Search Results - "VINEGONI, Claudio"

Imaging the beating heart in the mouse using intravital microscopy techniques by Vinegoni, Claudio, Aguirre, Aaron D, Lee, Sungon, Weissleder, Ralph

“…This protocol enables microscopic imaging of organs in live mice by addressing tissue movement resulting from cardiac and respiratory cycles. Real-time…”
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Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration by Herisson, Fanny, Frodermann, Vanessa, Courties, Gabriel, Rohde, David, Sun, Yuan, Vandoorne, Katrien, Wojtkiewicz, Gregory R., Masson, Gustavo Santos, Vinegoni, Claudio, Kim, Jiwon, Kim, Dong-Eog, Weissleder, Ralph, Swirski, Filip K., Moskowitz, Michael A., Nahrendorf, Matthias

“…Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat…”
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Cardiac macrophages promote diastolic dysfunction by Hulsmans, Maarten, Sager, Hendrik B, Roh, Jason D, Valero-Muñoz, María, Houstis, Nicholas E, Iwamoto, Yoshiko, Sun, Yuan, Wilson, Richard M, Wojtkiewicz, Gregory, Tricot, Benoit, Osborne, Michael T, Hung, Judy, Vinegoni, Claudio, Naxerova, Kamila, Sosnovik, David E, Zile, Michael R, Bradshaw, Amy D, Liao, Ronglih, Tawakol, Ahmed, Weissleder, Ralph, Rosenzweig, Anthony, Swirski, Filip K, Sam, Flora, Nahrendorf, Matthias

“…Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in…”
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Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo by Razansky, Daniel, Ntziachristos, Vasilis, Distel, Martin, Vinegoni, Claudio, Ma, Rui, Perrimon, Norbert, Köster, Reinhard W

“…Fluorescent proteins have become essential reporter molecules for studying life at the cellular and sub-cellular level, re-defining the ways in which we…”
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The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells by Vasaturo, Michele, Cotugno, Roberta, Fiengo, Lorenzo, Vinegoni, Claudio, Dal Piaz, Fabrizio, De Tommasi, Nunziatina

“…The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular…”
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Multispectral photoacoustic imaging of fluorochromes in small animals by Razansky, Daniel, Vinegoni, Claudio, Ntziachristos, Vasilis

“…Fluorochromes have become essential reporter molecules in biological research. We show that the depth-resolved distribution of fluorochromes in small animals…”
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Real-time in vivo imaging of the beating mouse heart at microscopic resolution by Lee, Sungon, Vinegoni, Claudio, Feruglio, Paolo Fumene, Fexon, Lyuba, Gorbatov, Rostic, Pivoravov, Misha, Sbarbati, Andrea, Nahrendorf, Matthias, Weissleder, Ralph

“…Real-time imaging of moving organs and tissues at microscopic resolutions represents a major challenge in studying the complex biology of live animals. Here we…”
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Intravital imaging of cardiac function at the single-cell level by Aguirre, Aaron D., Vinegoni, Claudio, Sebas, Matt, Weissleder, Ralph

“…Knowledge of cardiomyocyte biology is limited by the lack of methods to interrogate single-cell physiology in vivo. Here we show that contracting myocytes can…”
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Automated motion artifact removal for intravital microscopy, without a priori information by Lee, Sungon, Vinegoni, Claudio, Sebas, Matthew, Weissleder, Ralph

“…Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular…”
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Hybrid PET-optical imaging using targeted probes by Nahrendorf, Matthias, Keliher, Edmund, Marinelli, Brett, Waterman, Peter, Feruglio, Paolo Fumene, Fexon, Lioubov, Pivovarov, Misha, Swirski, Filip K., Pittet, Mikael J., Vinegoni, Claudio, Weissleder, Ralph, Wilson, Brian

“…Fusion imaging of radionuclide-based molecular (PET) and structural data [x-ray computed tomography (CT)] has been firmly established. Here we show that…”
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PET/MRI of Inflammation in Myocardial Infarction by Lee, Won Woo, MD, PhD, Marinelli, Brett, BA, van der Laan, Anja M., MD, Sena, Brena F., BS, Gorbatov, Rostic, BS, Leuschner, Florian, MD, Dutta, Partha, PhD, Iwamoto, Yoshiko, BS, Ueno, Takuya, MD, PhD, Begieneman, Mark P.V., BS, Niessen, Hans W.M., MD, PhD, Piek, Jan J., MD, PhD, Vinegoni, Claudio, PhD, Pittet, Mikael J., PhD, Swirski, Filip K., PhD, Tawakol, Ahmed, MD, Di Carli, Marcelo, MD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD

