Search Results - "VILLALTA, S"

Regulatory interactions between muscle and the immune system during muscle regeneration by Tidball, James G, Villalta, S Armando

“…Recent discoveries reveal complex interactions between skeletal muscle and the immune system that regulate muscle regeneration. In this review, we evaluate…”
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Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype by ARMANDO VILLALTA, S, RINALDI, Chiara, BO DENG, LIU, Grace, FEDOR, Brian, TIDBALL, James G

“…M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne muscular dystrophy. However, mdx muscle also contains M2c…”
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Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy by Villalta, S. Armando, Nguyen, Hal X., Deng, Bo, Gotoh, Tomomi, Tidball, James G.

“…Duchenne muscular dystrophy (DMD) is the most common, lethal, muscle-wasting disease of childhood. Previous investigations have shown that muscle macrophages…”
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Muscle immune cells alleviate exercise woes by Coulis, Gerald, Villalta, S Armando

“…An alternative interpretation is that Treg cells lacking CD25 are functional, but deficits in muscle adaptation to exercise as a result of CD25-specific…”
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Muscle immune cells protect mitochondrial organelles during exercise by Coulis, Gerald, Villalta, S. Armando

“…A suppressive type of immune cell called a regulatory T cell has a key role in helping muscles to adapt to exercise — guarding muscle mitochondrial organelles…”
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IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration by Deng, Bo, Wehling-Henricks, Michelle, Villalta, S Armando, Wang, Ying, Tidball, James G

“…We examined the function of IL-10 in regulating changes in macrophage phenotype during muscle growth and regeneration following injury. Our findings showed…”
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Immune-mediated pathology in Duchenne muscular dystrophy by Rosenberg, Amy S, Puig, Montserrat, Nagaraju, Kanneboyina, Hoffman, Eric P, Villalta, S Armando, Rao, V Ashutosh, Wakefield, Lalage M, Woodcock, Janet

“…Immunological and inflammatory processes downstream of dystrophin deficiency as well as metabolic abnormalities, defective autophagy, and loss of regenerative…”
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FOXO1 Mediates Vitamin D Deficiency–Induced Insulin Resistance in Skeletal Muscle by Chen, Songcang, Villalta, S Armando, Agrawal, Devendra K

“…ABSTRACT Prospective epidemiological studies have consistently shown a relationship between vitamin D deficiency, insulin resistance, and type 2 diabetes…”
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Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy by Villalta, S Armando, Rosenthal, Wendy, Martinez, Leonel, Kaur, Amanjot, Sparwasser, Tim, Tidball, James G, Margeta, Marta, Spencer, Melissa J, Bluestone, Jeffrey A

“…We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD)…”
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Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation by Dragan, Morgan, Sun, Peng, Chen, Zeyu, Ma, Xianghui, Vu, Remy, Shi, Yuling, Villalta, S. Armando, Dai, Xing

“…Skin epidermis constitutes the exterior barrier that protects the body from dehydration and environmental assaults. Barrier defects underlie common…”
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Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes by Morita, Shuhei, Villalta, S Armando, Feldman, Hannah C, Register, Ames C, Rosenthal, Wendy, Hoffmann-Petersen, Ingeborg T, Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, Colon-Negron, Kevin, Meza-Acevedo, Rosa, Backes, Bradley J, Maly, Dustin J, Bluestone, Jeffrey A, Papa, Feroz R

“…In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades…”
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IFN-γ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation by Villalta, S Armando, Deng, Bo, Rinaldi, Chiara, Wehling-Henricks, Michelle, Tidball, James G

“…Duchenne muscular dystrophy is a degenerative disorder that leads to death by the third decade of life. Previous investigations have shown that macrophages…”
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Immunophenotyping of Inclusion Body Myositis Blood T and NK Cells by Goyal, Namita A., Coulis, Gérald, Duarte, Jorge, Farahat, Philip K., Mannaa, Ali H., Cauchii, Jonathan, Irani, Tyler, Araujo, Nadia, Wang, Leo, Wencel, Marie, Li, Vivian, Zhang, Lishi, Greenberg, Steven A., Mozaffar, Tahseen, Villalta, S. Armando

