TiO 2) and aluminium oxide (Al 2O 3) nanoparticles (NPs) on Chinese…”
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Global Sensitivity Analysis of OnGuard Models Identifies Key Hubs for Transport Interaction in Stomatal Dynamics by Vialet-Chabrand, Silvere, Hills, Adrian, Wang, Yizhou, Griffiths, Howard, Lew, Virgilio L., Lawson, Tracy, Blatt, Michael R., Rogers, Simon

“…The physical requirement for charge to balance across biological membranes means that the transmembrane transport of each ionic species is interrelated, and…”
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Malaria: Surprising Mechanism of Merozoite Egress Revealed by Lew, Virgilio L.

“…A recent study reveals that the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum ends with the ruptured erythrocyte membrane curling…”
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Automated Live Imaging Platform for Studying Merozoite Egress-Invasion in Malaria Cultures by Crick, Alex J, Tiffert, Teresa, Shah, Sheel M, Kotar, Jurij, Lew, Virgilio L, Cicuta, Pietro

“…Most cases of severe and fatal malaria are caused by the intraerythrocytic asexual reproduction cycle of Plasmodium falciparum. One of the most intriguing and…”
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X-Ray Microanalysis Investigation of the Changes in Na, K, and Hemoglobin Concentration in Plasmodium falciparum-Infected Red Blood Cells by Mauritz, Jakob M.A., Seear, Rachel, Esposito, Alessandro, Kaminski, Clemens F., Skepper, Jeremy N., Warley, Alice, Lew, Virgilio L., Tiffert, Teresa

“…Plasmodium falciparum is responsible for severe malaria. During the ∼48 h duration of its asexual reproduction cycle in human red blood cells, the parasite…”
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