Search Results - "VILLANUEVA, Flordeliza S"

A multicellular brain spheroid model for studying the mechanisms and bioeffects of ultrasound-enhanced drug penetration beyond the blood‒brain barrier by Paranjape, Anurag N., D’Aiuto, Leonardo, Zheng, Wenxiao, Chen, Xucai, Villanueva, Flordeliza S.

“…The blood‒brain barrier (BBB) acts as a hindrance to drug therapy reaching the brain. With an increasing incidence of neurovascular diseases and brain cancer…”
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Ultrasound-Targeted Microbubble Destruction to Deliver siRNA Cancer Therapy by CARSON, Andrew R, MCTIERNAN, Charles F, LAVERY, Linda, GRATA, Michelle, XIAOPING LENG, JIANJUN WANG, XUCAI CHEN, VILLANUEVA, Flordeliza S

“…Microbubble contrast agents can specifically deliver nucleic acids to target tissues when exposed to ultrasound treatment parameters that mediate microbubble…”
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STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors by Ramasamy, Thiruganesh, Chen, Xucai, Qin, Bin, Johnson, Daniel E, Grandis, Jennifer R, Villanueva, Flordeliza S

“…Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug…”
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Low Intensity Ultrasound Mediated Liposomal Doxorubicin Delivery Using Polymer Microbubbles by Yu, Francois T. H, Chen, Xucai, Wang, Jianjun, Qin, Bin, Villanueva, Flordeliza S

“…Cardiotoxicity is the major dose-limiting factor in the chemotherapeutic use of doxorubicin (Dox). A delivery vehicle that can be triggered to release its…”
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Cardiac Gene Expression Knockdown Using Small Inhibitory RNA-Loaded Microbubbles and Ultrasound by Kopechek, Jonathan A, Carson, Andrew R, McTiernan, Charles F, Chen, Xucai, Klein, Edwin C, Villanueva, Flordeliza S

“…RNA interference has potential therapeutic value for cardiac disease, but targeted delivery of interfering RNA is a challenge. Custom designed microbubbles, in…”
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Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice by Gbotosho, Oluwabukola T, Kapetanaki, Maria G, Ghosh, Samit, Villanueva, Flordeliza S, Ofori-Acquah, Solomon F, Kato, Gregory J

“…Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme,…”
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Individual lipid encapsulated microbubble radial oscillations: Effects of fluid viscosity by Helfield, Brandon, Chen, Xucai, Qin, Bin, Villanueva, Flordeliza S

“…Ultrasound-stimulated microbubble dynamics have been shown to be dependent on intrinsic bubble properties, including size and shell characteristics. The effect…”
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Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification by Kooiman, Klazina, van Rooij, Tom, Qin, Bin, Mastik, Frits, Vos, Hendrik J, Versluis, Michel, Klibanov, Alexander L, de Jong, Nico, Villanueva, Flordeliza S, Chen, Xucai

“…Acoustic behavior of lipid-coated microbubbles has been widely studied, which has led to several numerical microbubble dynamics models that incorporate lipid…”
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Gene Therapy of Carcinoma Using Ultrasound-Targeted Microbubble Destruction by Carson, Andrew R, McTiernan, Charles F, Lavery, Linda, Hodnick, Abigail, Grata, Michelle, Leng, Xiaoping, Wang, Jianjun, Chen, Xucai, Modzelewski, Ruth A, Villanueva, Flordeliza S

“…Abstract When microbubble contrast agents are loaded with genes and systemically injected, ultrasound-targeted microbubble destruction (UTMD) facilitates…”
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Biophysical insight into mechanisms of sonoporation by Helfield, Brandon, Chen, Xucai, Watkins, Simon C., Villanueva, Flordeliza S.