“…To evaluate the therapeutic potential of targeting highly differentiated T cells in patients with inclusion body myositis (IBM) by establishing high-resolution…”
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NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice by Fotio, Yannick, Mabou Tagne, Alex, Squire, Erica, Lee, Hye-lim, Phillips, Connor M., Chang, Kayla, Ahmed, Faizy, Greenberg, Andrew S., Villalta, S. Armando, Scarfone, Vanessa M., Spadoni, Gilberto, Mor, Marco, Piomelli, Daniele

“…Circulating monocytes participate in pain chronification but the molecular events that cause their deployment are unclear. Using a mouse model of hyperalgesic…”
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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis by Evans, Katrina T., Blake, Kerrigan, Longworth, Aaron, Coburn, Morgan A., Insua-Rodríguez, Jacob, McMullen, Timothy P., Nguyen, Quy H., Ma, Dennis, Lev, Tatyana, Hernandez, Grace A., Oganyan, Armani K., Orujyan, Davit, Edwards, Robert A., Pridans, Clare, Green, Kim N., Villalta, S. Armando, Blurton-Jones, Mathew, Lawson, Devon A.

“…Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior work has shown that brain cancers and metastases are densely…”
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Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis by Britson, Kyla A, Ling, Jonathan P, Braunstein, Kerstin E, Montagne, Janelle M, Kastenschmidt, Jenna M, Wilson, Andrew, Ikenaga, Chiseko, Tsao, William, Pinal-Fernandez, Iago, Russell, Katelyn A, Reed, Nicole, Mozaffar, Tahseen, Wagner, Kathryn R, Ostrow, Lyle W, Corse, Andrea M, Mammen, Andrew L, Villalta, S Armando, Larman, H Benjamin, Wong, Philip C, Lloyd, Thomas E

“…Sporadic inclusion body myositis (IBM) is the most common acquired muscle disease in adults over age 50, yet it remains unclear whether the disease is…”
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A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression by Kastenschmidt, Jenna M., Coulis, Gerald, Farahat, Philip K., Pham, Phillip, Rios, Rodolfo, Cristal, Therese T., Mannaa, Ali H., Ayer, Rachel E., Yahia, Rayan, Deshpande, Archis A., Hughes, Brandon S., Savage, Adam K., Giesige, Carlee R., Harper, Scott Q., Locksley, Richard M., Mozaffar, Tahseen, Villalta, S. Armando

“…Despite the well-accepted view that chronic inflammation contributes to the pathogenesis of Duchenne muscular dystrophy (DMD), the function and regulation of…”
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A cellular and molecular spatial atlas of dystrophic muscle by Stec, Michael J, Su, Qi, Adler, Christina, Zhang, Lance, Golann, David R, Khan, Naveen P, Panagis, Lampros, Villalta, S Armando, Ni, Min, Wei, Yi, Walls, Johnathon R, Murphy, Andrew J, Yancopoulos, George D, Atwal, Gurinder S, Kleiner, Sandra, Halasz, Gabor, Sleeman, Mark W

“…Asynchronous skeletal muscle degeneration/regeneration is a hallmark feature of Duchenne muscular dystrophy (DMD); however, traditional -omics technologies…”
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Mast Cell IL-6 Improves Survival from Klebsiella Pneumonia and Sepsis by Enhancing Neutrophil Killing by Sutherland, Rachel E, Olsen, Joanna S, McKinstry, Andrew, Villalta, S. Armando, Wolters, Paul J

“…The pleiotropic cytokine IL-6 has favorable and harmful effects on survival from bacterial infections. Although many innate immune cells produce IL-6, little…”
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Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation by Mohammadi, M. Rezaa, Rodriguez, Samuel Mathew, Luong, Jennifer Cam, Li, Shiri, Cao, Rui, Alshetaiwi, Hamad, Lau, Hien, Davtyan, Hayk, Jones, Mathew Blurton, Jafari, Mahtab, Kessenbrock, Kai, Villalta, S. Armando, de Vos, Paul, Zhao, Weian, Lakey, Jonathan R. T.

“…Foreign body response (FBR) to biomaterials compromises the function of implants and leads to medical complications. Here, we report a hybrid alginate…”
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