Search Results - "VINA, Jose"

The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging by Viña, Jose

“…The free radical theory of ageing has provided a framework of research into ageing based on Harman's idea that ageing was caused by damage produced by free…”
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Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine by Mas-Bargues, Cristina, Sanz-Ros, Jorge, Román-Domínguez, Aurora, Inglés, Marta, Gimeno-Mallench, Lucia, El Alami, Marya, Viña-Almunia, José, Gambini, Juan, Viña, José, Borrás, Consuelo

“…The key hallmark of stem cells is their ability to self-renew while keeping a differentiation potential. Intrinsic and extrinsic cell factors may contribute to…”
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Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide by Viña, Jose, Lloret, Ana

“…The main risk factors for developing Alzheimer's disease (AD) are age and gender. The incidence of the disease is higher in women than in men, and this cannot…”
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Physical exercise in the prevention and treatment of Alzheimer's disease by De la Rosa, Adrian, Olaso-Gonzalez, Gloria, Arc-Chagnaud, Coralie, Millan, Fernando, Salvador-Pascual, Andrea, García-Lucerga, Consolacion, Blasco-Lafarga, Cristina, Garcia-Dominguez, Esther, Carretero, Aitor, Correas, Angela G., Viña, Jose, Gomez-Cabrera, Mari Carmen

“…•Low levels of physical activity are a risk factor associated with Alzheimer's disease.•Older adults who exercise are more likely to maintain…”
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Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan by Viña, Jose, Borrás, Consuelo

“…In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. This review examines the link between mitochondrial…”
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A free radical theory of frailty by Viña, Jose, Borras, Consuelo, Gomez-Cabrera, Mari Carmen

“…The free radical theory of ageing provided an intellectual framework for many laboratories working on ageing. However, experimental and clinical evidence…”
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Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training by Gomez-Cabrera, Mari-Carmen, Domenech, Elena, Viña, Jose

“…Exercise causes oxidative stress only when exhaustive. Strenuous exercise causes oxidation of glutathione, release of cytosolic enzymes, and other signs of…”
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Redox lipidomics to better understand brain aging and function by Pamplona, Reinald, Borras, Consuelo, Jové, Mariona, Pradas, Irene, Ferrer, Isidre, Viña, Jose

“…Human prefrontal cortex (PFC) is a recently evolutionary emerged brain region involved in cognitive functions. Human cognitive abilities decline during aging…”
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Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project by Rodríguez-Mañas, Leocadio, Féart, Catherine, Mann, Giovanni, Viña, Jose, Chatterji, Somnath, Chodzko-Zajko, Wojtek, Gonzalez-Colaço Harmand, Magali, Bergman, Howard, Carcaillon, Laure, Nicholson, Caroline, Scuteri, Angelo, Sinclair, Alan, Pelaez, Martha, Van der Cammen, Tischa, Beland, François, Bickenbach, Jerome, Delamarche, Paul, Ferrucci, Luigi, Fried, Linda P, Gutiérrez-Robledo, Luis Miguel, Rockwood, Kenneth, Rodríguez Artalejo, Fernando, Serviddio, Gaetano, Vega, Enrique

“…There is no consensus regarding the definition of frailty for clinical uses. A modified Delphi process was used to attempt to achieve consensus definition…”
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Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress by Borrás, Consuelo, Abdelaziz, Kheira M., Mas-Bargues, C., Monleón, Daniel, Gambini, Juan, Lopez-Grueso, R., Díaz, Ana, Viña, Jose

“…Females live longer than males, and the estrogens are one of the reasons for this difference. We reported some years ago that estrogens are able to protect…”
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Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance by Gomez-Cabrera, Mari-Carmen, Domenech, Elena, Romagnoli, Marco, Arduini, Alessandro, Borras, Consuelo, Pallardo, Federico V, Sastre, Juan, Viña, Jose