“…This study presents a unique approach to understanding the biophysical mechanisms of ultrasound-triggered cell membrane disruption (i.e., sonoporation). We…”
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Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine by WELLER, Gregory E. R, WONG, Michael K. K, MODZELEWSKI, Ruth A, ERXIONG LU, KLIBANOV, Alexander L, WAGNER, William R, VILLANUEVA, Flordeliza S

“…Endothelial cells (EC) of angiogenic tumor vasculature are characterized by altered expression of molecular markers on their surface. Numerous peptides have…”
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New insights into the microvascular mechanisms of drag reducing polymers: effect on the cell-free layer by Brands, Judith, Kliner, Dustin, Lipowsky, Herbert H, Kameneva, Marina V, Villanueva, Flordeliza S, Pacella, John J

“…Drag-reducing polymers (DRPs) significantly increase blood flow, tissue perfusion, and tissue oxygenation in various animal models. In rectangular channel…”
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Noninvasive Detection of Lipids in Atherosclerotic Plaque Using Ultrasound Thermal Strain Imaging by Mahmoud, Ahmed M., PhD, Dutta, Debaditya, PhD, Lavery, Linda, BS, Stephens, Douglas N., MS, Villanueva, Flordeliza S., MD, Kim, Kang, PhD

“…Objectives This study sought to examine the feasibility of in vivo detection of lipids in atherosclerotic plaque (AP) by ultrasound (US) thermal (or temporal)…”
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Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application by Leng, Xiaoping, Wang, Jianjun, Carson, Andrew, Chen, Xucai, Fu, Huili, Ottoboni, Susanne, Wagner, William R., Villanueva, Flordeliza S.

“…Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus “ischemic…”
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Detection of elevated right atrial pressure using a simple bedside ultrasound measure by Simon, Marc A., MS, MD, FACC, Kliner, Dustin E., MD, Girod, John P., DO, Moguillansky, Diego, MD, Villanueva, Flordeliza S., MD, FACC, Pacella, John J., MS, MD, FACC

“…Aims Accurate assessment of right atrial pressure (RAP) often requires invasive measurement. With normal RAP, Valsalva increases right internal jugular vein…”
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In vivo PEG modification of vascular surfaces for targeted delivery by Deglau, Timothy E., PhD, Maul, Timothy M., PhD, Villanueva, Flordeliza S., MD, Wagner, William R., PhD

“…Objective Thrombosis and restenosis remain problematic for many intravascular procedures. Previously, it has been demonstrated that modifying an injured…”
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Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation by Helfield, Brandon, Chen, Xucai, Watkins, Simon C., Villanueva, Flordeliza S.

“…Acoustically driven gas bubble cavitation locally concentrates energy and can result in physical phenomena including sonoluminescence and erosion. In…”
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Association of Hypertensive Disorders of Pregnancy With Left Ventricular Remodeling Later in Life by Countouris, Malamo E, Villanueva, Flordeliza S, Berlacher, Kathryn L, Cavalcante, João L, Parks, W Tony, Catov, Janet M

“…Hypertensive disorders of pregnancy (HDP) are associated with short-term cardiac structure and function abnormalities, but later life changes are not well…”
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Development of an In Vitro Model to Study Mechanisms of Ultrasound-Targeted Microbubble Cavitation–Mediated Blood–Brain Barrier Opening by Conway, Grace E., Paranjape, Anurag N., Chen, Xucai, Villanueva, Flordeliza S.

“…Ultrasound-targeted microbubble cavitation (UTMC)-mediated blood–brain barrier (BBB) opening is being explored as a method to increase drug delivery to the…”
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Ultrasound-Induced Microbubble Cavitation for Targeted Delivery of MiR-29b Mimic to Treat Cardiac Fibrosis by Feroze, Rafey A., Kopechek, Jonathan, Zhu, Jianhui, Chen, Xucai, Villanueva, Flordeliza S.

“…OBJECTIVECardiac fibrosis contributes to adverse ventricular remodeling and is associated with loss of miR-29b. Overexpression of miR-29b via plasmid or…”
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