Search Results - "VINALS, Francesc"

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability by Méndez-Lucas, Andrés, Hyroššová, Petra, Novellasdemunt, Laura, Viñals, Francesc, Perales, Jose C.

“…Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), encoded by the nuclear PCK2 gene, links TCA cycle intermediates and glycolytic pools through the…”
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SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells by Medina‐Jover, Ferran, Gendrau‐Sanclemente, Núria, Viñals, Francesc

“…BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor…”
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The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels by Alsina‐Sanchis, Elisenda, Figueras, Agnès, Lahiguera, Álvaro, Vidal, August, Casanovas, Oriol, Graupera, Mariona, Villanueva, Alberto, Viñals, Francesc

“…In a search for new therapeutic targets for treating epithelial ovarian cancer, we analyzed the Transforming Growth Factor Beta (TGFβ) signaling pathway in…”
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Metronomic chemotherapy following the maximum tolerated dose is an effective anti‐tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells by Vives, Marta, Ginestà, Mireia M., Gracova, Kristina, Graupera, Mariona, Casanovas, Oriol, Capellà, Gabriel, Serrano, Teresa, Laquente, Berta, Viñals, Francesc

“…In this article, the effectiveness of a multi‐targeted chemo‐switch (C‐S) schedule that combines metronomic chemotherapy (MET) after treatment with the maximum…”
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Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors by Soler, Adriana, Figueiredo, Ana M, Castel, Pau, Martin, Laura, Monelli, Erika, Angulo-Urarte, Ana, Milà-Guasch, Maria, Viñals, Francesc, Baselga, Jose, Casanovas, Oriol, Graupera, Mariona

“…Mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an exciting…”
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis by Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S, Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart

“…Understanding the direct, tumor cell-intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer…”
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New genetic drivers in hemorrhagic hereditary telangiectasia by Cerdà, Pau, Castillo, Sandra D, Aguilera, Cinthia, Iriarte, Adriana, Rocamora, José Luis, Larrinaga, Ane M, Viñals, Francesc, Graupera, Mariona, Riera-Mestre, Antoni

“…Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disease inherited in an autosomal dominant manner. Disease-causing variants in endoglin (ENG)…”
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A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination by Figueras, Agnès, Alsina-Sanchís, Elisenda, Lahiguera, Álvaro, Abreu, Manuel, Muinelo-Romay, Laura, Moreno-Bueno, Gema, Casanovas, Oriol, Graupera, Mariona, Matias-Guiu, Xavier, Vidal, August, Villanueva, Alberto, Viñals, Francesc

“…Epithelial ovarian cancer is characterized by a low recovery rate because the disease is typically diagnosed at an advanced stage, by which time most patients…”
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Filamin B Plays a Key Role in Vascular Endothelial Growth Factor-induced Endothelial Cell Motility through Its Interaction with Rac-1 and Vav-2 by del Valle-Pérez, Beatriz, Martínez, Vanesa Gabriela, Lacasa-Salavert, Cristina, Figueras, Agnès, Shapiro, Sandor S., Takafuta, Toshiro, Casanovas, Oriol, Capellà, Gabriel, Ventura, Francesc, Viñals, Francesc

“…Actin-binding proteins filamin A (FLNA) and B (FLNB) are expressed in endothelial cells and play an essential role during vascular development. In order to…”
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Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway by Gómez, Marta, Manzano, Anna, Figueras, Agnes, Viñals, Francesc, Ventura, Francesc, Rosa, Jose Luis, Bartrons, Ramon, Navarro-Sabaté, Àurea

“…Sertoli cells play a central role in the control and maintenance of spermatogenesis by secreting growth factors, in response to hormonal stimulation, that…”
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The impact of KRAS mutations on VEGF-A production and tumour vascular network by Figueras, Agnès, Arbos, Maria Antonia, Quiles, Maria Teresa, Viñals, Francesc, Germà, Josep Ramón, Capellà, Gabriel