“…Exercise practitioners often take vitamin C supplements because intense muscular contractile activity can result in oxidative stress, as indicated by altered…”
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Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging by Olivieri, Fabiola, Capri, Miriam, Bonafè, Massimiliano, Morsiani, Cristina, Jung, Hwa Jin, Spazzafumo, Liana, Viña, Jose, Suh, Yousin

“…•Trajectories of healthy aging can be traced in cross-sectional/longitudinal cohorts by having centenarians and centenarians’ offspring among last age-…”
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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome by Abraham, Dora, Feher, Janos, Scuderi, Gian Luca, Szabo, Dora, Dobolyi, Arpad, Cservenak, Melinda, Juhasz, Janos, Ligeti, Balazs, Pongor, Sandor, Gomez-Cabrera, Mari Carmen, Vina, Jose, Higuchi, Mitsuru, Suzuki, Katsuhiro, Boldogh, Istvan, Radak, Zsolt

“…It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1…”
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Methionine transsulfuration pathway is upregulated in long-lived humans by Mota-Martorell, Natàlia, Jové, Mariona, Borrás, Consuelo, Berdún, Rebeca, Obis, Èlia, Sol, Joaquim, Cabré, Rosanna, Pradas, Irene, Galo-Licona, José Daniel, Puig, Josep, Viña, José, Pamplona, Reinald

“…Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma…”
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Extracellular vesicles and redox modulation in aging by Borras, Consuelo, Mas-Bargues, Cristina, Sanz-Ros, Jorge, Román-Domínguez, Aurora, Gimeno-Mallench, Lucia, Inglés, Marta, Gambini, Juan, Viña, Jose

“…Extracellular vesicles (EVs) are nowadays known to be mediators of cell-to-cell communication involved in physiological and pathological processes. The current…”
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Direct antioxidant and protective effect of estradiol on isolated mitochondria by Borrás, Consuelo, Gambini, Juan, López-Grueso, Raúl, Pallardó, Federico V., Viña, Jose

“…Estrogens have antioxidant properties which are due to their ability to bind to estrogen receptors and to up-regulate the expression of antioxidant enzymes via…”
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Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases by Derbre, Frederic, Ferrando, Beatriz, Gomez-Cabrera, Mari Carmen, Sanchis-Gomar, Fabian, Martinez-Bello, Vladimir E, Olaso-Gonzalez, Gloria, Diaz, Ana, Gratas-Delamarche, Arlette, Cerda, Miguel, Viña, Jose

“…Alterations in muscle play an important role in common diseases and conditions. Reactive oxygen species (ROS) are generated during hindlimb unloading due, at…”
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Even free radicals should follow some rules: A Guide to free radical research terminology and methodology by Forman, Henry Jay, Augusto, Ohara, Brigelius-Flohe, Regina, Dennery, Phyllis A., Kalyanaraman, Balaraman, Ischiropoulos, Harry, Mann, Giovanni E., Radi, Rafael, Roberts, L. Jackson, Vina, Jose, Davies, Kelvin J.A.

“…Free radicals and oxidants are now implicated in physiological responses and in several diseases. Given the wide range of expertise of free radical…”
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Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study by Nepomuceno, Mariana, Monllor, Paloma, Cardells, Maria Jose, Ftara, Artemis, Magallon, Maria, Dasí, Francisco, Badia, Mari Carmen, Viña, Jose, Lloret, Ana

“…Carrying an allele 4 of the apolipoprotein E (ApoE) is the best-established genetic risk factor to develop Alzheimer's disease (AD). Fifty percent of ApoE4/4…”
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Redox-related biomarkers in physical exercise by Gomez-Cabrera, Mari Carmen, Carretero, Aitor, Millan-Domingo, Fernando, Garcia-Dominguez, Esther, Correas, Angela G, Olaso-Gonzalez, Gloria, Viña, Jose

“…Research in redox biology of exercise has made considerable advances in the last 70 years. Since the seminal study of George Pake's group calculating the…”
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