“…Objectives The aim of this study was to explore post–myocardial infarction (MI) myocardial inflammation. Background Innate immune cells are centrally involved…”
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Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques by Vinegoni, Claudio, Botnaru, Ion, Aikawa, Elena, Calfon, Marcella A, Iwamoto, Yoshiko, Folco, Eduardo J, Ntziachristos, Vasilis, Weissleder, Ralph, Libby, Peter, Jaffer, Farouc A

“…New high-resolution molecular and structural imaging strategies are needed to visualize high-risk plaques that are likely to cause acute myocardial infarction,…”
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Imaging the Vascular Bone Marrow Niche During Inflammatory Stress by Vandoorne, Katrien, Rohde, David, Kim, Hye-Yeong, Courties, Gabriel, Wojtkiewicz, Gregory, Honold, Lisa, Hoyer, Friedrich Felix, Frodermann, Vanessa, Nayar, Ribhu, Herisson, Fanny, Jung, Yookyung, Désogère, Pauline A, Vinegoni, Claudio, Caravan, Peter, Weissleder, Ralph, Sosnovik, David E, Lin, Charles P, Swirski, Filip K, Nahrendorf, Matthias

“…RATIONALE:Inflammatory stress induced by exposure to bacterial lipopolysaccharide (LPS) causes hematopoietic stem cell (HSC) expansion in the bone marrow…”
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WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud by Gros, Jerome, Hu, Jimmy Kuang-Hsien, Vinegoni, Claudio, Feruglio, Paolo Fumene, Weissleder, Ralph, Tabin, Clifford J.

“…The vertebrate limb is a classical model for understanding patterning of three-dimensional structures during embryonic development. Although decades of…”
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Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response by Giedt, Randy J., Fumene Feruglio, Paolo, Pathania, Divya, Yang, Katherine S., Kilcoyne, Aoife, Vinegoni, Claudio, Mitchison, Timothy J., Weissleder, Ralph

“…Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on…”
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Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog by Reiner, Thomas, Thurber, Greg, Gaglia, Jason, Vinegoni, Claudio, Liew, Chong Wee, Upadhyay, Rabi, Kohler, Rainer H., Li, Li, Kulkarni, Rohit N., Benoist, Christophe, Mathis, Diane, Weissleder, Ralph

“…The hallmark of type 1 diabetes is autoimmune destruction of the insulin-producing β-cells of the pancreatic islets. Autoimmune diabetes has been difficult to…”
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Implantable microenvironments to attract hematopoietic stem/cancer cells by Lee, Jungwoo, Li, Matthew, Milwid, Jack, Dunham, Joshua, Vinegoni, Claudio, Gorbatov, Rostic, Iwamoto, Yoshiko, Wang, Fangjing, Shen, Keyue, Hatfield, Kimberley, Enger, Marianne, Shafiee, Sahba, McCormack, Emmet, Ebert, Benjamin L, Weissleder, Ralph, Yarmush, Martin L, Parekkadan, Biju

“…The environments that harbor hematopoietic stem and progenitor cells are critical to explore for a better understanding of hematopoiesis during health and…”
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Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis by JAFFER, Farouc A, VINEGONI, Claudio, JOHN, Michael C, AIKAWA, Elena, GOLD, Herman K, FINN, Aloke V, NTZIACHRISTOS, Vasilis, LIBBY, Peter, WEISSLEDER, Ralph

“…To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense…”
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Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging by Roy, Jeremy, Kim, Bongki, Hill, Eric, Visconti, Pablo, Krapf, Dario, Vinegoni, Claudio, Weissleder, Ralph, Brown, Dennis, Breton, Sylvie

“…Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long…”
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Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents by Reiner, Thomas, Lacy, Jessica, Keliher, Edmund J, Yang, Katherine S, Ullal, Adeeti, Kohler, Rainer H, Vinegoni, Claudio, Weissleder, Ralph

“…A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and…”
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