“…The malignant potential of tumour cells may be influenced by the molecular nature of KRAS mutations being codon 13 mutations less aggressive than codon 12…”
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The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer by Martínez-Bosch, Neus, Guerrero, Pedro Enrique, Moreno, Mireia, José, Anabel, Iglesias, Mar, Munné-Collado, Jessica, Anta, Héctor, Gibert, Joan, Orozco, Carlos Alberto, Vinaixa, Judith, Fillat, Cristina, Viñals, Francesc, Navarro, Pilar

“…Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a…”
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Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis by Pàez-Ribes, Marta, Allen, Elizabeth, Hudock, James, Takeda, Takaaki, Okuyama, Hiroaki, Viñals, Francesc, Inoue, Masahiro, Bergers, Gabriele, Hanahan, Douglas, Casanovas, Oriol

“…Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that…”
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BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells by Susperregui, Antonio R.G., Viñals, Francesc, Ho, Patricia W.M., Gillespie, Matthew T., Martin, T. John, Ventura, Francesc

“…Bone morphogenetic protein‐2 (BMP‐2) is strongly involved in the induction of osteoblast differentiation from mesenchymal cell precursors, as well as in…”
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Myogenin Protein Stability Is Decreased by BMP-2 through a Mechanism Implicating Id1 by Viñals Canals, Francesc, Ventura Pujol, Francesc

“…Bone morphogenetic protein-2 (BMP-2) induces a switch in differentiation of mesenchymal cells from the myogenic to the osteogenic lineage. Here we describe…”
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Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility by Angulo-Urarte, Ana, Casado, Pedro, Castillo, Sandra D., Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana M., Castel, Pau, Rajeeve, Vinothini, Milà-Guasch, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laia, Casanovas, Oriol, Viñals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R., Graupera, Mariona

“…Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are…”
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Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients by Jiménez-Valerio, Gabriela, Martínez-Lozano, Mar, Bassani, Nicklas, Vidal, August, Ochoa-de-Olza, María, Suárez, Cristina, García-del-Muro, Xavier, Carles, Joan, Viñals, Francesc, Graupera, Mariona, Indraccolo, Stefano, Casanovas, Oriol

“…Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily…”
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ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation by Alsina-Sanchís, Elisenda, García-Ibáñez, Yaiza, Figueiredo, Ana M, Riera-Domingo, Carla, Figueras, Agnès, Matias-Guiu, Xavier, Casanovas, Oriol, Botella, Luisa M, Pujana, Miquel A, Riera-Mestre, Antoni, Graupera, Mariona, Viñals, Francesc

“…OBJECTIVE—ALK1 (activin-receptor like kinase 1) is an endothelial cell-restricted receptor with high affinity for BMP (bone morphogenetic protein) 9 TGF-β…”
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PTEN mediates Notch-dependent stalk cell arrest in angiogenesis by Serra, Helena, Chivite, Iñigo, Angulo-Urarte, Ana, Soler, Adriana, Sutherland, James D., Arruabarrena-Aristorena, Amaia, Ragab, Anan, Lim, Radiance, Malumbres, Marcos, Fruttiger, Marcus, Potente, Michael, Serrano, Manuel, Fabra, Àngels, Viñals, Francesc, Casanovas, Oriol, Pandolfi, Pier Paolo, Bigas, Anna, Carracedo, Arkaitz, Gerhardt, Holger, Graupera, Mariona

“…Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in…”
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RANK Induces Epithelial―Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis by PALAFOX, Marta, FERRER, Irene, TOMETSKO, Mark, BRANSTETTER, Dan, DOUGALL, William C, GONZALEZ-SUAREZ, Eva, PELLEGRINI, Pasquale, VILA, Sergi, HERNANDEZ-ORTEGA, Sara, URRUTICOECHEA, Ander, CLIMEN, Fina, SOLER, Maria Teresa, MUNOZ, Purificación, VINALS, Francesc

“…Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation…”
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