Search Results - "VIOLA, João P. B"

Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling by de Souza, Waldemir F, Fortunato-Miranda, Natalia, Robbs, Bruno K, de Araujo, Wallace M, de-Freitas-Junior, Julio C, Bastos, Lilian G, Viola, João P B, Morgado-Díaz, José A

“…The altered expressions of claudin proteins have been reported during the tumorigenesis of colorectal cancer. However, the molecular mechanisms that regulate…”
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NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death by Faget, Douglas V, Lucena, Pedro I, Robbs, Bruno K, Viola, João P B

“…The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes…”
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IRF2BP2: A new player in the regulation of cell homeostasis by Ramalho‐Oliveira, Renata, Oliveira‐Vieira, Barbara, Viola, João P.B.

“…The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF‐2) and is…”
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Lipid droplets: platforms with multiple functions in cancer hallmarks by Cruz, André L. S., Barreto, Ester de A., Fazolini, Narayana P. B., Viola, João P. B., Bozza, Patricia T.

“…Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism, membrane…”
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Dual Roles for NFAT Transcription Factor Genes as Oncogenes and Tumor Suppressors by Robbs, Bruno K., Cruz, Andre L. S., Werneck, Miriam B. F., Mognol, Giuliana P., Viola, João P. B.

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Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts by Teixeira, Lívia, Temerozo, Jairo R, Pereira-Dutra, Filipe S, Ferreira, André Costa, Mattos, Mayara, Gonçalves, Barbara Simonson, Sacramento, Carolina Q, Palhinha, Lohanna, Cunha-Fernandes, Tamires, Dias, Suelen S G, Soares, Vinicius Cardoso, Barreto, Ester A, Cesar-Silva, Daniella, Fintelman-Rodrigues, Natalia, Pão, Camila R R, de Freitas, Caroline S, Reis, Patrícia A, Hottz, Eugenio D, Bozza, Fernando A, Bou-Habib, Dumith C, Saraiva, Elvira M, de Almeida, Cecília J G, Viola, João P B, Souza, Thiago Moreno L, Bozza, Patricia T

“…Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational…”
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Evidence of recurrent selection of mutations commonly found in SARS-CoV-2 variants of concern in viruses infecting immunocompromised patients by Goes, Livia R., Siqueira, Juliana D., Garrido, Marianne M., Alves, Brunna M., Cicala, Claudia, Arthos, James, Viola, João P. B., Soares, Marcelo A.

“…Chronically immunosuppressed patients infected with SARS-CoV-2 often experience prolonged virus shedding, and may pave the way to the emergence of mutations…”
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Naso-oropharyngeal microbiome from breast cancer patients diagnosed with COVID-19 by Viana, Maria Carolina, Curty, Gislaine, Furtado, Carolina, Singh, Bhavya, Bendall, Matthew L, Viola, João P B, de Melo, Andreia Cristina, Soares, Marcelo A, Moreira, Miguel A M

“…Due to immunosuppressive cancer therapies, cancer patients diagnosed with COVID-19 have a higher chance of developing severe symptoms and present a higher…”
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The Transcriptional Co-factor IRF2BP2: A New Player in Tumor Development and Microenvironment by Pastor, Tatiane P, Peixoto, Barbara C, Viola, João P B

“…Interferon regulatory factor 2-binding protein 2 (IRF2BP2) encodes a member of the IRF2BP family of transcriptional regulators, which includes IRF2BP1,…”
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Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells by de Araújo-Souza, Patrícia S., Viola, João P. B., Hanschke, Steffi C. H.

“…Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only…”
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Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors by Neitzke-Montinelli, Vanessa, Calôba, Carolina, Melo, Guilherme, Frade, Bianca B, Caramez, Enzo, Mazzoccoli, Luciano, Gonçalves, André N A, Nakaya, Helder I, Pereira, Renata M, Werneck, Miriam B F, Viola, João P B

“…Long-term immunological protection relies on the differentiation and maintenance of memory lymphocytes. Since the knowledge of memory generation has been…”
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Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo by Chaves, Otávio Augusto, Sacramento, Carolina Q., Ferreira, André C., Mattos, Mayara, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R., Vazquez, Leonardo, Pinto, Douglas Pereira, da Silveira, Gabriel P. E., da Fonseca, Laís Bastos, Pereira, Heliana Martins, Carlos, Aluana Santana, d’Avila, Joana C., Viola, João P. B., Monteiro, Robson Q., Bozza, Patrícia T., Castro-Faria-Neto, Hugo Caire, Souza, Thiago Moreno L.

“…Atazanavir (ATV) has already been considered as a potential repurposing drug to 2019 coronavirus disease (COVID-19); however, there are controversial reports…”
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Osteopontin-c splicing isoform contributes to ovarian cancer progression by Tilli, Tatiana M, Franco, Vanessa Ferreira, Robbs, Bruno Kaufmann, Wanderley, João Luiz Mendes, da Silva, Fabrício Ribeiro de Azevedo, de Mello, Kivvi Duarte, Viola, João P B, Weber, Georg F, Gimba, Etel R

“…Ovarian carcinoma is one of the most aggressive gynecological diseases and generally diagnosed at advanced stages. Osteopontin (OPN) is one of the proteins…”
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Interferon Regulatory Factor 2 Binding Protein 2 Is a New NFAT1 Partner and Represses Its Transcriptional Activity by Carneiro, Flávia R. G., Ramalho-Oliveira, Renata, Mognol, Giuliana P., Viola, João P. B.

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Cutting Edge: Bradykinin Induces IL-12 Production by Dendritic Cells: A Danger Signal That Drives Th1 Polarization by Aliberti, Julio, Viola, Joao P. B, Vieira-de-Abreu, Adriana, Bozza, Patricia T, Sher, Alan, Scharfstein, Julio

“…Dendritic cells play a major role in the induction of both innate and acquired immune responses against pathogenic invaders. These cells are also able to sense…”
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Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation by Fazolini, Narayana P B, Cruz, André L S, Werneck, Miriam B F, Viola, João P B, Maya-Monteiro, Clarissa M, Bozza, Patrícia T

“…Accumulating evidence suggests that obesity and enhanced inflammatory reactions are predisposing conditions for developing colon cancer. Obesity is associated…”
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NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains by Lucena, Pedro I., Faget, Douglas V., Pachulec, Emilia, Robaina, Marcela C., Klumb, Claudete E., Robbs, Bruno K., Viola, João P. B.

“…The NFAT (nuclear factor of activated T cells) family of transcription factors is composed of four calcium-responsive proteins (NFAT1 to -4). The NFAT2 (also…”
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NFAT1 Regulates Ly6Chi Monocyte Recruitment to the CNS and Plays an Essential Role in Resistance to Toxoplasma gondii Infection by Benevides, Luciana, Saltarelli, Verônica M., Pioto, Franciele, Sacramento, Laís A., Dias, Murilo S., Rodríguez, Gretel R., Viola, João P. B., Carregaro, Vanessa, Silva, João S.

“…Monocytes play key roles in the maintenance of homeostasis and in the control of the infection. Monocytes are recruited from the bone marrow to inflammatory…”
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Lipid droplets in inflammation and cancer by Bozza, Patricia T, Viola, João P.B

“…Abstract Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes, epithelial cells, hepatocytes and other non-adipocytic…”
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NFAT1 transcription factor is central in the regulation of tissue microenvironment for tumor metastasis by Werneck, Miriam B. F., Vieira-de-Abreu, Adriana, Chammas, Roger, Viola, João P. B.

“…Members of the nuclear factor of activated T cell (NFAT) family of transcription factors were originally described in T lymphocytes but later shown to be…”
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